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PCL (Polycaprolactone)-Tween 80 copolymer as well as preparation method and application thereof

A polymer and reaction technology, applied in medical science, prosthesis, surgery, etc., can solve problems such as insecurity and human health impact, and achieve simple process, no pollution in the preparation process, good biocompatibility and biological The effect of degradability

Active Publication Date: 2014-04-02
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there are strict restrictions on the use of Tween 80, which is a potentially unsafe excipient, and the use of high concentrations of Tween 80 will have a great impact on human health

Method used

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  • PCL (Polycaprolactone)-Tween 80 copolymer as well as preparation method and application thereof
  • PCL (Polycaprolactone)-Tween 80 copolymer as well as preparation method and application thereof
  • PCL (Polycaprolactone)-Tween 80 copolymer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1, preparation PCL-Tween80 copolymer

[0036] Accurately weigh 9g (90% of the total monomer mass) of caprolactone monomer and 1g (10% of the total monomer mass) of Tween 80 as raw materials, and take 0.1% of the total monomer mass of the catalyst stannous octoate and add it to the polymerization tube , carry out vacuum degassing and nitrogen replacement process, repeat three times (to ensure the anaerobic condition of the equipment), seal the polymerization tube, and carry out the ring-opening polymerization reaction under heating in an oil bath at 160°C. After 16 hours of polymerization, the product was cooled and dissolved in methylene chloride, and excess methanol was added to precipitate the copolymer. Methanol unreacted monomer and Tween 80 were removed by filtration. The resulting precipitate was vacuum-dried at 45°C for 48 hours to obtain the PCL-Tween80 copolymer provided by the present invention.

[0037] The results of Fourier transform infrared s...

Embodiment 2

[0042] Embodiment 2, preparation PCL-Tween 80 copolymer

[0043] Accurately weigh 6g (monomer total mass 60%) caprolactone monomer and 4g (monomer total mass 40%) Tween 80 as raw materials, take 0.1% catalyst stannous octoate of monomer total mass and add in the polymerization tube , carry out the vacuum degassing and nitrogen replacement process, repeat three times (to ensure the anaerobic condition of the equipment), seal the polymerization tube, and carry out the ring-opening polymerization reaction under heating in an oil bath at 140°C. After 12 hours of polymerization, the product was cooled and dissolved in methylene chloride, and excess methanol was added to precipitate the copolymer. Methanol unreacted monomer and Tween 80 were removed by filtration. Vacuum dry the resulting precipitate at 45°C for 48 hours to obtain a PCL-Tween 80 copolymer with a molecular weight of 1000. In formula I, x is an integer of 2-14, y is an integer of 2-14, and z is an integer of 2-14 , ...

Embodiment 3

[0044] Embodiment 3, preparation PCL-Tween 80 copolymer

[0045] Accurately weigh 9.9g (monomer total mass 99%) caprolactone monomer and 0.1g (monomer total mass 1%) Tween 80 as raw material, get 0.1% catalyst stannous octoate of monomer raw material gross mass and add polymerization In the tube, the process of vacuum degassing and nitrogen replacement was carried out three times (to ensure the anaerobic condition of the equipment), the polymerization tube was sealed, and the ring-opening polymerization reaction was carried out under heating in an oil bath at 160°C. After 16 hours of polymerization, the product was cooled and dissolved in methylene chloride, and excess methanol was added to precipitate the copolymer. Methanol unreacted monomer and Tween 80 were removed by filtration. The resulting precipitate was vacuum-dried at 45°C for 48 hours to obtain a PCL-Tween 80 copolymer with a molecular weight of 43,000. 17, wherein, w+x+y+z=20, l is 2-365, m is 2-365, n is 2-365,...

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Abstract

The invention discloses a biodegradable PCL (Polycaprolactone)-Tween 80 copolymer as well as a preparation method and application thereof. The copolymer has a structure general formula shown in a formula I described in the specification. The preparation method of the copolymer comprises the steps of: uniformly mixing caprolactone and Tween 80, and carrying out ring-opening polymerization reaction to obtain the polymer shown in the formula I after the reaction is finished. The method for preparing the PCL-Tween 80 copolymer, disclosed by the invention, has a simple process and no pollution in the preparation process; and the obtained copolymer has good biocompatibility and biodegradability, is a promising material and has an important application value.

Description

technical field [0001] The invention relates to a PCL-Tween 80 copolymer and its preparation method and application. Background technique [0002] Preparations need to be innovated, and excipients should go first. Pharmaceutical excipients are the basic materials and important components of pharmaceutical preparations, the material basis to ensure the production and development of pharmaceutical preparations, and play a key role in the formulation and production of pharmaceutical preparations. Without good excipients, there will be no good preparations, and without good preparations, there will be no good medicines. The rational application of a new excipient can correspond to a large class of dosage forms and a large number of new preparation products, and can make the quality of a batch of products meet the standards of international products. The economic and social benefits it brings cannot be estimated. [0003] Polyε-caprolactone (PCL, Polycaprolactone) is a pharmace...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/664C08G63/78C08G63/90A61K47/34A61K31/337A61K31/428A61L17/10A61L27/18A61L31/06
Inventor 梅林黄来强郑义
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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