Diagnostic reagent for serum of early breast cancer and detection method thereof

A diagnostic reagent and early diagnosis technology, applied in the biological field, can solve problems such as unsatisfactory tumor markers

Inactive Publication Date: 2012-03-28
SHAOXING PEOPLES HOSPITAL
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Problems solved by technology

[0017] The purpose of the present invention is to overcome the unsatisfactory problem of the existing tumor markers of breast cancer, to improve the sensitivity, specificity and accuracy of early diagnosis of breast cancer, and to prepare a stable diagnostic marker by using a specific and sensitive diagnostic marker. It is a diagnostic reagent for early diagnosis of breast cancer or postoperative efficacy monitoring with good sex and convenient detection

Method used

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  • Diagnostic reagent for serum of early breast cancer and detection method thereof
  • Diagnostic reagent for serum of early breast cancer and detection method thereof
  • Diagnostic reagent for serum of early breast cancer and detection method thereof

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Embodiment Construction

[0062] 1. Sources of specimens, reagent consumables and main instruments used in the present invention

[0063] 1. The source of the specimen

[0064] With the consent of myself and my family members, a total of 40 cases of breast cancer fresh tissues were obtained from patients who underwent breast and thyroid surgery in the hospital from May 2009 to May 2010. The lesions and paracancerous tissues were removed and quickly transferred to liquid nitrogen tanks , -80 ℃ ultra-low temperature refrigerator for future use; a total of 273 breast cancer patient serum samples were grouped according to clinical stage, pathological type and metastasis; at the same time, serum samples of 54 normal women and 40 female patients with other tumors were taken as the control group , and stored in a -80°C ultra-low temperature refrigerator for later use. The specific clinical data are shown in Table 1.

[0065]

[0066] project breast cancer other cancers normal control gr...

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Abstract

The invention discloses a diagnostic reagent for serum of early breast cancer and a detection method thereof. A ferritin heavy chain 1 (FTH1) or an FTH1 united heterogeneous nuclear ribonucleoprotein F (hnRNPF) is adopted by the diagnostic reagent to serve as a tumor marker, thus, the diagnostic reagent is capable of detecting an FTH1 antibody in the serum to be detected, or the corresponding antibody of the FTH1 and the hnRNPF, and is used for early diagnosis of the breast cancer or postoperative curative effect monitoring. The reagent disclosed by the invention is verified through the application of the serum of patients with the breast cancer, breast benign tumor and other kinds of cancer (not including the breast cancer) and normal people. The diagnostic reagent for the serum of the early breast cancer is used for the early diagnosis and differential diagnosis of the breast cancer, aims to improve the sensitivity, the specificity and the accuracy of the early diagnosis of the breast cancer and is more beneficial to the diagnosis and the treatment of the patients with the breast cancer, thereby, the problem that the traditional tumor marker of the breast cancer is not ideal is solved, and the goal of improving the sensitivity and the accuracy of the early diagnosis of the breast cancer is achieved.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a serum diagnostic reagent for early breast cancer and a detection method thereof. Background technique [0002] Breast cancer is the most common malignancy in women. Studies have shown that the incidence of breast cancer accounts for 31% of gynecological tumors, and the mortality rate ranks second among tumors. In recent years, the incidence of breast cancer has been on the rise, and it has become the primary malignant tumor that threatens the health of women in my country. Although there are no special preventive measures for breast cancer at present, it is a tumor that is easy to treat and control at an early stage. If it can be detected, diagnosed and treated early, the prognosis is generally better. Clinically, some breast cancers have achieved ideal therapeutic effects due to early detection, but most patients have missed the best opportunity for treatment due to late detectio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
Inventor 董学君李志国
Owner SHAOXING PEOPLES HOSPITAL
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