High-efficiency crystallization method of trichlorosucrose

A technology for sucralose and crystallization, which is applied in the field of high-efficiency crystallization of sucralose, can solve problems such as affecting product purity, production efficiency and yield, production cost impact, and product quality, and achieves shortened production cycle and low equipment requirements. , to avoid the effect of incomplete crystallization

Inactive Publication Date: 2012-02-01
安徽万和制药有限公司
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Problems solved by technology

[0003] In the production process of sucralose, the crystallization step is very critical, which directly affects the purity, production efficiency and yield of the product, which further affects the production ...

Method used

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  • High-efficiency crystallization method of trichlorosucrose

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Embodiment 1

[0012] Sucralose was crystallized as follows:

[0013] (1) The formation of crystal nuclei: Concentrate the sucralose solution to a sugar content of 72%, put it into a jacket and keep the jacket temperature at 55°C, keep it warm for 1 hour, promote the formation of crystal nuclei, and obtain the trichloride that forms the crystal nuclei. Sucrose solution;

[0014] (2) Growth of crystal nuclei: program cooling of the sucralose solution forming the crystal nuclei, first in the range of 55-50 °C at a rate of 1 °C / 10 min; then in the range of 50-45 °C at a rate of 0.5 Cool at a rate of ℃ / 10min, and keep warm at 45°C for 1 hour; then cool at a rate of 1°C / 6min in the range of 45-35°C, and finally cool down to 25°C with circulating water, centrifuge and dry to obtain crystals.

[0015] In order to illustrate the effect of the crystallization method of the present invention, the direct cooling crystallization method in the prior art is used as comparative example 1 and the natural c...

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Abstract

The invention discloses a high-efficiency crystallization method of trichlorosucrose, belonging to the field of compound treatment. The method comprises the following steps: holding trichlorosucrose solution with a certain of sugar degree within a certain temperature range to promote nucleation, and cooling according to a periodic procedure to promote crystal nucleus to grow quickly, thereby achieving the goal of high-efficiency crystallization. The invention solves the problems of incomplete crystallization, irregular crystal shape and low yield in the trichlorosucrose crystallization process, has the advantages of simple steps and high efficiency, and is very suitable for industrial production.

Description

technical field [0001] The invention relates to a compound processing method, more specifically, a high-efficiency crystallization method for sucralose. Background technique [0002] Sucralose, namely 4,1',6'-trichloro-4,1',6'-trideoxygalactose, is a new type of sweetener, which is to select the 4,1',6' hydroxyl group of sucrose Its sweetness is 600 times that of sucrose. It does not participate in human metabolism. What is particularly interesting is that it has low calories and can completely replace different products (such as food, candy, beverages, The saccharin and sucralose used in cough medicine tablets) have good chemical stability, are not prone to pyrolysis or hydrolysis reactions, especially have good stability in acidic solutions, and are a promising sweetener. [0003] In the production process of sucralose, the crystallization step is very critical, which directly affects the purity, production efficiency and yield of the product, thereby further affecting th...

Claims

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Application Information

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IPC IPC(8): C07H5/02C07H1/06
Inventor 李玠
Owner 安徽万和制药有限公司
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