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Couplet medicine extract for reducing sugar content and preventing diabetic angiopathy and preparation method thereof

An extraction method and extract technology, which can be used in cardiovascular system diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as undiscovered control drugs, and achieve the effect of improving the levels of internal and external factors in blood vessels, with good effects and high content of active ingredients.

Inactive Publication Date: 2011-10-05
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, judging from the current treatment status, the prevention and treatment of diabetic nephropathy by Western medicine is still in the exploratory stage, and no effective control drugs have been found.

Method used

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  • Couplet medicine extract for reducing sugar content and preventing diabetic angiopathy and preparation method thereof
  • Couplet medicine extract for reducing sugar content and preventing diabetic angiopathy and preparation method thereof
  • Couplet medicine extract for reducing sugar content and preventing diabetic angiopathy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The extraction process step of embodiment 1 medicine pair extract:

[0047] Weigh 200g of raw land and 100g of Cornus officinalis, decoct and extract with 8 times the amount of distilled water twice, 1 hour each time; filter the water extract of the above-mentioned medicine pair with gauze, centrifuge the filtrate at 3000rpm, combine the supernatant, and evaporate at 60°C Concentrate, evaporate to dryness in a water bath at 80°C, and dry under reduced pressure at 60°C to constant weight to obtain 213 g of the water extract of the drug pair.

Embodiment 2

[0048] The extraction process step of embodiment 2 medicine pair extract:

[0049] Weigh 300g of raw land and 150g of Cornus officinalis medicinal materials, decoct and extract with 10 times the amount of distilled water for 3 times, each time for 1.5 hours; filter the above water extracts with gauze, centrifuge the filtrate at 3500rpm, combine the supernatant, and evaporate at 55°C Concentrate, evaporate to dryness in a water bath at 85°C, and dry under reduced pressure at 55°C to constant weight to obtain 324 g of the water extract of the drug pair.

Embodiment 3

[0050] The extraction process step of embodiment 3 medicine pair extract:

[0051] Weigh 500g of raw land and 250g of Cornus officinalis, decoct and extract with 12 times the amount of distilled water for 3 times, 2 hours each time; filter the water extract of the above-mentioned medicine pair with gauze, centrifuge the filtrate at 4000rpm, combine the supernatant, and evaporate at 50°C Concentrate, evaporate to dryness in a water bath at 90°C, and dry under reduced pressure at 50°C to constant weight to obtain 542 g of the water extract of the drug pair.

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Abstract

The invention discloses a couplet medicine extract which is prepared by extracting radix rehmanniae and dogwood according to the weight ratio of 2:1. The preparation method of the couplet medicine extract comprises the following steps of: (1) weighing radix rehmanniae and dogwood, evenly mixing according to the weight ratio of 2:1, extracting for 2-3 times (1-2 hours every time) with distilled water of which the weight is 8-12 times of the weight of the medicinal materials; and (2) filtering the couplet medicine water extract with gauze, centrifuging the filtered solution, mixing the supernatant solutions, evaporating and concentrating in a rotating way, drying by distillation in a water bath, and drying under the reduced pressure to the constant weight to obtain the couplet medicine extract. The yield of the extract is 71.9%, and the content of total iridoid glycoside in the extract is 12.48%. The pharmacological test result shows that the extract has the functions of reducing sugar content, protecting blood vessels and improving the levels of the internal and external factors of the blood vessels, and has a unique function of protecting the kidney and heart. Thus, the couplet medicine extract provided by the invention can be used for preparing medicaments for reducing sugar content and preventing diabetic angiopathy.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to an extract used for lowering blood sugar and protecting diabetic vascular disease, a preparation method and application thereof. Background technique [0002] Diabetes belongs to the category of "diabetes syndrome" in traditional Chinese medicine. Diabetic vascular disease is the main complication of diabetes. The nature of its macrovascular disease is atherosclerosis, which mainly involves large blood vessels such as aorta and coronary artery. Diabetic microangiopathy is a chronic vascular complication unique to diabetes, mainly manifested as retinal , kidney and other microvascular diseases. According to statistics, there are about 41 million people with diabetes in my country. Clinical statistics show that 40%-50% of diabetic patients develop retinopathy 10 years after onset; about 2% of patients are completely blind 15 years after onset; End-stage renal disease. D...

Claims

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Application Information

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IPC IPC(8): A61P9/00A61K36/804A61P3/10
Inventor 许惠琴狄留庆吕高虹赵晓丽刘洪李祥吴诚沈存思
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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