U-shaped hollow fiber pipe artificial liver bioreactor

Abstract

The invention discloses a U-shaped hollow fiber pipe artificial liver bioreactor. A plurality of hollow fiber pipes are uniformly encapsulated in parallel at the center in a transparent cylindrical vessel, the insides of the hollow fiber pipe from an inner cavity, an outer cavity is arranged outside the hollow fiber pipes, a patient plasma / blood inlet and a patient plasma / blood outlet of the inner cavity are respectively arranged at the two ends of the cylindrical vessel, a liver cell culture solution inlet and a liver cell culture solution outlet of the outer cavity are respectively arranged on the cylindrical surface of the cylindrical vessel in parallel; and the plurality of hollow fiber pipes are U-shaped hollow fiber pipes. The U-shaped hollow fiber pipe bioreactor disclosed by the invention can guarantee enough area so that liver cells are attached to the walls of the pipes to grow, and blood flow of the curved parts of the U-shaped pipes can generate secondary flow, thus the blood can be fully mixed; and the phenomena that plasma protein is adhered to the walls of the pipes in large amount to block the hollow fiber membrane holes can be avoided, thus being beneficial to detoxification and mass transfer of the hollow fiber, prolonging the supporting action time of an in vitro artificial liver and improving the treatment efficiency of an artificial liver.

Description

technical field [0001] The invention relates to an artificial liver bioreactor, in particular to a U-shaped hollow fiber tube artificial liver bioreactor. Background technique [0002] The bioreactor is the core device of the extracorporeal bioartificial liver support system. It is the place where exogenous liver cells exchange substances with the plasma / blood of patients with liver failure, and is the key part to play the role of artificial liver support. As a bioreactor, the following basic functions are required: two-way transmission of small and medium molecular substances, immune barrier of macromolecular substances of immunoglobulin, protection of liver cell activity and function, certain capacity and easy expansion. [0003] At present, the existing bioreactors used in the artificial liver system are generally hollow fiber bioreactors, that is, a plurality of hollow fiber tubes are packaged in a cylindrical container, and the hollow fiber tube divides the container in...

AI Technical Summary

Problems solved by technology

Hepatocytes are adherent cells, but generally the tubular shape of the hollow fiber bioreactor is a straight tube, which is not conducive to the growth of adherent hepatocytes in the extratube cavity

In addition, when the patient's plasma / blood flows in the straight tube, the flow field is consistent, there will be no secondary flow phenomenon, and the plasma / blood and the external cavity cannot perform sufficient material exchange

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