Silk-fibroin-coated polypropylene mesh and preparation method thereof
A technology of polypropylene mesh and silk protein, which is applied in the direction of coating, etc., to achieve the effect of reducing medical costs, enhancing tensile performance, and the process is simple and easy
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[0036] The preparation method of the silk protein-coated polypropylene mesh comprises the following steps:
[0037] Step 1, preparation of silk protein coating liquid: after the silkworm cocoons are removed from pupae and degummed in turn, they are dissolved; and the obtained solution is dialyzed with deionized water to obtain a regenerated silk protein solution; diluting the regenerated silk protein solution to obtain a volume Silk protein coating liquid with a concentration of 1~8%;
[0038] Step 2, preparation of silk protein-coated polypropylene mesh: place the clean polypropylene mesh in the silk protein coating liquid and fully soak it for 12 to 24 hours, then take it out and dry it; Soak in the protein coating solution, and dry for 4 to 6 times; then place it in an ethanol solution for 20 to 40 minutes, and dry it again to obtain a silk protein coated polypropylene mesh.
[0039] The present invention also includes the application of the silk protein polypropylene mesh...
Embodiment 1
[0042]Step 1: Ultrasonic cleaning and plasma treatment are performed on ordinary polypropylene mesh to prepare clean polypropylene mesh.
[0043] Step 2: Dilute the purchased pure silk protein solution with deionized water to a volume concentration of 4-6% to obtain a regenerated silk protein solution.
[0044] Step 3: Put the clean polypropylene mesh obtained in step 1 into the regenerated silk protein solution obtained in step 2 to fully infiltrate, and apply the regenerated silk protein solution on the surface of the polypropylene mesh; take it out and dry it after 15 hours ; Repeat the regenerated silk protein solution coating process of the above polypropylene mesh five times, then place it in 70% ethanol for 20-40 minutes, and obtain the silk protein coated polypropylene mesh after drying.
Embodiment 2
[0046] Step 1: Ultrasonic cleaning and plasma treatment are performed on ordinary polypropylene mesh to prepare clean polypropylene mesh.
[0047] Step 2: Preparation of silk protein coating solution: Remove cocoons from silkworm cocoons, treat them with 1%~5% sodium bicarbonate at 90-100°C for 30~90 minutes, and then rinse them with deionized water; repeat the above steps to remove chrysalis Wash the silkworm cocoons 1~3 times to completely remove the sericin; after cleaning, dry the silkworm cocoons after taking out the sericin at 65°C for 24 hours to obtain degummed silk, and dry the degummed silk at 30~60°C Dissolve in 7~10mol / L lithium bromide solution to remove undissolved degumming by filtration; after 30~90 minutes, pour the lithium bromide solution of degummed silk into a cellulose dialysis bag with a residual molecular weight of 10000~14000, and use a deionized The regenerated silk protein solution was prepared by water dialysis for 3 days, and the obtained 5% regene...
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