A film-forming waterproof and breathable wound protection liquid and its preparation method

A waterproof, breathable, film-forming technology, used in pharmaceutical formulations, aerosol delivery, medical science, etc., can solve the problems of secondary wound surface damage, poor air permeability, lack of air permeability, etc., to achieve convenient carrying and use, and conducive to stability , easy to use effect

Inactive Publication Date: 2011-12-14
夏敬民 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these products have some deficiencies, such as antibacterial drug resistance; the wound healing cannot be observed at any time under the condition of dressing, and frequent dressing changes are required, and the wound may be damaged twice during dressing changes; the dressing site and its surroundings are easily damaged. Avoid washing with water, which is not conducive to cleaning the patient's body surface and is prone to infection; poor toughness restricts joint activities; lack of air permeability is not conducive to wound healing with more exudation, etc., which affect wound healing and increase medical costs
[0003] Polyvinyl butyral contains longer branched chains, so it has good toughness, softness and flexibility, and is also hydrophobic so it has a waterproof effect. It can be used as a film-forming material in medicine, but its film-forming The air permeability is poor, which is not conducive to the diffusion and exudation of drugs and the drying of the wound surface; glycerin and polyvinylpyrrolidone are hydrophilic polymer substances, which can play a water-soluble pore-forming role in the membrane material, and can moisturize the wound surface when it is dry Glycerin also has an antifreeze effect, polyvinylpyrrolidone forms a film when dry to prevent excessive drying of the wound due to water evaporation; ethanol can be used as a solvent and has a disinfection effect
However, the compound preparation of these ingredients has not been effectively applied in wound protection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) A film-forming waterproof and breathable wound protection liquid, which is mainly composed of film-forming materials, solvents, mixed porogens and preservatives. The weight composition of the raw materials for preparing the film-forming agent is: polyvinyl butyral acetal 120 grams, 830 grams of ethanol, 12 grams of glycerin, 10 grams of polyvinylpyrrolidone, appropriate amount of preservatives;

[0028] (2) A method for preparing a film-forming waterproof and breathable wound protection fluid for protecting wound surfaces, comprising the following steps:

[0029] ① Weigh an appropriate amount of preservative, 10 grams of polyvinylpyrrolidone, and 12 grams of glycerin, and add them to 200 ml of ethanol, and stir to fully dissolve them to obtain liquid A;

[0030] ② Weigh 120 grams of polyvinyl butyral, add it to 600 ml of ethanol, stir while adding to make it fully swell;

[0031] ③ Add liquid A to the swollen polyvinyl butyral, add ethanol to a sufficient amount, s...

Embodiment 2

[0037] (1) An aerosol film-forming waterproof and breathable wound protection liquid, which is mainly composed of film-forming materials, solvents, mixed porogens, preservatives and propellants. The raw materials for preparing 1000 grams of aerosol film-forming preparations are: 100 grams of polyvinyl butyral, 600 grams of ethanol, 11 grams of glycerin, 8 grams of polyvinylpyrrolidone, appropriate amount of preservatives, and 281 grams of 9:1 propane butane propellant.

[0038] (2) The preparation method of the aerosol film-forming waterproof and breathable wound protection liquid for protecting the wound surface, comprising the following steps:

[0039] ① Weigh an appropriate amount of preservative, 9 grams of polyvinylpyrrolidone, and 11 grams of glycerin, and add them to 150 ml of ethanol, and stir while adding to fully dissolve to obtain liquid A;

[0040] ② Weigh 100 grams of polyvinyl butyral, add it to 500 ml of ethanol, stir while adding to make it fully swell;

[004...

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Abstract

The invention relates to a film-forming waterproof and breathable wound protection liquid and a preparation method thereof. The wound protection liquid has two dosage forms of a coating type and an aerosol film-forming type, and mainly consists of a film-forming material, a solvent, a mixed porogen and a preservative Composition, the content of each component is 50-140 grams of film-forming material, 530-850 grams of solvent, 10-30 grams of mixed porogen, and aerosol film-forming type with additional propellant; the preparation method is to mix Add the porogen into ethanol, and dissolve to obtain liquid A, polyvinyl butyral, add it to ethanol, and swell to obtain polyvinyl butyral liquid, add liquid A to the swollen polyvinyl butyral liquid, and dissolve to obtain Liquid B, filled and packaged to get the finished product of film-coated wound protection liquid, put B into the propane-butane propellant to obtain aerosol film-forming wound protection liquid; It plays an effective protective role, can promote the formation of scabs, isolate microorganisms, inhibit bacteria, waterproof and breathable, and is transparent after film formation, so that the wound healing can be observed at any time without frequent dressing changes.

Description

technical field [0001] The invention relates to a wound-protecting liquid and a preparation method thereof, in particular to a waterproof and breathable wound-protecting product in the form of film-coating and aerosol film-forming preparations, and mainly belongs to the technical field of surgical medical instruments. Background technique [0002] Open wounds include surgical incisions and burns. The current treatment of wounds is to use antibacterial and anti-inflammatory drugs plus dressings, wound drug patches, ointments, and wound adhesives after debridement and suture, which have good antibacterial effects on wounds. Anti-inflammatory and wound protection, some also have certain hemostatic and analgesic effects. However, these products have some deficiencies, such as antibacterial drug resistance; the wound healing cannot be observed at any time under the condition of dressing, and frequent dressing changes are required, and the wound may be damaged twice during dressin...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/24A61L15/20A61K9/00A61K9/12A61P17/02
Inventor夏敬民
Owner夏敬民