Sugar-free erigeron breviscapus mixture and preparation method thereof

A technology of Dengzhan Asarum and Xin mixture, which is applied in the directions of anti-inflammatory agents, pharmaceutical formulations, drug combinations, etc., can solve the problems of diabetes without clinical value, etc., and achieve the effect of safe use and stable quality.

Inactive Publication Date: 2012-05-02
昆明振华制药厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the increase in the proportion of patients with cardiovascular and cerebrovascular diseases complicated by diabetes, the original Erigeron breviscapus mixture mainly uses sucrose as the flavoring agent. For these patients, the intake of sucrose during medication has no clinical value for the control of diabetes. Doctors call for new sugar-free drugs

Method used

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  • Sugar-free erigeron breviscapus mixture and preparation method thereof
  • Sugar-free erigeron breviscapus mixture and preparation method thereof
  • Sugar-free erigeron breviscapus mixture and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The weight ratio of the drug raw materials of the sugar-free breviscapine mixture is:

[0052] Erigeron breviscapitalis extract in terms of total flavonoids 7g

[0053] Ethylparaben 0.2g

[0054] Sodium Benzoate 3g

[0055] Stevia 0.5g

[0056] Xylitol 70g

[0057] 10% sodium hydroxide appropriate amount (adjust the pH value to 7-8)

[0058] Add purified water to 1000ml

[0059] Preparation:

[0060] 1. Preparation of Erigeron breviscapus extract: take escutellaria breviscapus, reflux twice with 80% ethanol, add 10 times the amount of ethanol for the first time to reflux for 1.5 hours, add 6 times the amount of ethanol for the second time to reflux for 1 hours, combined the above two extracts, added 2% activated carbon, heated and boiled for 15 minutes, let stand for 12-72 hours, took the supernatant and concentrated it under reduced pressure to a ratio of 1:1 to the crude drug amount, added 0.5% activated carbon, Heat and boil for 15 minutes, cool to room temperat...

Embodiment 2

[0067] The weight ratio of the drug raw materials of the sugar-free breviscapine mixture is:

[0068] Erigeron breviscapitalis extract in terms of total flavonoids 10g

[0069] Ethylparaben 0.1g

[0070] Sodium Benzoate 2g

[0071] Stevia 0.1g

[0072] Xylitol 40g

[0073] 10% sodium hydroxide appropriate amount (adjust the pH value to 7-8)

[0074] Add purified water to 1000ml

[0075] The preparation method is the same as in Example 1.

Embodiment 3

[0077] The weight ratio of the drug raw materials of the sugar-free breviscapine mixture is:

[0078] Erigeron breviscapitalis extract in terms of total flavonoids 6g

[0079] Ethylparaben 0.3g

[0080] Sodium Benzoate 5g

[0081] Stevia 1g

[0082] Xylitol 100g

[0083] 10% sodium hydroxide appropriate amount (adjust the pH value to 7-8)

[0084] Add purified water to 1000ml

[0085] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a sugar-free erigeron breviscapus mixture and a preparation method thereof. The sugar-free erigeron breviscapus mixture consists of the following medicinal raw materials by weight: 6-10 grams of erigeron breviscapus extracting solution (counted by general flavone), 0.1-0.3 grams of hydroxyphenyl ethylester, 2-5 grams of sodium benzoate, 0.1-1 gram of steviosin and 40-100 grams of xylitol. The sugar-free erigeron breviscapus mixture is suitable for treating hemiplegy, rheumatalgia and angina pectoris caused by blood stasis syndrome cerebral infarction as well as ocular fundus retinal vein occlusion and vasculitis skin diseases; is safe, easy and convenient for using; has stable quality; and can be taken by patients suffering from diabetics.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a sugar-free scutellaria herba mixture and a preparation method thereof. Background technique [0002] Erigeron breviscaqus (Vant.) Hand.-Mazz. is the whole herb of the genus Erigeron breviscaqus (Vant.) Hand.-Mazz. in the family Compositae. In the 1970s, it was clinically verified that it has good curative effect on hypertension, cerebral hemorrhage, cerebral thrombosis, multiple neuritis of cerebral embolism, chronic auricularitis and its sequelae, and also has certain curative effect on rheumatism and coronary heart disease. Our company's "Scutellaria breviscapus mixture and oral liquid" is another new drug developed by using breviscapine asarum, a characteristic resource in Yunnan, after breviscapine injection. It has been favored by many patients since its development and came out. In recent years, as the proportion of patients with cardiovascular and cerebrovascular disea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K47/26A61K9/00A61P9/10A61P25/02A61P29/00A61P17/00A61P9/00
Inventor 李俊
Owner 昆明振华制药厂有限公司
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