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Aquogel scalding surgical dressing and preparation method thereof

A hydrogel and dimethyl sulfone technology, applied in the field of biochemistry, can solve the problems of low healing effect of scald wound, long wound healing time, and great pain of patients, and achieve accelerated wound healing, good biocompatibility and Wettability, pain-reducing effects for patients

Inactive Publication Date: 2011-10-19
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Although the existing hydrogel dressings have good biocompatibility and breathability and moisture permeability, and are easy to replace, they have the following defects as burn dressings: the healing effect on burn wounds is low, the wound healing time is long, and the wound It is often accompanied by labor pain before healing, and the patient still feels a lot of pain

Method used

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  • Aquogel scalding surgical dressing and preparation method thereof
  • Aquogel scalding surgical dressing and preparation method thereof
  • Aquogel scalding surgical dressing and preparation method thereof

Examples

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preparation example Construction

[0029] The embodiment of the present invention discloses a preparation method of a hydrogel burn dressing, comprising the following steps:

[0030] a), adding dimethyl sulfone to the polyethylene solution to obtain a mixed solution, the weight ratio of dimethyl sulfone to polyvinyl alcohol in the mixed solution is (0.01~10):100;

[0031] b), casting the mixed solution into a film;

[0032] c) performing repeated freezing and cross-linking on the cast film-forming solution to obtain a hydrogel burn dressing.

[0033] It can be seen from the above scheme that the method provided by the invention is to prepare a hydrogel dressing with polyvinyl alcohol (PVA) and dimethyl sulfone (MSM) as raw materials. The reason for the PVA selected by the present invention is: PVA has good biodegradability, biocompatibility, solvent resistance and film-forming property, has no toxic and side effects to the human body, and is an excellent biomedical material, so the present invention selects P...

Embodiment 1

[0047] 1. Prepare PVA solutions with a concentration of 8wt%, 12wt% and 15wt%, respectively, and heat to 100°C while stirring to completely dissolve the PVA in water.

[0048] 2. Freeze the three PVA solutions prepared in step 1 at -20°C for 20 hours, then take them out and thaw them at room temperature for 2 hours, repeat freezing and cross-linking 6 times in this way, and obtain PVA with concentrations of 8wt%, 12wt% and 15wt% respectively Hydrogel dressing.

[0049] Test the extensional stretch properties of the above three PVA hydrogel dressings, such as figure 1 Shown is the concentration of 8wt%, 12wt% and 15wt% of the PVA hydrogel dressing tensile strength histogram, as can be seen from the figure, 12wt% of the PVA hydrogel dressing has good elongation and tensile properties.

Embodiment 2

[0051] 1. Prepare a PVA solution with a concentration of 12wt%, and heat it to 100°C while stirring to completely dissolve the PVA, and cool the PVA solution to room temperature.

[0052] 2. In the state of slow stirring, add the MSM solution drop by drop into the PVA solution. The weight ratio of the MSM in the added MSM solution to the PVA in the PVA solution is 0.01:100. Soak to obtain a clear mixed solution.

[0053] 3. Pour the mixed solution obtained in step 3 into a film-making dish to cast a film.

[0054] 4. Freeze the film-forming solution in a refrigerator at -20°C for 20 hours, remove and thaw at room temperature for 2 hours, and repeat this 6 times to obtain a hydrogel burn dressing.

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Abstract

The invention provides an aquogel scalding surgical dressing and a preparation method thereof. The method comprises the following steps of: adding dimethyl sulphone into polyvinyl alcohol solution to obtain mixed solution, wherein a weight ratio of the dimethyl sulphone to the polyvinyl alcohol solution in the mixed solution is (0.01-10):100; performing film casting on the mixed solution; and freezing and crosslinking the solution subjected to film casting repeatedly to obtain the aquogel scalding surgical dressing. The aquogel scalding surgical dressing prepared according to the method has high biocompatibility and wettability, and can promote cell neogenesis, accelerate the healing of wounds, stop bleeding, relieve pain and reduce the pain of patients.

Description

technical field [0001] The invention relates to the technical field of biochemistry, in particular to a hydrogel burn dressing and a preparation method thereof. Background technique [0002] In daily life, people will damage the skin and produce wounds due to trauma, burns or surgery. In order to avoid external harmful microorganisms from infecting the wound and accelerate the healing of the wound, it is usually necessary to apply a medical dressing on the wound. A medical dressing is a wound dressing that is mainly used to cover sores, wounds or other damages to protect the wound, absorb secretions, reduce infection and promote healing. [0003] Traditional medical dressings are mainly made of gauze, cotton and other materials whose main function is to clean or protect the wound. This type of medical dressing can effectively protect the wound surface, has a strong ability to absorb exudate, and is low in cost, easy to obtain raw materials, and simple to make. reusable. B...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08J3/24A61L15/24A61L15/20A61L15/42
Inventor 章培标徐冰函崔巍巍陈学思崔立国王宇王宗良
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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