Pharyngitis chewable tablets and molding process thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A molding process and chewable tablet technology, applied in the field of tablets, can solve the problems of low dosage form stability and bioavailability, unfavorable patient absorption, poor stability, etc., and achieve increased stability and bioavailability, good taste and stability, The effect of high absorption rate
Active Publication Date: 2012-04-11
FOURTH MILITARY MEDICAL UNIVERSITY
View PDF6 Cites 9 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0002] Pharyngitis extract has existing dosage forms, such as granules, which are difficult to take, poor stability, inconvenient to carry and low bioavailability, which largely affects the use of patients
The existing pharyngitis chewable tablets have low bactericidal efficiency, and it is directly processed from raw traditional Chinese medicine, the dosage form stability and bioavailability are low, and it is not conducive to patient absorption
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0022] The chewable tablet molding process that increases the stability and bioavailability of the Pharyngitis extract, the formula of the Pharyngitis chewable tablet is composed of the following raw materials in the following weight percentages: 50% Pharyngitis powder as the main drug, 35% mannitol as the filler Agent, 11% lactose, 1% citric acid, 0.2% orange flavor and 0.8% aspartame as flavoring agent, 1% talcum powder, 1% magnesium stearate as glidant, Composition with 10% PVP95% ethanol liquid as binder; Described PVP95% ethanol liquid is the ethanol solution containing povidone K30;
[0023] The specific process of the pharyngitis chewable tablet is as follows:
[0024] 1) extract pharyngitis powder;
[0025] The pharyngitis powder is prepared from honeysuckle, chrysanthemum, platycodon grandiflorum, rehmannia glutinosa, scrophulariaceae, Radix Ophiopogon japonicus, Shegan and licorice in a weight ratio of 3:3:2:2:2:2:2:1; Recipe amount of honeysuckle and chrysanthemum...
Embodiment 2
[0031] Pharyngitis chewable tablet concrete process of the present invention is as follows: the talcum powder of 12g, the magnesium stearate of 12g are as glidant, with the PVP95% ethanol liquid of 120g as binding agent composition;
[0032] 1) extract pharyngitis powder;
[0033] According to the weight ratio of 3: 3: 2: 2: 2: 2: 2: 1, the eight traditional Chinese medicine raw materials of honeysuckle, chrysanthemum, platycodon, rehmannia glutinosa, scrophulariae, Radix Ophiopogon japonicus, Shegan, and licorice were weighed in sequence (that is, 3 parts of honeysuckle , 3 parts of chrysanthemum, 2 parts of bellflower, 2 parts of raw rehmannia, 2 parts of crocodile, 2 parts of Ophiopogon japonicus, 2 parts of shegan, 1 part of licorice) washed and dried for later use;
[0034] Preparation of pharyngitis volatile oil: The honeysuckle and chrysanthemum raw materials measured according to the above formula were added to the supercritical extraction device for CO 2 Supercriti...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to pharyngitis chewable tablets and a molding process thereof. The formula of the pharyngitis chewable tablets is composed of the following raw medicines in percent by weight: 50% of pharyngitis powder, 35% of mannitol, 11% of lactose, 1% of citric acid, 0.2% of orange essence, 0.8% of aspartame, 1% of talcum powder, 1% of magnesium stearate and 10% of PVP(povidone)95% ethanol solution, wherein the PVP95% ethanol solution is a povidone K30-containing ethanol solution. The molding process comprises the following steps of: (1) taking the pharyngitis powder; (2) uniformly mixing the pharyngitis powder with the formulated amounts of mannitol and lactose and a flavoring agent; (3) preparing the PVP95% ethanol solution; and (4) spraying the mixture obtained in the step (2) with 10% of PVP95% ethanol solution in percent by weight to prepare a soft material, then granulating by a 20-mesh sieve, drying at 70 DEG C, then finishing granules by the 20-mesh sieve, adding the formulated amounts of magnesium stearate and talcum powder, spraying the granules with the volatile oil obtained by supercritical extraction in the step (1), and tabletting. The pharyngitis chewable tablets have a good bactericidal effect, good taste, good stability and high absorptivity.
Description
technical field [0001] The invention relates to a tablet, in particular to a pharyngitis chewable tablet and its molding process. Specifically, it provides a chewable tablet molding process with good bactericidal effect, which can increase the stability and bioavailability of pharyngitis extract. Background technique [0002] The pharyngitis extract has dosage forms, such as granules, which are difficult to take, poor stability, inconvenient to carry and low bioavailability, which largely affects the use of patients. The existing pharyngitis chewable tablet has low bactericidal efficiency, and it is directly processed from raw materials of traditional Chinese medicine, the dosage form stability and bioavailability are low, and it is also unfavorable for patients to absorb. Contents of the invention [0003] The purpose of the present invention is to provide a pharyngitis chewable tablet and its molding process, which has good bactericidal effect, good taste and stability, ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more