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Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation

A compound preparation and technology for chronic renal failure, applied in the field of oral preparations of traditional Chinese medicine, can solve the problems of large input of astragalus, no ratio relationship, and influence of astragalus on drug efficacy

Active Publication Date: 2012-05-30
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The original patent 200410039418.X discloses a kind of Shenkang suppository and its preparation method. Its prescription protects the scope of use of traditional Chinese medicine, and there is no specific ratio relationship. Although the case of the prescription is also disclosed in the patent document embodiment, but The amount of astragalus is relatively large, and there is a precipitation reaction between astragalus and rhubarb, and there is also a reaction between astragalus and salvia miltiorrhiza, and the small amount of astragalus in the preparation also affects the efficacy

Method used

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  • Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation
  • Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation
  • Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation

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Effect test

Embodiment 1

[0097] The Shenkang oral solid compound preparation of the present invention is prepared from the following raw materials in the proportions: 1500g of rhubarb, 1500g of salvia, 4500g of astragalus, and 1500g of safflower. The preparation method is as follows: after the raw material drugs rhubarb and salvia miltiorrhiza are extracted according to the above formula ratio, first alcohol precipitation, detanning, second alcohol precipitation, water precipitation, third alcohol precipitation, and second water precipitation; then astragalus , Safflower is extracted according to the above formula ratio, once more alcohol precipitation, water precipitation, second alcohol precipitation, water precipitation, ultrafiltration and concentration to make oral solid preparation.

Embodiment 2

[0099] The preparation method of the Shenkang oral solid compound preparation of the present invention is as follows: take rhubarb and salvia, add 7-12 times the amount of the original medicinal material for the first time, soak for 30 minutes, boil for 30 minutes, filter, and add water for the second time. 7-12 times the amount of the original medicinal material, boiled for 30min, filtered, and the third water added was 7-12 times the amount of the original medicinal material, boiled for 30min, filtered, combined three water extracts, concentrated to 1.18 at a relative density of 60℃ ~1.25, add 95% ethanol until the alcohol content of the drug solution is 70%, let stand for 38-60 hours, take the supernatant and filter until it is clear, recover the ethanol to a relative density of 1.18~1.25 at 60℃, add 5% gelatin solution In addition to tanning, add 95% ethanol until the alcohol content is 75%, let stand for 38-60 hours, take the supernatant and filter for clarity, recover the ...

Embodiment 3

[0101] The preparation method of the Shenkang oral solid compound preparation of the present invention is: take rhubarb and salvia, add 10 times the amount of the original medicinal material for the first time, soak for 30min, boil for 30min, filter, and add water for the second time the original medicinal material 8 times the amount, boil for 30min, filter, the third time add water 7 times the amount of the original medicinal material, boil for 30min, filter, combine the three water extracts, concentrate to a relative density of 1.20 ~ 1.22 at 60 ℃, add 95% ethanol , Until the alcohol content of the drug solution is 70%, let stand for 48-60 hours, take the supernatant and filter until clear, recover the ethanol to a relative density of 1.20~1.22 at 60℃, add 5% gelatin solution, remove tanning, add 95% Ethanol, to the alcohol content of 75%, stand for 48-60h, take the supernatant and filter for clarity, recover the ethanol to a relative density of 1.20~1.22 at 60℃, add water to ...

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Abstract

The invention relates to a Shenkang oral solid compound preparation for treating chronic renal failure, which is characterized by being prepared from the following bulk pharmaceutical chemicals: 1500g of rheum officinale, 1500g of roots of red-rooted salvia, 4500g of Astragalus mongholicus and 1500g of red flower. The preparation method comprises the following steps of: after the bulk pharmaceutical chemicals of the rheum officinale and the roots of the red-rooted salvia are extracted in the ratio in the formula, carrying out primary ethanol precipitation, removing tan, carrying out secondary ethanol precipitation and water precipitation, carrying out third ethanol precipitation, and carrying out secondary water precipitation; and then, extracting the red flower and the Astragalus mongholicus in the ratio in the formula, carrying out primary ethanol precipitation and water precipitation, carrying out secondary ethanol precipitation and water precipitation, and condensing and drying to obtain the oral solid compound preparation. The Shenkang oral solid compound preparation has the advantages of precision in regulating the original ratio, high in content of effective ingredients in the unit volume, few precipitations, small side effect, high acting speed and high bioavailability.

Description

Technical field [0001] The invention belongs to a traditional Chinese medicine oral preparation, and particularly relates to a Shenkang oral solid compound preparation for treating chronic renal failure and a preparation method thereof. Background technique [0002] The original patent 200410039418.X discloses a Shenkang suppository and its preparation method. Its prescription protects the scope of use of traditional Chinese medicine and does not have a specific proportioning relationship. Although the prescription case is also disclosed in the patent document embodiment, but The amount of astragalus was large, and astragalus and rhubarb had precipitation reaction, and astragalus and salvia also reacted, and the small amount of astragalus in the compatibility of preparations also affected the efficacy. Because the proportion of traditional Chinese medicine directly affects the efficacy of the preparation, the accuracy of the prescription and the small side effects are crucial. S...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61P13/12
Inventor 曹凤君吕延英詹芳赵兴王光建王俊平
Owner XIAN SHIJISHENGKANG PHARMA IND
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