Production method of malonic acid mono-p-nitrobenzyl ester as penem medicament intermediate
A technology of p-nitrobenzyl ester and p-nitrobenzyl malonate, which is applied in the field of penem drug intermediate p-nitrobenzyl malonate, which can solve the problems of high raw material cost, high price of nitrobenzyl alcohol and no market Competitiveness and other issues, to achieve the effect of high product yield, simple process and easy operation
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Embodiment 1
[0014] In a 1000 ml three-necked flask equipped with a stirrer, a thermometer and a reflux condenser, add 296 grams of disodium malonate, 172 grams of p-nitrobenzyl chloride, 400 milliliters of acetonitrile, 101 grams of triethylamine, and stir under reflux 10 hours, then add 300 milliliters of water and stir, filter, the filtrate is layered, the oil layer is washed with aqueous sodium carbonate solution, and then washed with saturated brine to PH7, after distillation and concentration, a solid product is obtained, which is refined and dried with water to obtain 140 grams of the product, with a content of 98.5 %.
Embodiment 2
[0016] In a 1000 ml three-neck flask equipped with a stirrer, a thermometer and a reflux condenser, add 296 grams of disodium malonate, 172 grams of p-nitrobenzyl chloride, 400 milliliters of toluene, 101 grams of triethylamine, and stir to reflux 10 hours, then add 300 milliliters of water and stir, filter, the filtrate is layered, the oil layer is washed with aqueous sodium carbonate solution, and then washed with saturated brine to PH7, after distillation and concentration, a solid product is obtained, which is refined and dried with water to obtain 180 grams of the product, with a content of 98.5 %.
Embodiment 3
[0018] In a 1000 ml three-necked flask equipped with a stirrer, a thermometer and a reflux condenser, 296 grams of disodium malonate, 172 grams of p-nitrobenzyl chloride, 400 milliliters of toluene, 101 grams of triethylamine, 10 grams of Stir and reflux p-toluenesulfonic acid for 10 hours, then add 300 ml of water to stir, filter, and separate layers of the filtrate. The oil layer is washed with aqueous sodium carbonate solution, and then washed with saturated brine to pH 7. After distillation and concentration, a solid product is obtained, which is refined and dried with water to obtain Product 195 grams, content 98.5%.
[0019]
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