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Compound rifaximin dry suspension for preventing and treating endometritis of livestock and preparation method for same

A technology of dry suspension and rifaximin, applied in the field of compound rifaximin dry suspension for preventing and treating livestock endometritis and its preparation

Active Publication Date: 2012-06-27
ZHENGZHOU BARY ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been confirmed by medical clinics that New Houttuyfonate Sodium Injection has definite curative effect and high safety, and there is no report of drug-resistant bacteria so far, which is unmatched by other antibiotics

Method used

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  • Compound rifaximin dry suspension for preventing and treating endometritis of livestock and preparation method for same

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] Rifaximin dry suspension (500mg per bottle, containing 50mg of rifaximin and 10mg of neohouttuynin sodium)

[0029] 1. Prescription composition

[0030] 1. Prescription:

[0031] A total of 1000 bottles were prepared

[0032] 2. Prescription:

[0033] A total of 1000 bottles were prepared

[0034] 3. Prescription:

[0035]

[0036] A total of 1000 bottles were prepared

[0037] 4. Prescription:

[0038] A total of 1000 bottles were prepared

[0039] Second, the method

[0040] ① Firstly, the raw materials of rifaximin and neohouttuydin sodium are subjected to ultra-micro treatment to pass through a 800-mesh sieve; ② The excipients in the prescription are dried and pulverized to pass through 100 mesh; ③ Weigh an appropriate amount of processed rifaximin according to the prescription amount Ming and new houttuyniatin sodium and auxiliary materials were mixed for 15 minutes according to the method of equal increase, and mixed evenly; ④ Distribute the eve...

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Abstract

The invention belongs to the field of veterinary medicine, and particularly relates to a compound rifaximin dry suspension for preventing and treating the endometritis of livestock and a preparation method for the same. The rifaximin and sodium new houttuyfonate dry suspension is obtained by using rifaximin and sodium new houttuyfonate as active ingredients, and preparing with pharmaceutically acceptable auxiliary materials. The preparation method comprises the following steps of: performing superfine crushing treatment on raw materials at first; uniformly mixing the treated rifaximin and sodium new houttuyfonate with right amount of filler, suspending aid, surfactant, lubricant, adsorbent and pH buffer according to an equivalent incremental mixing method; subpackaging and sterilizing for1 hour by flowing steam at 100 DEG C. Rifaximin is a novel rifamycin board-spectrum semisynthetic antibiotic medicine, with the advantages of board-spectrum antibacterium, antitoxin and the like, andcapable of preventing and treating the endometritis of dairy cow well; and sodium new houttuyfonate is antibacterial, anti-inflammatory and capable of enhancing immunity as well as resisting bacteriaand diminishing inflammation by cooperating with rifaximin, and has great effect of preventing and treating the endometritis of dairy cow.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to a compound rifaximin dry suspension for preventing and treating livestock endometritis and a preparation method thereof. Background technique [0002] Rifaximin (Rifaximin) is a semi-synthetic derivative of rifamycin SV, which is a broad-spectrum, high-efficiency, low-toxic intestinal or topical antibiotic. The drug was developed by the Italian Alpha Company. It was first launched in Italy in 1987 as an anti-infective diarrhea drug, and then widely used in Europe and the United States. In 2004, it was approved by the SFDA for clinical application in my country, mainly for the prevention and treatment of sensitive bacteria. Acute and chronic intestinal infections caused by It has been reported that the marketed dosage forms include dry suspension, capsules, tablets, granules, etc. for oral administration. [0003] Rifaximin has a broad antibacterial spectrum and strong antibacter...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61K31/185A61K9/14A61P15/00A61P31/04A61P29/00
Inventor 余祖功周振雷刘永旺江善祥张军忍
Owner ZHENGZHOU BARY ANIMAL PHARMA
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