Separation and/or purification of pneumocandin b0 from c0
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 克塞里尔制药公司
- Publication Date
- 2012-05-30
- Estimated Expiration
- Not applicable · inactive patent
Smart Images
Figure 1 
Figure 2 
Figure 3
Abstract
Description
technical field
[0001] The present invention relates to methods for isolating and purifying echinocandin compounds. Background technique
[0002] Pneumocandins are antifungal cyclic hexapeptide compounds with lipid side chains (see Schwarts et al., 1992, Journal of antibiotics, Vol. 45, No. 12, pp. 1853-1866; Masurekar et al., 1992, Journal of Antibiotics, Vol. 45, No. 12, pp. 1867-1874; Hensens et al., 1992, Journal of Antibiotics, Vol. 45, No. 12, pp. 1875-1885; Schmatz et al., 1992, Journal of Antibiotics, Vol. 45, No. 12, pp. 1886-1891; and Adefarati et al., 1992, Journal of Antibiotics, Vol. 45, No. 12, pp. 1953-1957 and US Patent No. 5,021,341).
[0003] The antifungal activity of echinocandins is related to the inhibition of 1,3β-glucan biosynthesis. The action of 1,3β-glucan synthase, a multisubunit enzyme, is involved in fungal cell wall construction, septum deposition, and ascospore wall assembly. The catalytic subunit of this enzyme complex has been identified...