P-chlorobenzotrifluoride clean nitration reaction catalyzed by heteropoly acid ionic liquid

Abstract

The invention discloses a novel method for carrying out p-chlorobenzotrifluoride clean nitration reaction catalyzed by a heteropoly acid ionic liquid. The used catalyst is an ionic liquid having a heteropoly acid anionic structure, and p-chlorobenzotrifluoride and nitric acid used as raw materials are subjected to nitration reaction under the action of the catalyst, thus obtaining 4-chloro-3-nitrobenzotrifluoride. Compared with the prior art, the invention has the following advantages: (1) the used ionic liquid having a heteropoly acid anionic structure has a wide source of raw materials and is convenient to prepare; and the catalyst is stable in water, can not be inactivated and can be used circularly; (2) compared with corresponding inorganic acid, the heteropoly acid forming the anionic structure has higher strength, higher catalytic activity, less consumption and better environment friendliness; and (3) by using the ionic liquid instead of concentrated sulfuric acid, the nitration process is environment-friendly and has industrial application prospects.

Description

a technical field [0001] The invention relates to a new method for catalyzing the clean nitration reaction of p-chlorobenzotrifluoride by a heteropolyacid ionic liquid, and belongs to the technical field of chemical material preparation. The method is applicable to the occasion of synthesizing 4-chloro-3-nitrobenzotrifluoride with p-chlorobenzotrifluoride and nitric acid as raw materials by heating and stirring under normal pressure. Two background technology [0002] Nitrification is an important unit reaction of organic synthesis, and substituted aromatic nitrates are a very important class of chemical products. The methods and processes of nitration of aromatic compounds have been studied in both academia and industry. Energy saving and emission reduction is an important issue faced by human beings, and the clean nitrification of aromatic compounds has become one of the hotspots of people's research. [0003] The nitrated product of p-chlorobenzotrifluoride, 4-chloro-3-n...

AI Technical Summary

Problems solved by technology

Due to the high cost of imidazole-type ionic liquids, it is not conducive to large-scale application

In addition, a series of studies have shown (Garcia M T, Gathergood N, Scammells P J. Biodegradable ionic liquids Part II. Effect of the anion and toxicology. Green Chem. 2005, 7: 9-14), based on imidazole, pyridinium cation type The biodegradability of ionic liquid is very poor, and it is not easy to degrade through the most widely used biological treatment process or biological self-purification, which has potential harm to the environment. The use of acetic anhydride and trifluoroacetic anhydride is not only costly, but also difficult to obtain from the product. It is not easy to recycle and reuse, which increases the difficulty of post-processing and product separation, and cannot meet the double benefits of environment and economy.

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