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Method for preparing faveline and faveline methyl ether simultaneously

A technology for nettle methyl ether and nettle, applied in the field of natural medicine extraction, can solve problems such as undiscovered nettle, and achieve the effects of high product content, simple process, and process environmental protection and safety.

Inactive Publication Date: 2012-03-28
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on a large number of methods for simultaneously preparing nettlestingin and nettlestingin methyl ether

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Dry and pulverize Urtica thorns into a coarse powder, put 2kg into the extraction kettle, and carry out supercritical CO 2 extraction. The extraction conditions are as follows: heat the extraction tank to 45°C and the separation tank to 50°C through a heat exchanger, and cool the CO2 through a refrigeration device. 2 storage tank, open CO 2 Steel cylinder, the flow rate is 15L / h, open the booster pump to raise the pressure of the extraction kettle to 18MPa, the pressure of the separation kettle to 5MPa, close the CO 2 Cylinder valve, open the circulation, add 200ml n-heptane entrainer to the entrainer storage tank, then open the entrainer high-pressure pump valve, so that the entrainer is pumped into the extraction kettle, and after 3 hours of extraction, open the separation kettle to collect the extract. The extract was added to polyamide, stirred evenly, dried at low temperature, packed into a column, and eluted with a mixed solution of n-hexane-acetone in sequence ...

Embodiment 2

[0017] Dry and pulverize Urtica thorns into a coarse powder, put 2kg into the extraction kettle, and carry out supercritical CO 2 extraction. The extraction conditions are as follows: heat the extraction tank to 35°C and the separation tank to 43°C through a heat exchanger, and cool the CO2 through a refrigeration device. 2 storage tank, open CO 2 Steel cylinder, the flow rate is 15L / h, open the booster pump to raise the pressure of the extraction kettle to 26MPa, the pressure of the separation kettle to 7MPa, close the CO 2 Cylinder valve, open the circulation, add 200ml of n-heptane entrainer to the entrainer storage tank, then open the entrainer high-pressure pump valve, so that the entrainer is pumped into the extraction kettle, and after 2 hours of extraction, open the separation kettle to collect the extract. The extract was added to polyamide, stirred evenly, dried at low temperature, packed into a column, and eluted with a mixed solution of n-hexane-acetone in sequen...

Embodiment 3

[0019] Dry and pulverize Urtica thorns into a coarse powder, put 2kg into the extraction kettle, and carry out supercritical CO 2 extraction. The extraction conditions are as follows: heat the extraction tank to 50°C and the separation tank to 60°C through a heat exchanger, and cool the CO2 through a refrigeration device. 2 storage tank, open CO 2 Steel cylinder, the flow rate is 15L / h, open the booster pump to raise the pressure of the extraction kettle to 15MPa, the pressure of the separation kettle to 6MPa, close the CO 2 Cylinder valve, open the circulation, add 200ml n-heptane entrainer to the entrainer storage tank, then open the valve of the entrainer high-pressure pump, so that the entrainer is pumped into the extraction kettle, and after 4 hours of extraction, open the separation kettle to collect the extract. The extract was added to polyamide, stirred evenly, dried at low temperature, packed into a column, and eluted with a mixed solution of n-hexane-acetone in se...

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PUM

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Abstract

The invention belongs to the technical field of the extraction of natural medicaments, and relates to a method for preparing faveline and faveline methyl ether simultaneously. The method comprises the following steps of: (1) drying and crushing medicinal materials, extracting by using supercritical CO2, extracting for 2 to 4 hours by taking n-heptane as an entrainer, resolving extracting solution, and recovering a reagent to obtain an extract; (2) adsorbing the extract by adding a polyamide resin column, eluting n-hexane-acetone mixed solution, collecting eluent, and concentrating under reduced pressure to obtain extractum; and (3) drying the extractum by adding aluminum oxide, loading on a column, eluting cyclohexane-ethyl acetate, collecting eluent, concentrating under reduced pressure, recovering the reagent, and drying at low temperature to obtain the faveline and the faveline methyl ether. By the method, the prepared products have high purity and high quality.

Description

technical field [0001] The invention belongs to the technical field of extraction of natural medicines, and relates to a method for simultaneously preparing nettlesin and nettlesin methyl ether. Background technique [0002] Urtica stingin (Faveline) and urtica stingin methyl ether (Faveline methyl ether) are stinging nettles from Cnidoscolus phyllacanthus (Mart.) Two cycloheptene compounds isolated from the bark of Pax et K. Hoffm. The molecular formula and molecular weight of stingingin are C 18 h 22 o 2 , 270.37; the molecular formula and molecular weight of nettlein methyl ether are C 19 h 24 o 2 , 284.40. Pharmacological studies have shown that the IC of stingin and stingin on P388 mouse leukemia cells in vitro 50 They were 18.6 μg / mL and 1.8 μg / mL respectively, showing that these two compounds have certain cytotoxic activity. At present, there is no report on a large number of methods for simultaneously preparing nettlestingin and nettlestingin methyl ether. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/755C07C45/78
CPCY02P20/54
Inventor 刘东锋郭琴
Owner NANJING ZELANG MEDICAL TECH