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Breviscapine ethosome gel preparation and preparation method thereof

A technology for breviscapine and gel preparation, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve problems such as frequent dosing, and achieves increased cumulative transdermal volume, good effect, and simple preparation. Effect

Inactive Publication Date: 2011-11-09
珠海高新技术创业服务中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many drug administration methods for the treatment of cardiovascular diseases, such as oral administration, injection, etc., but due to the nature of the drug itself, it inevitably leads to the disadvantage of frequent administration.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Weigh 0.150g of breviscapine, 1.000g of soybean lecithin, 15ml of ethanol, and 85ml of PBS (pH=7.0), stir, sonicate, and pass through a microporous membrane to obtain breviscapine ethosome A. Take 5g of menthol and mix it evenly with 100ml ethosome to obtain A+B mixed solution.

[0031] Weigh 1g of Carbomer 980, swell with 15g of water, add triethanolamine dropwise at 1.5:1 (triethanolamine:carbomer; w / w), stir evenly to obtain a carbomer gel matrix, add an appropriate amount of ethanol ( Ethanol content is the same as ethanol content in ethosome) and 10g sorbitol, after mixing evenly, add 40g (A+B mixed solution), after stirring evenly, make up the balance with solvent to obtain 100g scutellarin ethosome gel preparation.

Embodiment 2

[0033] Weigh 0.35g of scutellarin, 3.000g of lecithin, 30ml of ethanol, and 70ml of PBS (pH=7.0), stir, sonicate, and pass through a microporous membrane to obtain scutellarin ethosome A. Take 1mL of azone and mix it with 99ml of ethosome to get A+B mixture.

[0034] Weigh 2 g of Carbomer 980, swell with 15 g of water, add triethanolamine dropwise at 1.5:1 (triethanolamine: carbomer; w / w), stir evenly to obtain a carbomer gel matrix, add an appropriate amount of ethanol ( Ethanol content is the same as ethanol content in ethanol body) and 5g glycerol, after mixing evenly, add 60g (A+B mixed solution), after stirring evenly, use solvent (ethanol water mixture, ethanol content and ethanol content in ethanol body Same) make up the balance to obtain 100g scutellarin elastosome gel preparation.

Embodiment 3

[0036] Weigh 0.35g of breviscapine, 1.000g of soybean lecithin, 45ml of ethanol, and 55ml of PBS (pH=7.0), stir, sonicate, and pass through a microporous membrane to obtain breviscapine ethosome A. Take 5mL of azone + 5g of borneol, and mix them with 95ml of ethosome to obtain the A+B mixture.

[0037] Weigh 1g of Carbomer 980, swell with 15g of water, add triethanolamine dropwise at 1.5:1 (triethanolamine:carbomer; w / w), stir evenly to obtain a carbomer gel matrix, add an appropriate amount of ethanol ( The ethanol content is the same as that in the ethanol plastid) and 10g of glycerol, after mixing evenly, add 75g (A+B mixed solution), after stirring evenly, make up the balance with solvent to obtain 100g scutellarin ethotopic gel preparation .

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Abstract

The invention relates to a breviscapine ethosome gel preparation and a preparation method thereof, belonging to the technical field of medicine. The breviscapine ethosome gel preparation disclosed by the invention is composed of breviscapine ethosome (A), a penetration enhancer (B) and a gel substrate, and can be used for transdermal administration. The breviscapine ethosome gel preparation uses a novel ethosome administration carrier, obviously improves the transdermal penetrating quality of the breviscapine, controls the drug release, improves the compliance of patients and also reduces the administration frequency and administration dosage.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a scutellarin ethosome gel preparation and a preparation method thereof. Background technique [0002] With the aging of the population, cardiovascular and cerebrovascular diseases have become the number one disease in the world, with a large patient population and a large demand for such drugs. Compared with chemically synthesized drugs, traditional Chinese medicine generally has the characteristics of moderate effect, relatively small toxic and side effects, and is suitable for long-term medication. Especially in the recovery and health care process of acute heart disease and cerebral infarction, traditional Chinese medicine preparations have unique advantages. Breviscapine (berviscpaine) is an active ingredient extracted from the plant Breviscapus [Ergeiorn bervlsPacus (Vant.) Hnad-MZZa] of Compositae. Clinically, it is widely used in the treat...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/7048A61P9/00A61P9/10A61P7/02
Inventor 王义明刘清飞朱敬杰林俊生从文娟史俊罗国字
Owner 珠海高新技术创业服务中心
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