Lung-kidney deficiency type lung cancer mouse model

Abstract

The invention belongs to the technical field of Chinese medicine lung cancer syndrome and relates to a building method for a lung-kidney deficiency type lung cancer mouse model. The lung-kidney deficiency type lung cancer mouse model can be used for preparing an animal model of lung-kidney deficiency type lung cancer disease combination. In the model, a preparation method that a mouse lung Qi deficiency and kidney deficiency model and a Lewis lung cancer cell transplantation tumor model are used for joint molding is adopted, i.e., a Lewis lung cancer cell is subjected to subcutaneous injection to build a lung cancer transplantation tumor model, a smoked stimulation method is adopted for building a lung Qi deficiency model, and hydrocortisone is subjected to intraperitoneal injection to build a lung deficiency model. The model is simple to operate, has the advantages of short molding period, high success rate and good repeatability and stability, and withstands the measurement and verification by a prescription (medicine). Most importantly, the model conforms to the pathologic features of lung cancer and has the characteristics of the Chinese medicine theory. The Chinese medicine theoretical knowledge can be combined to comprehensively analyze the scientificity of the mouse lung-kidney deficiency type lung cancer animal model, thus a scientific research tool is provided for researching the lung cancer resistance of the traditional Chinese medicine.

Description

technical field [0001] The invention belongs to the technical field of lung cancer syndrome research in traditional Chinese medicine, and in particular relates to a mouse model of lung and kidney deficiency type lung cancer, which can be used for the preparation and evaluation of lung cancer lung and kidney deficiency type lung cancer disease-syndrome combined animal models. Background technique [0002] Lung cancer is one of the most common malignant tumors that seriously endanger human life and health, and its morbidity and mortality rank first among malignant tumors. In recent years, the research on how to prevent and treat lung cancer has become the focus of international academic circles, and it is also an important research content in the research field of "population and health", which is urgently needed and needs to be developed in my country. Traditional Chinese medicine treatment of advanced lung cancer has the characteristics of safety and few side effects, which ...

AI Technical Summary

Problems solved by technology

The establishment of an animal model of lung cancer with both lung and kidney deficiency has far-reaching significance for the research on the mechanism of anti-lung cancer effect of traditional Chinese medicine. Unfortunately, there is no report on the animal model of lung cancer with both lung and kidney deficiency

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