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Resveratrol and bioflavonoid composition as well as preparation and application thereof

A technology of bioflavonoids and resveratrol, which is applied in the field of pharmaceuticals, can solve problems such as increasing the solubility angle or inhibiting metabolic enzymes, so as to achieve the effects of improving bioavailability, reducing drug dosage, and increasing drug efficacy

Inactive Publication Date: 2012-05-16
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN101292966A A solid dispersion of resveratrol and glycosides and its preparation method, although the solubility of resveratrol is improved, it is still rapidly metabolized by two-phase enzymes after absorption in the body
Although some of the above documents or patents involve methods for improving the bioavailability of resveratrol, they all have certain limitations from the perspective of improving solubility or inhibiting metabolic enzymes.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The composition of resveratrol solid dispersion and bioflavonoid solid dispersion of the present invention is made up of following raw material by weight ratio:

[0028] Resveratrol solid dispersion: curcumin solid dispersion = 1:2

[0029] Resveratrol: PVP=1:4, curcumin: PVP=1:4.

[0030] Take resveratrol, PVP, curcumin and PVP according to the above ratio, dissolve them with appropriate amount of ethanol, spray dry them at 80°C respectively, pass through a 40-mesh sieve according to the above ratio, and mix to obtain the finished product.

Embodiment 2

[0032] The composition of resveratrol solid dispersion and bioflavonoid solid dispersion of the present invention is made up of following raw material by weight ratio:

[0033] Resveratrol solid dispersion: curcumin solid dispersion = 1:4,

[0034] Resveratrol: PEG6000=1:5, curcumin: PEG6000=1:5.

[0035] Take resveratrol, PEG6000, curcumin and PEG6000 according to the above proportions, melt them in a water bath at 75°C respectively, pour them into a stainless steel plate while they are hot and solidify at -70°C, crush them, dry them in vacuum, and mix them according to the above proportions to obtain the finished product.

Embodiment 3

[0037] The composition of resveratrol solid dispersion and bioflavonoid solid dispersion of the present invention is made up of following raw material by weight ratio:

[0038] Resveratrol solid dispersion: Curcumin solid dispersion: Quercetin solid dispersion=1:3:3,

[0039] Resveratrol: PEG6000=1:6, curcumin: PEG6000=1:6, quercetin: PEG6000=1:6.

[0040] Take resveratrol and PEG6000, curcumin and PEG6000, quercetin and PEG6000 according to the above proportions, melt them in a water bath at 80°C respectively, pour them into a stainless steel plate while they are hot and solidify at -70°C, grind them and dry them in a vacuum, and dry them as described above The ratio is sieved and mixed to obtain the finished product.

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PUM

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Abstract

The invention relates to a resveratrol and bioflavonoid composition as well as preparation and application thereof. The active ingredients of the resveratrol and bioflavonoid composition comprise resveratrol solid dispersion and bioflavonoid solid dispersion in a weight ratio of (1-10):(1-10). The resveratrol and bioflavonoid composition provided by the invention has the advantages and effects that: in the composition, the resveratrol solid dispersion can improve the water solubility of resveratrol; and at the same time, after the bioflavonoid and resveratrol are combined, the metabolizing enzymes for glucuronidation and sulfonation of resveratrol are inhibited, thus the metabolism of resveratrol is inhibited and the bioavailability of resveratrol is improved.

Description

technical field [0001] The invention relates to a composition of resveratrol solid dispersion and bioflavonoid solid dispersion and its preparation and application, belonging to the fields of medicine and health products. Background technique [0002] The phenomenon of "French Paradox" makes people realize that resveratrol, the French people have a high smoking rate and high intake of animal fat, but the mortality rate caused by cardiovascular disease is particularly low, because the French drink more resveratrol. Red wine, which contains resveratrol, has a certain effect on the prevention and treatment of cardiovascular diseases. In addition, resveratrol also has a wide range of pharmacological effects such as anti-tumor, anti-cardiovascular disease, anti-inflammation, anti-oxidation and anti-free radicals. However, because it is insoluble in water, although it can be well absorbed in the body, its bioavailability is almost zero, which greatly limits its clinical applicati...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K31/05A61K31/352A61K9/14A61P35/00A61P9/00A61P29/00A61P39/00A61P39/06A23L1/29A23L33/00
Inventor 马小军王丽岩吕国军赵姗于炜婷
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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