In-situ formed acyclovir spraying agent and preparation method thereof

An in-situ forming and spraying technology, which is applied in the direction of medical preparations of non-active ingredients, aerosol delivery, antiviral agents, etc., to achieve the effect of increasing the treatment of applicable diseases, adjusting the dosage, and prolonging the retention

Active Publication Date: 2011-10-05
ZHEJIANG ZHEBEI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Chinese invention patent application (Application No.: 200810116084.X) discloses acyclovir ophthalmic pH-sensitive in-situ gel and its preparation method, but its in-situ gel-forming mechanism is pH-sensitive, which is only applicable to the eyes special environment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation Process:

[0029] Weigh 20g of poloxamer 407 and dissolve in an appropriate amount of water; weigh 3g of acyclovir and dissolve in an appropriate amount of 0.1N NaOH solution; mix the two parts evenly, stir well, add 20g of glycerin, and add water to 100ml.

[0030] Product properties:

[0031] The appearance of the obtained spray solution is clear, and the content measurement result shows that the acyclovir content is 3%. After bottling, each spray solution is 0.2ml, and the total number of sprays is about 80 times. Rabbits were used for skin irritation test and the result was non-irritating. It takes 20s for the spray liquid to form a drug film on the rabbit skin, and there is no loss of the drug solution.

Embodiment 2

[0033] Preparation Process:

[0034] Weigh 10g of chitosan, dissolve in an appropriate amount of water phase, add 16g of glycerin; weigh 2 g of acyclovir, dissolve in an appropriate amount of 0.1N NaOH solution; mix the two parts evenly, stir well, and add water to 100ml.

[0035] Product properties:

[0036] The appearance of the obtained spray solution is clear, and the content measurement result shows that the acyclovir content is 2%. After bottling, each spray solution is 0.15ml, and the total number of sprays is about 100 times. Rabbits were used for skin irritation test and the result was non-irritating. It takes 15s for the spray liquid to form a drug film on the rabbit skin, and there is no loss of the drug solution.

Embodiment 3

[0038] Preparation Process:

[0039] Weigh 5g of sodium hyaluronate, dissolve it in an appropriate amount of water, add 10g of glycerin; weigh 1g of acyclovir, dissolve it in an appropriate amount of 0.1N NaOH solution; mix the two parts evenly, stir well, and add water to 100ml.

[0040] Product properties:

[0041] The appearance of the obtained spray solution is clear, and the content determination result shows that the content of acyclovir is 1%. After bottling, each spray solution is 0.2ml, and the total number of sprays is about 80 times. Rabbits were used for skin irritation test and the result was non-irritating. It takes 25s for the spray liquid to form a drug film on the rabbit skin, and there is no loss of the drug solution.

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PUM

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Abstract

The invention relates to the field of medicinal preparations, in particular to an in-situ formed acyclovir spraying agent and a preparation method thereof. The solution of the spraying agent comprises the following components in percentage by weight: 0.5 to 30 percent of acyclovir and 5 to 50 percent of temperature-sensitive polymer material. The mechanism of the in-situ formed gel is temperature-sensitive type, so the application range can be expanded to external application to skin, internal application to tracts and the like from application to eyes; the application to treatment of symptomis obviously increased; and the spraying agent is particularly applied to dermic administration and local external application to treating herpes simplex or shingles zoster infection and has wide market demand.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an acyclovir in-situ formed spray and a preparation method thereof. Background technique [0002] Aciclovir is a white crystalline powder, odorless and tasteless. It is very slightly soluble in water, slightly soluble in glacial acetic acid or hot water, and soluble in dilute sodium hydroxide solution. There may be interactions with some drugs and excipients. The dosage forms currently on the market include: 1) Solid preparations: Acyclovir tablets, Acyclovir dispersible tablets, Acyclovir sustained-release tablets, Acyclovir chewable tablets, Acyclovir capsules, Acyclovir Granules; 2) Liquid preparations: Acyclovir injection, Acyclovir for injection, Acyclovir eye drops; 3) Semi-solid preparations: Acyclovir eye ointment, Acyclovir cream, Acyclovir Gel, Acyclovir Ointment. Dosage forms under development include gastric retention dosage forms, osmotic pump controlle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/70A61K31/522A61K47/36A61K47/42A61K47/34A61K47/38A61P31/12A61P31/22
Inventor 吴国华杨燕王国华蔡月明李刚金琪谈国军倪建中黄伟强
Owner ZHEJIANG ZHEBEI PHARM CO LTD
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