Anti-Acinetobacter baumannii drug combination and application thereof

A technology of Acinetobacter baumannii and composition, applied in the field of pharmaceutical composition, capable of solving problems such as limited activity
CN102475703AInactive Publication Date: 2012-05-30LIVZON PHARM GRP INC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
LIVZON PHARM GRP INC
Publication Date
2012-05-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides an anti-Acinetobacter baumannii drug combination and an application thereof. The drug combination contains meropenem and sulbactam with the weight ratio of meropenem to sulbactam being 1:2-4. The invention is designed by a checkerboard method. The synergetic antibacterial effect of the combined use of meropenem and sulbactam to carbapenems sensitive and drug resistant Acinetobacter baumannii is found by broth microdilution detection. As shown in the test result, no matter meropenem drug resistant strain or meropenem sensitive strains, most of them show a synergetic and partly synergetic effect to the combined use of meropenem and sulbactam and the strains which show a synergetic effect account for 25%.
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Description

technical field

[0001] The invention relates to a pharmaceutical composition and its application, in particular to an anti-Acinetobacter baumannii pharmaceutical composition and its application. Background technique

[0002] Acinetobacter baumannii is an important pathogen that causes nosocomial infections, and the treatment of multidrug-resistant Acinetobacter baumannii infection has become a major clinical problem. Anti-pseudomonal carbapenem antibiotics, such as imipenem and meropenem, are the most important drugs for the treatment of multidrug-resistant Acinetobacter baumannii infection. However, it has been reported that carbapenem-resistant Acinetobacter baumannii (CRAB) has spread widely around the world, causing serious public health problems. However, there are very limited clinical options for the treatment of CRAB antibiotics, and the antibacterial activity of newly developed antibacterial drugs against this type of drug-resistant Acinetobacter baumannii is not i...

Claims

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