Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for synthesizing pidotimod

A technology of pidotimod and a synthesis method, applied in the field of preparation of pharmaceutical compounds, can solve the problems of low yield and high production cost in the synthesis process, and achieve the effects of low price, low cost and reduced decomposition

Active Publication Date: 2011-11-09
QINGDAO VLAND BIOTECH INC
View PDF1 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to provide a synthetic process of pidotimod, which solves the problems of low yield and high production cost in the existing synthetic process

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for synthesizing pidotimod
  • Method for synthesizing pidotimod

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, preparation method of the present invention

[0030] Step 1, weigh 100g of L-thiazolidine-4-carboxylic acid and add it into 400mL of acetone, then add 114g of potassium carbonate and stir for 0.5h.

[0031] Step 2, dissolve 122g of L-pyroglutamyl chloride in 300mL of acetone, then dropwise add it to the solution obtained in step a and stir for 2h.

[0032] Step 3, filter, dissolve the filter cake in 500mL of water, ice-bath to 0-10 degrees, acidify the above solution with concentrated hydrochloric acid to PH = 2, a white precipitate is formed, continue to stir for 1 hour.

[0033] Step 4, filtering and drying. The crude product of pidotimod was obtained.

[0034] Step 5, the crude product of pidotimod is recrystallized with water, filtered, dried, and weighed to obtain 165g of refined pidotimod with a yield of 90%

Embodiment 2

[0035] Embodiment 2. preparation method of the present invention

[0036] Step 1, weigh 100g of L-thiazolidine-4-carboxylic acid and add it into 500mL of acetone, then add 96g of sodium carbonate and stir for 0.5h.

[0037] Step 2, dissolve 166g of L-pyroglutamyl chloride in 400mL of acetone, then dropwise add it to the solution obtained in step a and stir for 2h.

[0038] Step 3, filter, dissolve the filter cake in 500mL of water, ice-bath to 0-10 degrees, acidify the above solution with concentrated hydrochloric acid to PH = 2, a white precipitate is formed, continue to stir for 1 hour.

[0039] Step 4, filtering and drying. The crude product of pidotimod was obtained.

[0040] In step 5, the crude product of pidotimod was recrystallized with water, filtered, dried, and weighed to obtain 163g of refined pidotimod with a yield of 89%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for synthesizing pidotimod, which comprises the following steps of: mixing L-thiazolidine-4-carboxylic acid and an acid binding agent in anhydrous acetone; dripping an anhydrous acetone solution of L-pyroglutamic acyl chloride; after the reaction is finished, filtering; dissolving a filter cake in water, acidifying, and filtering to obtain a coarse product; and drying the coarse product, and recrystallizing to obtain the pidotimod.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical compound, in particular to a synthesis method of an immune enhancer pidotimod. Background technique [0002] Pidotimod (pidotimod) was developed by the Italian company Poli industria chimica S.P.A in the 1980s and was approved for clinical use in 1993. It is a synthetic immune booster with a structure similar to that of a dipeptide. Its chemical name is For (R)-3-(S)-(5-oxo-2-pyrrolidinyl)carbonyl]-tetrahydrothiazole-4-carboxylic acid. It has the advantages of rapid distribution and excretion, no accumulation in the body, and good tolerance. It can not only promote non-specific immune responses, but also promote specific immune responses. At present, it has been listed in many countries in Asia, Europe, America, etc., and is mainly used to treat bacteria (pneumococcus, Escherichia coli, Pseudomonas aeruginosa, Proteus, etc.) and viruses (influenza virus) by promoting the body's immune f...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07K5/078
Inventor 林扬姚德勇郝智慧贾德强王艳玲
Owner QINGDAO VLAND BIOTECH INC
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com