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Transdermal administered gel ointment containing rhizoma ligustici wallichii and nutgrass galingale rhizome

A gel ointment and drug delivery technology, applied in the field of pharmaceutical preparations, can solve the problems of high dosage, poor appearance, over-viscosity or poor adhesion, etc., achieve high bioavailability, uniform transdermal rate, and facilitate transdermal absorption Effect

Inactive Publication Date: 2012-04-11
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the two, the onset of oral administration is slow, but the increase in pain is large and lasting
[0012] Since the early 1980s, a large number of Chinese medicine cataplasms have been studied in China. There are a large number of related patents and literature reports, but there are few products on the market, especially the traditional Chinese medicine cataplasm In terms of new product development and market share, the agent is still far from forming a scale. Compared with foreign products, the marketed products are seriously behind. There are mainly the following two problems: 1. Poor appearance and poor application comfort (too sticky or poor adhesion) 2. Low formability (it is easy to become thin when the temperature is high or high humidity, the matrix is ​​easy to deform and flow or the skin has residue); 3. The active ingredients in the traditional Chinese medicine compound are mutually restricted and balanced, and they work together to form It is not possible to ensure that each active ingredient has transdermal permeability after cataplasm
The root causes of these problems mainly lie in: the vast majority of domestic products are non-cross-linked products, and the paste strength (formability) is poor; Large differences in properties; and unreasonable prescription design, etc.

Method used

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  • Transdermal administered gel ointment containing rhizoma ligustici wallichii and nutgrass galingale rhizome
  • Transdermal administered gel ointment containing rhizoma ligustici wallichii and nutgrass galingale rhizome
  • Transdermal administered gel ointment containing rhizoma ligustici wallichii and nutgrass galingale rhizome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 ： Xiongfu gel ointment

[0036] Prepare the gel ointment that contains Rhizoma Chuanxiong and Cyperus Cyperi according to the following prescriptions and processes:

[0037] Chuanxiong hydroalcoholic extract 3 parts Cyperus hydroalcoholic extract 3 parts Polyvinyl acid 1.25 parts 5 parts of β-cyclodextrin Glycerin 12.5 parts 1.2 parts of gelatin Disodium edetate 0.2 parts Sodium tartrate 0.4 parts 0.4 parts of polyvinylpyrrolidone Ethylparaben 0.1 parts Aluminum glycylate 0.1 part Add purified water to 50 parts

[0038] The preparation process is as follows:

[0039] 1. Preparation of Phase A: Mix the extracts of Ligusticum chuanxiong and Rhizoma Cyperi with β-cyclodextrin according to the above ratio, and grind them evenly.

[0040] 2. Preparation of Phase B: Mix the partially neutralized polyacrylic acid NP600, sodium citrate and glycerin according to the above ratio evenly.

[0041] 3. Preparation of ...

Embodiment 2

[0045] Example 2 ： Xiongfu gel ointment

[0046] Prepare the gel ointment that contains Rhizoma Chuanxiong and Cyperus Cyperi according to the following prescriptions and processes:

[0047] Chuanxiong Supercritical CO 2 Extract 2 parts Cyperus supercritical CO 2 Extract 2 parts Polyvinyl acid 1.25 parts 5 parts of β-cyclodextrin Glycerin 12.5 parts 1.2 parts of gelatin Disodium edetate 0.2 parts Sodium citrate 0.2 parts 0.4 parts of polyvinylpyrrolidone Ethylparaben 0.1 parts Aluminum hydroxide 0.1 part 24 parts of purified water

[0048] The preparation process is as in Example 1.

Embodiment 3

[0049] Example 3 ： Xiongfu gel ointment

[0050] Prepare the gel ointment that contains Rhizoma Chuanxiong and Cyperus Cyperi according to the following prescriptions and processes:

[0051] Chuanxiong steam distillate 3 parts Cyperus steam distillate 3 parts Polyvinyl acid 1.5 parts 5 parts of β-cyclodextrin Glycerin 12.5 parts 1.2 parts of gelatin Disodium edetate 0.2 parts Sodium citrate 0.25 parts 0.4 parts of polyvinylpyrrolidone Ethylparaben 0.1 parts Aluminum glycylate 0.15 parts 22 parts of purified water

[0052] The preparation process is as in Example 1.

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Abstract

The invention provides gel ointment which is prepared from extract containing rhizoma ligustici wallichii and nutgrass galingale rhizome as an active ingredient and proper pharmaceutical necessities. The gel ointment is composed of a back lining layer, medicine-containing ointment and a release layer, wherein the medicine-containing ointment is prepared from extract of rhizoma ligustici wallichii and nutgrass galingale rhizome or refined product thereof, a thickening agent, a filling agent, a transdermal permeation accelerator, a humectant and other pharmaceutical necessities according to a certain ratio. The gel ointment can be transdermally administered, and is used for treating and alleviating migraine, gynecological pains and other syndromes.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a transdermal gel ointment containing two traditional Chinese medicines of Rhizoma Chuanxiong and Cyperus cyperi and a preparation method thereof. The gel ointment can be administered through the skin and is used for treating and relieving migraine, migraine, Gynecological pain and other symptoms. Background technique [0002] Pain such as migraine and gynecological pain are common diseases, and there are many methods of treating pain in traditional Chinese medicine, such as dispelling blood stasis, promoting qi, regulating phlegm, regulating blood, and regulating deficiency. [0003] Cyperus Cyperus is a Cyperaceae plant sedge ( Cyperus rotundus L. ) dry rhizome, has the effects of regulating qi and relieving depression, regulating menstruation and relieving pain. It is used for liver stagnation and qi stagnation, chest, flank, and abdominal pain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61K9/06A61K9/70A61K47/32A61K47/36A61K47/38A61K47/42A61P25/06A61P29/02
Inventor 徐晖王小芳唐星徐静华郭建博
Owner SHENYANG PHARMA UNIVERSITY
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