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Application of cobra venom nerve growth factor in preparing the medicine of preventing and treating liver fibrosis and liver cirrhosis

A technology of nerve growth factor and cobra venom, which is applied in drug combination, digestive system, pharmaceutical formula, etc., can solve the problems of poor use effect and unsatisfactory therapeutic effect

Inactive Publication Date: 2012-07-11
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to side effects or poor use effects, these drugs have failed to achieve satisfactory therapeutic effects

Method used

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  • Application of cobra venom nerve growth factor in preparing the medicine of preventing and treating liver fibrosis and liver cirrhosis
  • Application of cobra venom nerve growth factor in preparing the medicine of preventing and treating liver fibrosis and liver cirrhosis
  • Application of cobra venom nerve growth factor in preparing the medicine of preventing and treating liver fibrosis and liver cirrhosis

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Experimental program
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Effect test

Embodiment Construction

[0020] The specific implementation manners of the present invention will be described in further detail below in conjunction with the accompanying drawings.

[0021] Application of cobra venom nerve growth factor in the preparation of drugs for preventing and treating liver fibrosis and liver cirrhosis

[0022] 1. Preparation of cobra venom nerve growth factor

[0023] 1. Separation and purification of NGF from cobra venom

[0024] The crude snake venom was eluted on a Sephadex G-75 gel column with 1% HAC for preliminary separation, and the collected solutions of each peak were tested for NGF activity by PC-12. Use CM Sepharose CL-6B ion column to carry out linear elution to active peak again through 1mol / l NaCl and 0.025mol / l NaAC-HAC (pH5.8buffer) mixed liquid; Carry out NGF activity identification to the elution peak of further separation, and The purity and relative molecular mass of the NGF active peak were identified by SDS-PAGE.

[0025] 2. Identification of the biol...

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Abstract

The invention discloses an application of cobra venom nerve growth factor in preparing the medicine of preventing and treating liver fibrosis and liver cirrhosis. The study indicates that the cobra venom nerve growth factor has the effects of inducing apoptosis in HSC-T6, resisting liver fibrosis at the cellular level and in animals, and effectively inhibiting or reducing the degree of hepatic fibrosis. Taking the cobra venom nerve growth factor as a medicinal main active ingredient, the application has the advantages of remarkable efficacy, fast effect, safety and efficacy, few side effects. The cobra venom nerve growth factor is an ideal medicine of preventing and treating liver fibrosis and liver cirrhosis.

Description

technical field [0001] The invention relates to a new medical application of the cobra venom nerve growth factor, in particular to the application of the cobra venom nerve growth factor in the preparation of drugs for preventing and treating liver fibrosis and liver cirrhosis. Background technique [0002] Epidemiological surveys show that in my country, 10%-15% of hepatitis B, especially chronic active hepatitis, may develop into post-hepatitis cirrhosis within 5-10 years. There are about 30 million chronic hepatitis patients in my country, all of whom may or have developed liver fibrosis. Because there is no effective eradication method for liver damage caused by hepatitis virus, it often slowly develops into liver fibrosis, and finally cirrhosis. It can be seen that liver fibrosis caused by hepatitis virus infection is seriously harmful. In addition to hepatitis virus infection, hepatic fibrosis can be caused by parasitic infection, alcohol, malnutrition and radiation. F...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P1/16
Inventor 张学荣罗小玲赖允丽廖明林兴胡仁统班建东廖共山陈缨农君
Owner GUANGXI MEDICAL UNIVERSITY
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