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Quick phenolphthalein testing method and test paper utilizing same

A technology of phenolphthalein and test paper, which is applied in the field of preparation of screening test paper, and can solve problems such as arrhythmia, elevated blood sugar, electrolyte disturbance, etc.

Active Publication Date: 2012-06-27
BEIJING INST FOR DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, phenolphthalein can easily cause symptoms such as allergies and pruritus. Long-term use can also increase blood sugar, lower blood potassium, cause electrolyte disturbance in the body, and induce arrhythmia and other hazards.

Method used

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  • Quick phenolphthalein testing method and test paper utilizing same
  • Quick phenolphthalein testing method and test paper utilizing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1, the preparation of phenolphthalein rapid screening test paper

[0056] Take the neutral filter paper and place it in a 5% sodium bicarbonate aqueous solution, soak it for 0.5 minutes, take it out, and dry it at 105 degrees for 10 minutes to obtain the phenolphthalein screening test paper, which can be referred to as test paper T1 in the present invention. In the following, unless otherwise stated, the test was carried out using test paper T1.

[0057] Take the neutral filter paper and place it in a 2% sodium bicarbonate aqueous solution, soak it for 2 minutes, take it out, and dry it at 100 degrees for 20 minutes to obtain the phenolphthalein screening test paper, which can be referred to as test paper T2 in the present invention.

[0058] Take the neutral filter paper and place it in a 10% sodium bicarbonate aqueous solution, soak it for 30 seconds, take it out, and dry it at 110 degrees for 5 minutes to obtain the phenolphthalein screening test paper, w...

Embodiment 2

[0062] Embodiment 2, detect the general operating conditions of whether phenolphthalein is contained in medicine / health product

[0063] 1. Sampling volume:

[0064] Sampling recommendations for different types of samples are as follows:

[0065] sample type

Sampling volume

tablet

1 piece (to be crushed)

Capsules

Contents of 1 capsule

tea

1 / 2 bag

small water pill

1 / 2 of each dosage (must be crushed)

single dose oral solution

1 / 2 stick

other solid

0.1~0.5g (must be crushed)

[0066] It can be seen that the amount of the sample to be inspected used by the method of the present invention is very small, so as to damage the interests of innocent operators as little as possible.

[0067] 2. Preparation of test solution, color development and result judgment

[0068] Take the test sample and add it to 2ml of 40% ethanol aqueous solution, shake for 0.5 minutes; dip the test paper into the test so...

Embodiment 3

[0069] Embodiment 3, test whether there is phenolphthalein in detection medicine, health food and food

[0070] The method of Example 2 was adopted to detect 20 batches of commercially available samples (labeled as medicine, health food or food). The samples were then tested by the LCMS method in accordance with the "National Drug and Food Administration Drug Inspection Supplementary Inspection Methods and Inspection Items Approval Document 2006004". The LCMS method is as follows:

[0071] Take solid or liquid medicine, health food or food according to the table, add 2ml of 40% ethanol solution, and shake for 0.5 minutes. Immerse the test paper T1 into the test solution for 5 seconds, take it out, if the test paper turns rose red to red within 30 seconds, it is judged that the sample may contain phenolphthalein, otherwise, it is judged to be free of phenolphthalein.

[0072] The testing methods of LCMS recorded in the Approval Document 2006004 of Supplementary Testing Meth...

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Abstract

The invention relates to a quick phenolphthalein testing method and test paper utilizing the same. The quick phenolphthalein testing method includes the following steps: (1) taking a product in a proper quantity, mixing the product with ethanol water while shaking to obtain mixed solution; (2), taking phenolphthalein screening test paper impregnated with sodium bicarbonate, impregnating the phenolphthalein screening test paper into the mixed solution prepared at the step (1) and then taking out the test paper; or dipping or sucking a little mixed solution prepared at the step (1) onto the phenolphthalein screening test paper; (3) observing color change of the test paper and judging whether the product contains phenolphthalein or not, and judging the product contains phenolphthalein possibly if the test paper is in rose red and / or red, otherwise, judging the product contains no phenolphthalein. The testing method is convenient and quick in operation, the impregnation solution for the test paper and the product solvent are safe and nontoxic, and the method is suitable for common consumers to test phenolphthalein which is added into products illegally.

Description

technical field [0001] The invention relates to the technical field of analysis of medicine, health food or food, in particular to a preparation method and detection method of a screening test paper for quickly screening medicine, health food or food illegally added phenolphthalein based on chemical reaction. Background technique [0002] With the improvement of living standards, people realize that obesity affects their image and physical health, and they also realize that using western medicine to lose weight will bring serious side effects. However, some unscrupulous manufacturers take advantage of the misunderstanding that consumers are eager to lose weight and that traditional Chinese medicine has no toxic and side effects, and add a large number of chemical weight-loss drugs and laxatives that are prohibited by law in weight-loss Chinese patent medicines, health foods and foods to enhance their weight-loss effects. Taking it many times without knowing it has caused ser...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78
Inventor 王威王铁松车宝泉张喆高青王志斌方颖郭洪祝赵明
Owner BEIJING INST FOR DRUG CONTROL