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Application of geranylgeranylacetone to preparation of medicament for preventing and/or treating opiates drug addiction

A technology of teprenone and opioids, applied in the field of teprenone, achieves the effect of high safety, low price and reducing economic burden

Inactive Publication Date: 2011-12-07
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether teprenone can be, or is used to prevent and / or treat opioid addiction has not been reported

Method used

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  • Application of geranylgeranylacetone to preparation of medicament for preventing and/or treating opiates drug addiction
  • Application of geranylgeranylacetone to preparation of medicament for preventing and/or treating opiates drug addiction
  • Application of geranylgeranylacetone to preparation of medicament for preventing and/or treating opiates drug addiction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Experiment of teprenone antagonizing morphine-induced increase in autonomic activity

[0018] The experimental animals used in the experiment are: SPF grade C57BL / 6 mice, male, 6-7 weeks old, weighing 22-25 g, provided by the Experimental Animal Center of Chongqing Medical University. Mice were housed in isolation in single cages, fed special feed, and had free access to food and water.

[0019] The drugs used in the experiment were: teprenone (produced by Japan Eisai Company, molecular weight 330.55), and morphine hydrochloride injection (Northeast Pharmaceutical Group Company, Shenyang No. 1 Pharmaceutical Factory).

[0020] Measured with a small animal autonomous activity detection device. Mice were divided into 3 groups with 6 mice in each group. The control group (saline) was intragastrically administered normal saline for 7 consecutive days; the morphine group (Mor) was intragastrically administered normal saline for 7 consecutive days; the GGA and ...

Embodiment 2

[0021] Example 2: Teprenone antagonizes the place preference behavior induced by morphine

[0022] Experimental animals and medicines used in the experiment are the same as Example 1.

[0023] The place preference experimental device is composed of two boxes of exactly the same size (each box size is 15×15×30 cm), with a closable hole in the middle. The two boxes are white, smooth floor and black, grained rough floor. Mice were divided into 4 groups (6 in each group): control group (saline), morphine group (Mor), GGA and morphine group (GGA+Mor) GGA group. Saline group and Mor group were given normal saline by intragastric administration for 7 consecutive days in advance, GGA+Mor group and GGA group were given GGA (800 mg / kg) by intragastric administration for 7 consecutive days in advance. Among them, on the 5th and 6th day, after the intragastric injection, the mice were put into the position preference experiment device, moved freely between the two boxes, and adapted f...

Embodiment 3

[0024] Example 3: Teprenone relieves withdrawal symptoms in morphine-addicted mice induced by naloxone

[0025] Experimental animals and medicines used in the experiment are the same as Example 1.

[0026] Mice were divided into 4 groups (6 in each group): control group (saline), morphine group (Mor), GGA and morphine group (GGA+Mor) GGA group. Saline group and Mor group were given normal saline by intragastric administration for 7 consecutive days in advance, GGA+Mor group and GGA group were given GGA (800 mg / kg) by intragastric administration for 7 consecutive days in advance. From the 8th day to the 14th day, the Saline group and the Mor group were intragastrically administered with normal saline, the GGA+Mor group and the GGA group were intragastrically administered with GGA (800 mg / kg), and 2 hours later, the Saline group and the GGA group were intraperitoneally injected with normal saline , Mor group and GGA+Mor group received intraperitoneal injection of morphine (da...

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Abstract

The invention discloses application of geranylgeranylacetone to the preparation of a medicament for preventing and / or treating opiates drug addiction, relating to the technical field of medicines. Geranylgeranylacetone is taken as a medicament for preventing and treating the opiates drug addiction or is used for preparing a medicament for preventing and treating the opiates drug addiction. One or more medicinally acceptable conventional medicinal auxiliary materials can also be added into geranylgeranylacetone to prepare capsules, pills, powder, tablets, granules, oral liquids, injections and the like. Geranylgeranylacetone has the effects of antagonizing conditioned place preference behaviors caused by morphine and increase in autonomic activities induced by morphine and relieving the function of abstinence symptom action, is used for preventing and treating the opiates drug addiction, and has the advantages of remarkable curative effect, high safety, addiction resistance, low price, capability of lowering the economic burden of a patient, and the like.

Description

technical field [0001] The invention relates to a use of teprenone, in particular to a new medical use of teprenone in the preparation of drugs for preventing and / or treating opioid drug addiction, and belongs to the technical field of medicine. Background technique [0002] Opioid abuse is one of the social hazards of the world today. Common opioids include morphine, heroin, and opium. Opioid drug addiction refers to the formation of mental and physical dependence after repeated use of opioid drugs, and severe withdrawal symptoms after drug withdrawal. It is a chronic recurrent brain disease. The treatment for opioid addiction is detoxification, which consists of three organically linked links: detoxification, relapse prevention, and social reintegration. Detoxification is the basis of detoxification treatment, specifically referring to the process of giving drug addicts drug treatment or controlling their detoxification reactions in order to alleviate the withdrawal reac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/121A61P25/36
Inventor 白洁罗富成齐磊吕涛刘华
Owner KUNMING UNIV OF SCI & TECH
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