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Preparation method of Chinese medicinal composition for treating essential hypertension

A technology for essential hypertension and a composition is applied in the field of medicine and achieves the effects of low price, exact curative effect and small side effects

Inactive Publication Date: 2015-02-11
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are not many proprietary Chinese medicines for essential hypertension caused by anti-metabolic syndrome on the market. , and some discontinued use during the application process due to inaccurate curative effect

Method used

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  • Preparation method of Chinese medicinal composition for treating essential hypertension
  • Preparation method of Chinese medicinal composition for treating essential hypertension
  • Preparation method of Chinese medicinal composition for treating essential hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0145] Example 1. The pharmaceutical composition of the present invention (CT-1)

[0146] 6 parts of wine rhubarb, 15 parts of turmeric and 30 parts of cassia

[0147] 30 parts of Uncaria, 30 parts of Fuweizi, 45 parts of Prunella vulgaris

[0148] 30 parts of Dilong, 6 parts of Red Yeast

[0149] Uncaria is soaked in cold water alone (150mL / prescription), and the rest of the medicinal flavor is soaked in cold water for 20min (700mL / prescription), heated to boiling, and decocted for 20min. The medicinal materials and decoction liquid are combined with Uncaria and its soaking liquid. After boiling in a fire, decocting in a slow fire for 5 minutes, pour out the medicinal liquid, and concentrate under reduced pressure at 60-65°C until dry.

Embodiment 2

[0150] Example 2. The pharmaceutical composition of the present invention (CT-5)

[0151] 6 parts of wine rhubarb, 15 parts of turmeric and 30 parts of cassia

[0152] 30 parts of Uncaria, 30 parts of Fuweizi, 45 parts of Prunella vulgaris

[0153] 30 parts of Dilong, 6 parts of Red Yeast

[0154] Add 8 times water to soak the whole recipe for 0.5h, heat to boiling, extract for 1h, filter, add 7 times water to decoct the medicine residue for 1h, filter, discard the medicine residue, combine the two extracts and depressurize at 60~65℃ Concentrate to D60 = 1.05-1.10 to obtain a concentrated solution. After cooling to room temperature, add 95% ethanol and precipitate with alcohol and stir while adding until the supernatant contains 70% alcohol. Let stand for 12 hours, filter, and discard the precipitate. The filtrate is 60%. Concentrate to dryness under reduced pressure at ~65°C.

[0155] Or

[0156] Soak the whole recipe with 5 times water for 0.5h, heat to boiling, extract for 1h, filte...

Embodiment 3

[0170] Example 3 The pharmaceutical composition of the present invention (ZY-1)

[0171] 6 parts of wine rhubarb, 15 parts of turmeric and 30 parts of cassia

[0172] 30 parts of Uncaria, 30 parts of Fuweizi, 45 parts of Prunella vulgaris

[0173] 30 parts of Dilong, 6 parts of Red Yeast

[0174] Rhubarb was extracted with 8 times 50% ethanol for 1 hour, filtered, and the medicine residue was extracted with 8 times 50% ethanol for 1 hour, filtered, and the medicine residue was discarded. The extracts were combined and concentrated under reduced pressure at 60-65°C to 4 times the volume of the medicine. , Dilute with water to 15 times the volume of the medicinal material, let stand for 12h, centrifuge to take the supernatant, D101 purification (1.5 times the amount of medicinal material), load, wash with water (5 column volumes), 80% ethanol elution (7 columns Volume), the eluent is concentrated to dryness under reduced pressure at 60-65°C.

[0175] The turmeric was extracted with 8 ti...

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Abstract

The invention relates to a preparation method of a Chinese medicinal composition for treating essential hypertension. The method is characterized in that the composition is prepared by processing the following bulk medicines by weight: 3-12 parts of rheum officinale; 7.5-30 parts of ginger-processed coptis; 15-60 parts of cassia seeds; 15-60 parts of uncaria rhynchophylla; 15-60 parts of motherwort fruits; 22.5-90 parts of prunella vulgaris; 15-60 parts of lumbricus; and 3-12 parts of red koji. The preparation method consists of the steps of: adding 5-10 times of 60-95% ethanol into the above total formula for immersion of 0.5-1h, heating the mixture to boiling, then conducting extraction for 1-3h as well as filtration, adding 5-10 times of 60-95% ethanol into a medicine residue, and carrying out extraction for 1-3h as well as filtration, removing the medicine residue, merging the two extracting solution, and performing pressure reduced concentration at a temperature of 55-65DEG C till obtaining a fluid extract or dry powder, finally mixing the obtained active substance with a pharmaceutically acceptable carrier according to a routine pharmaceutic technology.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating essential hypertension and a preparation method thereof. Background technique [0002] Diseases of modern civilization represented by metabolic syndrome are closely related to some modern lifestyles and habits. It is a high-risk factor for type 2 diabetes and cardiovascular disease. Early diagnosis and early intervention of metabolic syndrome are helpful for the prevention and treatment of type 2 diabetes and cardiovascular disease. [0003] The definition of metabolic syndrome centers on central obesity with elevated blood pressure, blood glucose, triglycerides, and / or low HDL-C. Among them, waist circumference is used as a diagnostic index for central obesity. [0004] Hypertension is a clinical syndrome mainly manifested by increased systemic arterial pressure. It is the most common cardiovascular disease and can be divided int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61P9/12A61K35/64A61K35/62
Inventor 周水平朱永宏张兰兰马晓慧宋兆辉蔡楠仝小林
Owner TIANJIN TASLY PHARMA CO LTD
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