Membrane bioreactor used in microgravity environment and simulated microgravity environment

Abstract

The invention relates to a membrane bioreactor device for the efficient culture of suspended biological cells and in particular relates to a membrane bioreactor used in the microgravity environment and the simulated microgravity environment. The membrane bioreactor is mainly used in the microgravity environment and used as a ground simulated microgravity experimental device to perform the long-term culture of suspended biological cells and the biological effect research and the efficient preparation method research of recombinant protein. The membrane bioreactor comprises a bioreactor main body, an air supply system, a liquid filling system, a stirring system, a parameter measurement and control system, an exhaust system and a sampling system, wherein the parameter measurement and controlsystem comprises a pH value parameter measurement and control system, a temperature parameter measurement and control system, a dissolved oxygen parameter measurement and control system and a pressure parameter measurement and control system. The membrane bioreactor device can be utilized to realize the long-term and efficient culture of suspended biological cells in the microgravity environment and the ground simulated microgravity environment, the multi-parameter real-time detection and the automatic control.

Description

technical field [0001] The invention relates to a membrane bioreactor device for efficiently cultivating suspended biological cells, in particular to a membrane bioreactor used in microgravity and simulated microgravity environments, mainly used in microgravity environments and as ground simulated microgravity experiments The device is used for long-term culture of suspended biological cells and research on biological effects, as well as research on the efficient preparation of recombinant proteins. Background technique [0002] In the space microgravity environment, the convection phenomenon in the gas and liquid disappears, the buoyancy disappears, the component separation and sinking phenomenon caused by different densities disappear, the static pressure of the fluid disappears, and so on. This makes it difficult to separate the three phases of gas, liquid and solid, and increases the difficulty in the supply of oxygen, the discharge of waste gas, and the uniform mass tra...

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the technical problem that the biological cell culture device in the microgravity environment cannot satisfy the long-term and high-efficiency culture research of suspended biological cells, and provide a simple structure, high culture efficiency, and real-time detection of multi-parameters of the culture system. And automatic regulation, it can be used in microgravity and ground simulated microgravity environment for long-term high-efficiency cultivation of suspended biological cells, multi-parameter real-time detection and automatic regulation of multifunctional membrane bioreactors

Images