Preparation method of injection for treating cardio-cerebral vascular diseases
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A technology for cardiovascular and cerebrovascular diseases and injections, which can be applied to cardiovascular system diseases, medical preparations containing active ingredients, pharmaceutical formulas, etc. , less impurity content, and the effect of reducing blood viscosity
Inactive Publication Date: 2011-11-02
TIANSHENG PHARMA GROUP
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Currently, Xuesaitong Injection and Xueshuantong Injection, the intravenous drug of Panax notoginseng saponins, are widely used clinically. Since they are administered with pure Panax notoginseng saponins, the dosage of saponins is relatively large, and adverse reactions such as saponin hemolysis are also prone to occur in clinical practice.
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Embodiment 1
[0041] Embodiment 1, a kind of preparation method of the injection of treating cardiovascular and cerebrovascular diseases, is characterized in that: it comprises the following steps and is prepared from:
[0042] The first step is to prepare Panax notoginseng saponins:
[0043] a. Take 10kg of medicinal material Panax notoginseng, add 70% ethanol with a concentration of 10 times the volume percentage of the medicinal material, and reflux extraction at 80°C for 3 times, the first time is 3 hours, the second time is 2 hours, and the third time is 1.5 Hour, merge three alcohol extracts, get notoginseng alcohol extract;
[0044] B, the notoginseng alcohol extract that obtains in above-mentioned a is carried out preliminary clarification treatment; Described preliminary clarification treatment selects gauze to remove most of impurity;
[0045] c. Concentrate the Panax notoginseng extract that has been preliminarily clarified in b above, and then conduct macroporous resin separati...
Embodiment 2
[0067] Embodiment 2, a kind of preparation method of the injection of treating cardiovascular and cerebrovascular diseases, comprises the following steps:
[0068] The first step is to prepare Panax notoginseng saponins:
[0069] a. Take 15kg of medicinal material Panax notoginseng, add 70% ethanol with a volume percentage concentration 10 times that of the medicinal material, and reflux extraction at 80°C for 3 times, the first time is 3 hours, the second time is 2 hours, and the third time is 1 hour. Hour, merge three alcohol extracts, get notoginseng alcohol extract;
[0070] B, the notoginseng alcohol extract obtained in the above 1 is subjected to preliminary clarification treatment; the preliminary clarification treatment selects filter paper;
[0071] c. Concentrate the Panax notoginseng extract that has undergone preliminary clarification treatment in the above 2, and then carry out macroporous resin separation treatment, where the separation is preliminary purificati...
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Abstract
The invention discloses a preparation method of an injection for treating cardio-cerebral vascular diseases. The preparation method is characterized by comprising the following steps of: a, adding ethanol into a medical medicinal material such as panax notoginseng, heating for refluxing to prepare a panaxtriol extracting solution; b, primarily clarifying the panaxtriol extracting solution prepared in a; c, concentrating the panaxtriol extracting solution subjected to the primary clarification in b and separating through using macroporous resins, wherein the separation process is used for primary purification; and d, ultrafiltering the panaxtriol extracting solution subjected to the primary purification in c to prepare panax notoginseng saponins; and then processing the panax notoginseng saponins to prepare a finished product. The prepared injection for treating the cardio-cerebral vascular diseases has light colour, low content of impurities, high content of active ingredients, high bioavailability and good safety, is beneficial to absorption by a human body as well as can satisfy first-aid requirements of patients suffered from various cardio-cerebral vascular diseases such as cerebral thrombosis, cerebral infarction, stenocardia, myocardial infarction and the like; furthermore, the injection can be used as an excellent agent for inhabiting blood platelet congregating and has the efficacies of reducing blood viscosity and increasing cerebral blood flow.
Description
technical field [0001] The invention relates to an injection for treating cardiovascular and cerebrovascular diseases, in particular to a preparation method for the injection for treating cardiovascular and cerebrovascular diseases. Background technique [0002] Cardiovascular and cerebrovascular diseases are the number one killer that endangers human life and health. According to statistics, 17 million people died of cardiovascular diseases in the world in 2000, accounting for 1 / 3 of the total number of deaths from various causes in the world. It is estimated that by 2020 This number will increase to 25 million, 80% of which are in developing countries. Therefore, the prevention and treatment of cardiovascular and cerebrovascular diseases has been listed as one of the national key issues. With the increase of the incidence of cardiovascular diseases, it will be a very meaningful work to develop drugs that can effectively prevent and treat cardiovascular diseases. [0003] ...
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