37results about How to "Reduce chain length" patented technology

The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence.

A rear dérailleur device is provided, in particular for a bicycle equipped with a front dérailleur and a chain connecting a set of pinions with a set of disks. The rear dérailleur device includes a rotatable base provided with a return spring forcing the base in the anti-clockwise direction, guiding/dérailleur means fixedly connected with the base, and a movable tension plate fixedly connected with the guiding/dérailleur means.

The invention provides vaccines against Neisseria meningitidis, pneumococcus and DTPa/w. In particular, it provides vaccines based on conjugated capsular saccharides from multiple meningococcal and/or pneumococcal serogroups. It further provides vaccine administration schemes for the immunisation of human patients with two or more of these vaccines.

A system is used for treating contaminated water, that may include some amount of polyacrylamides, emulsified hydrocarbons, and sequestered divalent cations. The system includes at least one pre-treatment tank for initial processing of the contaminated water. Thereafter, the water may be fed to at least one chemical treatment tank fluidically connected to the pre-treatment tank. This treatment tank includes a chemical injection system connected to an interior thereof for introducing a variety break operations, coagulant addition operations, and/or flocculent addition operations. At least one clarifier is fluidically connected to the at least one chemical treatment tank, and includes a mechanical contaminant removal system. A filter skid is fluidically connected to the at least one clarifier, and includes a plurality of filter cartridges.

Disclosed is a process for producing copolyesters with high levels of recycled content. Scrap or post-consumer poly(ethylene terephthalate) is depolymerized by methanolysis or glycolysis to produce a purified, recycled dimethyl terephthalate which can be repolymerized with 2 or more diols. The polyesters of this invention have physical properties and an appearance that is similar to polyesters prepared from virgin monomers. In addition to dimethyl terephthalate, the polyesters can be prepared from recycled ethylene glycol recovered from depolymerization of poly(ethylene terephthalate) and/or 1,4-cyclo-hexanedimethanol prepared by hydrogenation of recycled dimethyl terephthalate or recovered from depolymerized polyester mixtures.

The invention pertains to heat transfer compositions, particularly to automobile refrigerants comprising a hydrofluoroalkene, an iodocarbon, and at least one lubricant having hydrogen atoms and carbon atoms, wherein no more than 17% of the total number of hydrogen atoms which are attached to a carbon atom are tertiary hydrogen atoms.

The invention pertains to heat transfer compositions, particularly to automobile refrigerants comprising a hydrofluoroalkene, an iodocarbon, a lubricant and a metal stabilizer.

A method for removing iodine and iodide ions from heat transfer compositions which contain a hydrofluoroalkene, an iodocarbon, and iodine and iodide ions. Iodine and iodide ions from such heat transfer compositions by contacting the composition with a molecular sieve, ion exchange resin, clay or alumina, metal impregnated with a metal which is capable of reacting with iodine and iodide ions.

Conjugated meningococcal capsular saccharides will be introduced into immunisation schedules in the near future, but the phenomenon of “carrier suppression” must first be addressed, particularly where multiple conjugates are to be used. In the invention, tetanus toxoid is used as the carrier protein, even where multiple meningococcal conjugates are administered at the same time and where a patient has previously been exposed to the carrier protein, either in the form of a previous immunogen (e.g. in a DTP vaccine) or as a previous carrier protein (e.g. in a Hib or pneumococcal conjugate vaccine). The invention provides a method for immunising a patient, comprising administering multiple conjugates of meningococcal capsular saccharides, wherein each conjugate comprises a tetanus toxoid carrier protein, and the capsular saccharide, and wherein the patient has been pre-immunised with a tetanus toxoid.

The invention relates to a preparing method of a lotus seed amylase-aliphatic acid composite having a high composite index number, and belongs to the technical field of modified starch processing. The method includes preparing lotus seed amylase into submicron order particles through superfine grinding, and forming the single-screw V-type amylase-aliphatic acid composite through microwave pretreatment and ultrahigh pressure treatment in assistant. The composite has the ultra-high composite index number and an embedding rate. The method includes steps of preparing the amylase, performing superfine grinding, pretreating aliphatic acids, performing microwave pretreatment, performing ultrahigh pressure compositing, cooling and crystallizing at a low temperature, washing with an alcohol, centrifuging, freeze-drying, smashing and packaging. A product of the method is high in composite index number, good in digestion resistibility and high in embedding rate. Compared with traditional preparing methods, a process of preparing the composite is free of chemical agent addition and high in safety, the composite can provide a sense of satiety and reduce blood glucose when the composite is added into foods, and the composite has a good application prospect.

A method for removing iodine from heat transfer compositions which contain a hydrofluoroalkene, an iodocarbon, and iodine. Iodine from such heat transfer compositions by contacting the composition with activated carbon.

The invention relates to a method for improving the detection sensitivity of cocaine. The method is characterized in that a nucleic acid aptamer for cocaine detection is broken into three sections. The method comprises the following steps of: (1) mixing the cocaine and three sections of nucleic acid aptamer probes to ensure that the detected cocaine and the aptamer probes form a compound; and (2)performing fluorescence detection, electrochemical detection or color detection. As the length of the three sections of nucleic acid probes is obviously shorter than that of one or two sections of nucleic acid probes, the interaction among probes and between the probes and other components in a detection system capable of causing background noise is greatly reduced. Thus the detection sensitivityof the cocaine is greatly improved. Taking the nanogold color detection of the cocaine for example, the sensitivity of the color detection of the cocaine is improved by one magnitude order by the three sections of nucleic acid probes. The method can be popularized to the detection of various materials comprising small molecules and heavy metal ions.

