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Method for extracting liquiritin from liquorice

A technology of liquiritin and licorice, applied in the field of extraction and purification of liquiritin, can solve the problems of low production efficiency, complicated extraction process, singleness and the like

Inactive Publication Date: 2012-03-28
天津市尖峰天然产物研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Chinese patent CN101289480 is a separation and preparation method of liquiritin through water extraction, alcohol precipitation, membrane separation, and then using macroporous resin to separate liquiritin; Chinese patent CN102050851A liquiritin and its preparation method is to extract liquiritin from glycyrrhizic acid powder. Dilute ammonia water extraction, organic solvent extraction, and then use polyamide resin to separate liquiritin; these patented extraction processes are relatively complicated, and all use a single resin, and the production efficiency is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A method for extracting liquiritin from licorice, comprising the steps of:

[0020] (1) Glycyrrhizae was crushed into 60-mesh powder, extracted with deionized water for 120 minutes at 90°C and the mass ratio of solid to liquid was 1:5, and filtered through four layers of gauze to obtain the crude extract of liquiritin;

[0021] (2) Put the crude extract of liquiritin on the mixed resin column, the mixed resin is composed of polyamide resin 30-60 mesh and macroporous resin HPD-100 with a mass ratio of 2:8, and use 5 times the column volume of deionized water , the volume percentage concentration of 4 times column volume is 20% ethanol water solution, the volume percentage concentration of 4 times column volume is 50% ethanol water solution for elution, and the collection volume percentage concentration is 50% ethanol water solution eluent, decompression Concentrate to a sugar content of 30%, add an equal volume of deionized water, stir well, crystallize at 20°C for 8 hou...

Embodiment 2

[0023] A method for extracting liquiritin from licorice, comprising the steps of:

[0024] (1) Crush the licorice into 60-mesh powder, extract with deionized water for 120 minutes at 90°C and the mass ratio of solid to liquid is 1:7, filter with four layers of gauze, and obtain the crude extract of liquiritin;

[0025] (2) Put the crude extract of liquiritin on the mixed resin column, the mixed resin is composed of polyamide resin 60-100 mesh and macroporous resin D101B with a mass ratio of 2:8, use 6 times the column volume of deionized water, 4 The volume percent concentration of 3 times the column volume is 30% ethanol aqueous solution, and the volume percent concentration of 4 times the column volume is 50% ethanol aqueous solution for elution, and the collected volume percent concentration is 50% ethanol aqueous solution eluent, concentrated under reduced pressure to The sugar content is 30%, add an equal volume of deionized water, stir well, crystallize at 20°C for 8 hou...

Embodiment 3

[0027] A method for extracting liquiritin from licorice, comprising the steps of:

[0028] (1) Glycyrrhizae was crushed into 60-mesh powder, extracted with deionized water for 120 minutes at 90°C and the mass ratio of solid to liquid was 1:8, and filtered through four layers of gauze to obtain the crude extract of liquiritin;

[0029] (2) Put the crude extract of liquiritin on the mixed resin column, the mixed resin is composed of polyamide resin 60-100 mesh and macroporous resin HP-30 with a mass ratio of 2:8, and use 7 times the column volume of deionized water , the volume percent concentration of 4 times the column volume is 40% ethanol aqueous solution, the volume percent concentration of 4 times the column volume is 50% ethanol aqueous solution for elution, and the volume percent concentration of collecting is 50% ethanol aqueous solution eluate, decompression Concentrate to a sugar content of 30%, add an equal volume of deionized water, stir well, crystallize at 20°C fo...

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PUM

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Abstract

The invention discloses a method for extracting liquiritin from liquorice, and the method comprises the following steps: (1) crushing the liquorice, extracting with deionized water and filtering to get liquiritin crude extract solution; and (2) mixing the liquiritin crude extract solution with a resin column, and performing elution, separation, purification and recrystallization. The liquiritin extracted by the method is a natural extract which is high in purity and low in cost, the production efficiency is high and the quality is stable and controllable.

Description

technical field [0001] The invention belongs to a method for extracting and purifying liquiritin, in particular to a method for extracting liquiritin from licorice. Background technique [0002] Licorice is the dried roots and rhizomes of Glycyrrhiza uralensis Fisch., G. inflata Bata1., and G. glabra L. of the leguminous plants Glycyrrhiza uralensis Fisch. Clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasm and relieving pain, and harmonizing the effects of various medicines. The flavonoids in licorice have a variety of biological activities. In addition to anti-inflammatory, antibacterial, and anti-allergic effects, they also have obvious effects on anti-oxidation, anti-cancer, anti-cancer, and anti-tumor. Modern pharmacological studies have shown that liquiritin, isoliquiritin, liquiritigenin and isoliquiritigenin are the main active ingredients of licorice flavonoids. [0003] Liquiritin is an isomer of isoliquiritin, white crystal, mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/26C07H1/08
Inventor 吴巍
Owner 天津市尖峰天然产物研究开发有限公司
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