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One-step synthesis of sorbitan oleate and Span-80 pharmaceutical excipients

A technology of sorbitan oleate and pharmaceutical excipients, which is applied in the field of nonionic surfactants, can solve the problems of product internal regularity, lack of fluidity, and increased costs, and achieve good internal regularity, low cost, and low temperature. Effect

Inactive Publication Date: 2011-11-30
GUANGDONG ZHAOQING CHAONENG IND
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AI Technical Summary

Problems solved by technology

However, the internal regularity and fluidity of the products obtained by these two catalysts are lacking.
[0005] In "Synthesis of high-quality sorbitan monooleate" (Mao Lianshan, Wang Jiaguo, Xiang Zhaowang, Yang Subin, Li Guoyun; "Chemical Times"; May 2005, Volume 19, Issue 5) proposed the first etherification Synthesis of Span-80 by post-esterification two-step method, but the two-step method and the sub-step method will increase the cost compared with the one-step method

Method used

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  • One-step synthesis of sorbitan oleate and Span-80 pharmaceutical excipients
  • One-step synthesis of sorbitan oleate and Span-80 pharmaceutical excipients

Examples

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Embodiment Construction

[0016] An implementation example of the present invention is: take 0.5 parts of sorbitol with a water content of 30%, put it into a reactor, dehydrate it under vacuum, and directly add 1-1.2 parts of oleic acid and a high-efficiency composite catalyst when the temperature rises to 80°C (The main ingredients are high-purity potassium hydroxide and purified water). Control the temperature of the reaction process at 190-240°C, control the vacuum degree above 0.098MPA, and take 5-8 hours. After the reaction is completed, add medicinal activated carbon and activated clay to carry out Adsorption, decolorization, and filtration can obtain products with light color, internal regularity, and good fluidity. Its main indicators are as follows:

[0017]

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Abstract

The production process of synthesizing sorbitan oleate and Span-80 pharmaceutical excipients in one step, the invention is to vacuum dehydrate sorbitol with a water content of 30% in a reaction kettle, and directly add oleic acid and high-efficiency The composite catalyst carries out etherification and esterification reactions. The temperature of the reaction process is controlled at 190-240°C, the vacuum degree is controlled above 0.098MPA, and the time is 5-8 hours. After the reaction is completed, medicinal activated carbon and activated clay are added for adsorption, After decolorization and filtration, the product can be formed. The process has low reaction temperature and low cost, and the produced product has light color, good internal regularity and good fluidity.

Description

technical field [0001] The present invention relates to a nonionic surfactant. Background technique [0002] Pharmaceutical excipients Sorbitan oleate (also known as Span-80, Span-80 or sorbitan monooleate) is widely used as emulsifier and thickener in the fields of medicine, biological products, food, cosmetics and chemical industry Agents, dispersants, anti-fogging agents, penetrating agents, etc. In recent years, this product has been widely used in biological products, especially in the production of vaccines. [0003] At present, the production method of this product in our country is first etherification and then esterification step by step and one-step production. The traditional one-step alkali-catalyzed process is mainly used in China, and the quality is unstable. It can only be used in petroleum, mining and fiber industries. Most of these products used in food, medicine and cosmetics rely on imports. On the national patent network, there is only a description of ...

Claims

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Application Information

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IPC IPC(8): C07D307/20B01J23/04
Inventor 叶剑强
Owner GUANGDONG ZHAOQING CHAONENG IND
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