A dual formulation for vaccines against Neisseria meningitidis serogroup B (‘Men-B’) comprises (i) an oil-in-water emulsion adjuvant and (ii) a Men-B immunogenic component in lyophilised form. The lyophilised Men-B antigens can be reconstituted into liquid adjuvanted form at the time of use ready for administration to a patient. This formulation has been found to give excellent result in terms of both stability and immunogenicity. The lyophilised component can also include one or more conjugated saccharides from N. meningitidis in serogroups A, C, W135 and/or Y.

The invention discloses a versatile combined rowing and swinging bicycle, which is characterized in that: an inner sleeve at the front end of a beam [1] is inserted and locked with a C-shaped outer sleeve with a seat slide way at the rear end of the beam [1], the top end of the inner sleeve of the beam [1] is connected with a front fork [4] via a shaft, pedal devices [11] are installed at the both ends of the cross beam of the front fork [4], the lower end of the front fork [4] inclines inwards and extends to be connected with the front axles of two wheels, the C-shaped outer sleeve of the beam [1] is inserted and locked with a shaft on the top of a beam column [2], and a slide seat [9] is installed on the slide way of the beam [1] to compose a combined swinging bicycle. The combined swinging bicycle becomes a road snow stick swinging bicycle in case that a double-rod road snow stick with a rubber head is used, becomes a road single-paddle swinging bicycle in case that a double-blade road single paddle with a rubber head is used, and becomes a versatile combined rowing and swinging bicycle in case that a versatile double-rod D-shaped chain disc rowing device is used; and the combined swinging bicycle may become a unique and novel foot-controlled electric swinging bicycle or rowing and swinging bicycle by adding a motor device. The bicycle is easy to detach and combine, as well as is an ideal instrument for the sports events, exercise and rehabilitation of people.

Carrier-induced epitopic suppression is of particular concern where multiple conjugates with the same carrier protein are administered simultaneously. To avoid the suppression, the invention minimises the amount of unconjugated carrier protein in a vaccine. The invention provides a composition for immunising a patient against a disease caused by Neisseria meningitidis, wherein (1) the composition comprises conjugates for at least two of the four meningococcal serogroups A, C, W135 and Y, where at least two of the conjugates have a common carrier protein; and (2) the composition includes the common carrier in an unconjugated form at less than 10 μg/ml.

The present invention relates to the use of monomers bearing associative groups in order to manufacture a supramolecular polycondensate, to certain of these monomers, to a process for manufacturing a supramolecular polycondensate, to the polycondensate obtained, and also to an article or a composition incorporating same.

The subject invention concerns methods revealing surface imperfections on an object comprising the steps of: coating the surface to be inspected with a composition comprising an opaque, water-dispersible liquid, sufficiently surface-adherent and with surface-wetting properties as to create a gloss finish, at least before the liquid dries, on the restored area; inspecting the surface to check for imperfections; and removing said composition with water. The method may also include a step of marking the surface, through the wet composition layer, to indicate the location of imperfections discovered. Also described are compositions and delivery systems suitable for carrying out the method comprising aqueous dispersions of a pigment and a resin, especially a polysaccharide resin.

The invention belongs to the technical field of food processing, in particular to a normal-temperature fresh keeping method of fresh wet instant rice noodles. The method comprises the steps of S1, performing enzymolysis; S2, performing material mixing; S3, performing first-stage extruding and curing; S4, performing second-stage extruding and shaping; S5, performing cooling and splitting; S6, performing ageing; S7, performing steaming; S8, performing packaging; and S9, performing superhigh pressure sterilization so as to obtain products. In the method, a composite fresh keeping agent cooperateswith a superhigh pressure sterilization technique, so that various microorganisms in rice noodles can be effectively killed; through a cold sterilizing technique, fresh keeping effects are guaranteed, nutrition and flavor of the fresh wet rice noodles are not influenced; and in order to guarantee the whole quality of the rice noodles in the storage period, through synergistic reactions of cross-linking modified starch, modified soybean phospholipid and maltogenic amylase, the ageing speed of the fresh wet rice noodles in the normal-temperature fresh keeping process can be delayed.

The invention discloses a preparation method of a high-water-flux high-toughness nanofiltration membrane, and belongs to the technical field of separation membranes. The method comprises the followingsteps: adding graphite into sulfuric acid and mixing; after mixing, adding potassium ferrate and stirring to obtain an oxidation reaction solution; carrying out suction filtration on the oxidation reaction liquid to obtain filter residues; mixing and crushing the filter residues and cotton; crushing, mixing with cellulase, and carrying out enzymolysis treatment to obtain an enzymolysis product; mixing and heating the enzymolysis product and distilled water; dropwise adding alkali liquor and stirring to obtain an alkaline mixed solution; adding iodine into the alkaline mixed solution; adding sodium sulfite and stirring to obtain a reaction mixed solution; dropwise adding hydrochloric acid into the reaction mixed solution, and performing vacuum drying and high-temperature treatment to obtain a fiber toughening agent; finally mixing the fiber toughening agent, an ethanol solution and methylbenzene to obtain a prefabricated solution, soaking a membrane into the prefabricated solution, drying and washing after soaking to obtain the high-water-flux high-toughness nanofiltration membrane. The nanofiltration membrane has improved mechanical strength and toughness.