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Anti-Acinetobacter baumannii drug combination and application thereof

A technology of Acinetobacter baumannii and composition, applied in the field of pharmaceutical composition, capable of solving problems such as limited activity

Inactive Publication Date: 2012-05-30
LIVZON PHARM GRP INC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results of several in vitro studies have shown that the combination of sulbactam with cefepime, amikacin, rifampicin and other antibiotics can enhance the antibacterial activity against Acinetobacter baumannii, but the activity is still very limited

Method used

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  • Anti-Acinetobacter baumannii drug combination and application thereof
  • Anti-Acinetobacter baumannii drug combination and application thereof
  • Anti-Acinetobacter baumannii drug combination and application thereof

Examples

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Embodiment 1

[0019] 1. Materials

[0020] (1) Experimental strains: 40 meropenem-resistant and 41 meropenem-sensitive strains were randomly selected from preserved Acinetobacter baumannii (collected in 19 hospitals in China, time: January 2005 to September 2009). All Acinetobacter baumannii were re-identified as calcium acetate-Acinetobacter baumannii complex by VITEK GNI of BioMérieux, and then identified by 16S-23S rRNA sequence sequencing. The quality control strain was ATCC25922.

[0021] (2) Main reagents and instruments: Meropenem (Shenzhen Haibin Pharmaceutical Co., Ltd., batch number: 20090903. Calculated as anhydrous matter, actual content: 87.0%); sulbactam (Shenzhen Haibin Pharmaceutical Co., Ltd., batch number: 0030009072. Based on anhydrous matter, the actual content: 89.3%). Colistin E, ampicillin / sulbactam, piperacillin / tazobactam, and Etest strips of three kinds of antibacterial drugs are products of AB Biodisk, Sweden. OXOID discs are used for cefepime, ceftazidime, pip...

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Abstract

The invention provides an anti-Acinetobacter baumannii drug combination and an application thereof. The drug combination contains meropenem and sulbactam with the weight ratio of meropenem to sulbactam being 1:2-4. The invention is designed by a checkerboard method. The synergetic antibacterial effect of the combined use of meropenem and sulbactam to carbapenems sensitive and drug resistant Acinetobacter baumannii is found by broth microdilution detection. As shown in the test result, no matter meropenem drug resistant strain or meropenem sensitive strains, most of them show a synergetic and partly synergetic effect to the combined use of meropenem and sulbactam and the strains which show a synergetic effect account for 25%.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its application, in particular to an anti-Acinetobacter baumannii pharmaceutical composition and its application. Background technique [0002] Acinetobacter baumannii is an important pathogen that causes nosocomial infections, and the treatment of multidrug-resistant Acinetobacter baumannii infection has become a major clinical problem. Anti-pseudomonal carbapenem antibiotics, such as imipenem and meropenem, are the most important drugs for the treatment of multidrug-resistant Acinetobacter baumannii infection. However, it has been reported that carbapenem-resistant Acinetobacter baumannii (CRAB) has spread widely around the world, causing serious public health problems. However, there are very limited clinical options for the treatment of CRAB antibiotics, and the antibacterial activity of newly developed antibacterial drugs against this type of drug-resistant Acinetobacter baumannii is not i...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K31/407A61P31/04A61P11/00A61P7/00A61P13/02A61P17/02
Inventor 胡海棠高朗王蕾王云华俞云松陈衍
Owner LIVZON PHARM GRP INC
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