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Method for preparing benzylamine

A technology of benzylamine and methylbenzylamine, applied in the field of aromatic nitrile preparation of benzylamine, can solve the problems of potential safety hazards, high pressure of hydrogenation process, high price of reducing agent, etc., and achieve less potential safety hazards, low equipment cost and mild conditions Effect

Inactive Publication Date: 2013-08-07
ZHEJIANG UNIV
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Problems solved by technology

Among them, the required pressure of the hydrogenation method is high, the equipment cost is high, and there are potential safety hazards; the price of the reducing agent used in the hydrazine reduction method is relatively high (the reducing agent in the hydrazine reduction method is hydrazine monoformate (HCOON 2 h 5 ), the mol ratio between the reducing agent and the compound shown in formula II is about 5:1 during the reaction

Method used

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  • Method for preparing benzylamine
  • Method for preparing benzylamine
  • Method for preparing benzylamine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation method of amine

[0014] Using 80 mL of ethylene glycol dimethyl ether as a solvent, add 0.05 mol of benzonitrile (about 5.2 g), 0.15 mol of sodium methoxide (about 8.1 g), and 0.005 mol of Raney copper, stir and heat to 50°C for 3 hours. After the reaction, the reaction solution was cooled to room temperature, filtered, and distilled to collect fractions at 184-186°C to obtain 4.8 g of amine with a yield of 89.0%.

Embodiment 2-8

[0016] Change the kind (abbreviation R1, its molar weight constant), solvent kind (abbreviation S), solvent consumption (V), reductant kind (abbreviation R2) and consumption of aromatic nitrile (being the compound shown in formula II) in the embodiment 1 (abbreviated as m2), reaction temperature (abbreviated as T), reaction time (abbreviated as t), collecting temperature is the cut of T ', and the yield that obtains corresponding amine M is Y, and detailed data is shown in Table 1.

[0017] Table 1

[0018]

[0019]

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PUM

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Abstract

The invention discloses a method for preparing benzylamine. The method comprises the following steps: a compound shown as the formula (II) described in the specification and sodium alkoxide are reacted in an organic solvent under the catalysis of rennie copper, wherein the mol ratio of the sodium alkoxide to the compound shown as the formula (II) is (2-4):1, the use amount of the rennie copper is0.05-0.15 time of the molar weight of the compound shown as the formula (II), the reaction temperature is 30-70 DEG C and the reaction time is 2-6 h; after reacting, the temperature of the obtained reaction liquid is decreased to room temperature; then, the reaction liquid is filtered; and the filtrate is distilled to obtain the compound shown as the formula (I) described in the specification.

Description

technical field [0001] The present invention relates to a kind of method for preparing amine by aromatic nitrile. Background technique [0002] Bianamine is a chemical synthesis intermediate, which is an important raw material for the synthesis of some medicines, pesticides, dyes and other chemicals. There are many methods for preparing bianium amine, and the preparation of bianium amine by the reduction of aromatic nitriles involved in this paper is an important method. The method for preparing amine from aromatic nitriles reported in literature has hydrogenation method (Journal of Catalysis, 274 (2), 176-191, 2010; Journal of Materials Science, 45 (9), 2484-2493, 2010), hydrazine reduction Law (Synthetic communications, 33(2), 281-289, 2003) and so on. Among them, the required pressure of the hydrogenation method is high, the equipment cost is high, and there are potential safety hazards; the price of the reducing agent used in the hydrazine reduction method is relativel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07B43/04C07C211/27C07C211/49C07C211/29C07C209/48C07C213/02C07C217/58C07C221/00C07C225/16
Inventor 陈新志周少东钱超
Owner ZHEJIANG UNIV
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