Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of compound albuterol sulfate and ambroxol hydrochloride inhalation solution

A technology of albuterol sulfate and ambroxol hydrochloride, which is applied in the fields of pharmaceutical formulations, respiratory diseases, drug delivery, etc., and can solve the problems of low bioavailability of oral preparations

Inactive Publication Date: 2011-11-30
BEIJING RUNDEKANG MEDICAL TECH CO LTD
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Pharmacokinetic studies have proved that it metabolizes rapidly in the body, excretes quickly, and has low bioavailability of oral preparations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of compound albuterol sulfate and ambroxol hydrochloride inhalation solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] prescription:

[0019] Component A:

[0020] Salbutamol sulfate (as salbutamol) 2mg

[0021] Ambroxol Hydrochloride 7.5mg

[0022] Mannitol 0.580g

[0023] Made a total of 1

[0024] Component B:

[0025] Purified water 5ml

[0026] Made a total of 1

[0027] Preparation:

[0028] Take albuterol sulfate and ambroxol hydrochloride, pulverize them through a 100-mesh sieve, mix them uniformly according to the method of equal increase, and pack them into 5ml neutral borosilicate brown control bottles under aseptic conditions, which is component A;

[0029] Take purified water and pack it into 5ml ampoules, which is component B.

[0030] During treatment, add component B to component A, shake to dissolve to obtain a clear and transparent solution, add this solution to the inhalation nebulizer, and inhale.

Embodiment 2

[0032] prescription:

[0033] Component A:

[0034] Salbutamol sulfate (as salbutamol) 2g

[0035] Ambroxol Hydrochloride 7.5g

[0036] Mannitol 280g

[0037] A total of 1000 pieces were made

[0038] Component B:

[0039] Purified water 5000ml

[0040] A total of 1000 pieces were made

[0041] Preparation:

[0042] 1. Get ambroxol hydrochloride and pulverize it through a 100-mesh sieve for subsequent use.

[0043] 2. Take about 4000ml of purified water, add salbutamol sulfate, ambroxol hydrochloride, and mannitol in sequence, stir to dissolve, and add purified water to the full amount.

[0044] 3. Divide the above solution into 5ml neutral borosilicate brown vials, each bottle is 5ml, half-stoppered, and freeze-dried in a freeze dryer to obtain a freeze-dried powder. For component A.

[0045] 4. Pack the purified water into 5ml ampoules, 5ml per bottle, which is component B.

[0046] 5. During treatment, add component B to component A, shake to dissolve, and get a ...

Embodiment 3

[0048] prescription:

[0049] Component A:

[0050] Salbutamol sulfate (calculated as salbutamol) 0.5g

[0051] Ambroxol Hydrochloride 2.5g

[0052] Mannitol 280g

[0053] A total of 1000 pieces were made

[0054] Component B:

[0055] Purified water 5000ml

[0056] A total of 1000 pieces were made

[0057] Preparation:

[0058] 1. Get ambroxol hydrochloride and pulverize it through a 100-mesh sieve for subsequent use.

[0059] 2. Take about 4000ml of purified water, add salbutamol sulfate, ambroxol hydrochloride, and mannitol in sequence, stir to dissolve, and add purified water to the full amount.

[0060] 3. Divide the above solution into 5ml neutral borosilicate brown vials, each bottle is 5ml, half-stoppered, and freeze-dried in a freeze dryer to obtain a freeze-dried powder. For component A.

[0061]4. Pack the purified water into 5ml ampoules, 5ml per bottle, which is component B.

[0062] 5. During treatment, add component B to component A, shake to dissolve...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A compound salbutamol sulfate and ambroxol hydrochloride inhalation solution. The invention relates to an inhalation solution with salbutamol sulfate and ambroxol hydrochloride as active components and a preparation method thereof. The purpose of the present invention is to provide a kind of bioavailability that can improve medicine to vast patients and medical worker, bring into play medicine curative effect fully, reduce untoward reaction, preparation method is simple, is suitable for the new preparation of large-scale production -- salbutamol sulfate and hydrochloric acid Ambroxol inhalation solution. The present invention uses albuterol sulfate and ambroxol hydrochloride as active components, adds some specific types and proportions of auxiliary materials, and prepares the inhalation solution according to the conventional technology of pharmacy.

Description

technical field [0001] The invention relates to a compound salbutamol sulfate and ambroxol hydrochloride inhalation solution. In particular, an inhalation solution of albuterol sulfate and ambroxol hydrochloride for respiratory diseases and a preparation method thereof. Background technique [0002] Respiratory system disease is a common and frequently-occurring disease that endangers people's health, and its incidence rate accounts for the first among many diseases in any age group. According to data from the Statistical Yearbook of the United States, among all causes of death, the cause of death related to respiratory diseases (excluding tumors) rose from the 10th in 1970 to the 4th in 1991 (chronic obstructive pulmonary disease). and No. 8 (pneumonia, influenza and upper respiratory tract infection). The British Society for Thoracic Surgery pointed out in a recent research report that respiratory diseases have replaced cancer and heart disease as the disease with the hi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/137A61K9/08A61P11/06A61P11/14
Inventor 不公告发明人
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com