Optical fiber sensor-molecular imprinting online detection method for detecting propofol in biological samples and optical fiber sensor-molecular imprinting online detection device.

A molecular imprinting and optical fiber sensing technology, applied in the fields of fluorescence/phosphorescence, analytical materials, material excitation analysis, etc., can solve the problems of error in results, complicated and time-consuming sampling and detection process, changes in composition, etc., to achieve a simple method and avoid dispersion. Incoherence and results errors, well-structured effects

Inactive Publication Date: 2014-07-09
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a method for online detection of propofol in biological samples by optical fiber sensing molecular imprinting and an online detection device for optical fiber sensing molecular imprinting, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the complicated and time-consuming sampling detection process , and during the storage of the sample, the composition will change, causing the problem of error in the result

Method used

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  • Optical fiber sensor-molecular imprinting online detection method for detecting propofol in biological samples and optical fiber sensor-molecular imprinting online detection device.
  • Optical fiber sensor-molecular imprinting online detection method for detecting propofol in biological samples and optical fiber sensor-molecular imprinting online detection device.

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Embodiment 1

[0023] Embodiment 1, as attached figure 1 , 2 As shown, the optical fiber sensing molecular imprinting online detection device includes a solution test bottle, a connecting standpipe 1, a suction pump 2, a horizontal pipe 3, a liquid storage pipe 4, a switch valve 5, an optical fiber concentrator 6, and a right connecting pipe 8 and the left connecting pipe 9; the upper ends of no less than three solution test bottles are respectively fixedly equipped with a connecting standpipe 1, and the liquid inlet end of the suction pump 2 is fixedly installed with a level tube communicating with the liquid inlet of the suction pump 2 The pipe 3 and the upper end of the connecting standpipe 1 are respectively connected and connected with the horizontal pipe 3, a valve is fixedly installed on the connecting standpipe 1, and a liquid storage pipe 4 is fixedly installed at the liquid outlet of the suction pump 2. The lower end of the liquid storage tube 4 is fixedly equipped with a switchin...

Embodiment 2

[0030] Example 2, the method for on-line detection of propofol in biological samples using the optical fiber sensing molecular imprinting on-line detection device for optical fiber sensing molecular imprinting is carried out as follows: firstly, plasma samples, distilled water and methanol are respectively loaded into the plasma samples In the test bottle 14, the distilled water test bottle 13 and the methanol test bottle 12, during work, a set amount of propofol molecularly imprinted polymer is filled in the liquid storage tube 4; the three-way switching valve 15 for controlling the blood sample is opened, and the The suction pump 2 is turned on, and the plasma sample enters the liquid storage tube 4 through the suction pump 2. At this time, the switch valve 5 is in a closed state; when the sample height in the liquid storage tube 4 reaches the set amount, the suction pump 2 is turned off. , so that the plasma sample no longer flows into the liquid storage tube 4; shake the li...

Embodiment 3

[0031] Example 3, the method for on-line detection of propofol in biological samples using the optical fiber sensing molecular imprinting on-line detection device for optical fiber sensing molecular imprinting is carried out as follows: first, plasma samples, distilled water and methanol are respectively loaded into the plasma samples In test bottle 14, distilled water test bottle 13 and methanol test bottle 12, when working, fill about 20 mg of propofol molecularly imprinted polymer in liquid storage tube 4; The pump 2 is turned on, and the plasma sample enters the liquid storage tube 4 through the suction pump 2, and the switch valve 5 is in a closed state at this time; when the sample height in the liquid storage tube 4 reaches 2 mL, the suction pump 2 is turned off, and the plasma sample No longer flow into the liquid storage tube 4; shake the liquid storage tube 4 for two minutes to make the polymer fully contact with the plasma sample, at this time, the propofol in the bi...

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Abstract

An optical fiber sensor-molecular imprinting online detection method for detecting propofol in biological samples and an optical fiber sensor-molecular imprinting online detection device. The device provided by the invention comprises solution assay flasks, connection standpipes, a suction pump, a horizontal pipe, a liquid storage pipe, a switch valve, a fiber optically focused instrument, a right connecting pipe and a left connecting pipe. The device provided by the invention has a reasonable and compact structure; the method provided by the invention is simple and is easy to operate; according to the invention, continuous real-time online long-distance monitoring can be realized so as to enable the detection of propofol in the biological samples to be simpler, more time-saving and accurate; the interference of complex components in the biological samples is minimized and the detection efficiency is also greatly raised, thus completing the pretreatment and detection of the propofol-containing biological samples within minutes; as the optical signal transmission of propofol is completed by the utilization of optical fiber chemical sensing, the fine property and bendability of the optical fiber enable to simplify the rigid structure of instruments and equipment and continuously complete the pretreatment and detection of the samples at a time, thus avoiding the decentralization and incoherence of sampling analysis as well as result errors in present methods.

Description

technical field [0001] The invention relates to the technical field of propofol detection in organisms, and relates to a method for on-line detection of propofol in biological samples by optical fiber sensing molecular imprinting and an on-line detection device for optical fiber sensing molecular imprinting. Background technique [0002] Propofol, namely 2,6-diisopropylphenol, is an intravenous anesthetic discovered in 1970, first clinically tested in 1977, and approved by the FDA for clinical application in 1989. Short time, rapid recovery and other characteristics, known as the "cross-century" new type of intravenous anesthetic. At present, it is widely used in clinical anesthesia and ICU sedation at home and abroad. [0003] At present, HPLC, gas phase-mass spectrometry, and fluorescence spectrometry are mostly used to detect the concentration of propofol in biological samples. Most of these methods are sampling analysis, that is, sample collection, sample pretreatment, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64G01N35/08
Inventor 李莉丁海燕李魏嶙
Owner XINJIANG MEDICAL UNIV
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