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Ornidazole injection and its preparation method

An ornidazole injection, ornidazole technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve irritation, increase medical risks, and consume large amounts, etc. question

Inactive Publication Date: 2012-02-01
SHANDONG FANGMING PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Domestic existing ornidazole injection is listed, but it adopts propylene glycol to do solvent, and consumption is bigger, and has bigger side effect, and the propylene glycol aqueous solution of any concentration all can cause the whole hemolysis of human erythrocyte, as injection solvent, has certain stimulant effect, increasing the medical risk

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0007] The present invention will be described in detail below in conjunction with examples: ornidazole injection of the present invention and preparation method thereof, is characterized in that ornidazole is added in the water for injection, adjusts pH value with glacial acetic acid, makes stable The ornidazole solution is subpackaged and sterilized to obtain an aqueous injection.

[0008] Example: In a clean room, take an appropriate amount of water for injection (25°C-35°C) into the container, add 100g of ornidazole into the water, stir evenly, add glacial acetic acid until completely dissolved, adjust the pH to 2.5-4.0, add 1g of activated carbon, stir for 15 minutes, filter, add water to 2000ml (the temperature of the liquid medicine is controlled at 25°C to 35°C), filter, fill, sterilize, light check, and pack.

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PUM

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Abstract

The invention relates to a compound pharmaceutical preparation, i.e. an Ornidazole injection and its preparation method. The preparation contains Ornidazole, glacial acetic acid and injection water. The preparation method comprises the steps of: taking a proper amount of injection water (25DEG C-35DEG C), glacial acetic acid and Ornidazole, adding Ornidazole into water and stirring well, adding glacial acetic acid till complete dissolution, adjusting pH to 2.5-4.0, adding activated carbon which is 0.05% (g / ml) of the total volume of the solution, stirring the solution for 15min and conducting filtration, adding water to full capacity (with the temperature of the medical solution controlled between 25DEG C to 35DEG C), then carrying out filtration, embedding, disinfection, light inspection and packaging, thus obtaining the injection. The injection and its preparation method provided in the invention have the characteristics of simple prescription and process, high production efficiency, strong stability of the medical solution, etc.

Description

Technical field: [0001] The invention relates to ornidazole injection and a preparation method thereof, belonging to the technical field of medicines. Background of the invention: [0002] Ornidazole, a nitroimidazole derivative, is a powerful drug against anaerobic bacteria and antiprotozoal infections. The third-generation nitroimidazole derivatives with better sex and wider distribution in the body have been widely used in clinical applications since their listing in the 1970s due to their good anti-anaerobic and anti-biotic (such as trichomonas, etc.) infection effects. Its antimicrobial effect is through the reduction of nitro groups in its molecules to amino groups in an oxygen-free environment or through the formation of free radicals, interacting with cell components, resulting in the death of microorganisms. It can widely treat various diseases caused by anaerobic bacteria, amoeba, giardia, trichomonas and other infections. Studies have found that ornidazole also ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/4164A61K47/12A61P31/04A61P31/10A61P33/02
Inventor 吴双俊范兴山王飞龙付建
Owner SHANDONG FANGMING PHARMACEUTICAL CO LTD
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