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Methylcobalamin injection lamp inspection method

A technology of injection and methylcobalamin, which is applied in the field of light inspection of methylcobalamin injection, can solve the problems of poor quality and safety, instability to light, and easy failure, etc., and achieves a high degree of automation and detection High efficiency and high detection sensitivity

Inactive Publication Date: 2012-07-11
YANGTZE RIVER PHARM GRP NANJING HAILING PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, methylcobalamin preparations are very unstable to light and are prone to failure under strong light. Therefore, they need to be produced and tested under dark conditions. However, it is difficult to operate completely in the dark, and it is difficult to operate manually without seeing the real thing during operation, which is difficult for production and testing. It brings a lot of inconvenience, and the manual naked eye detection has a large error, and the quality and safety cannot be well guaranteed

Method used

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  • Methylcobalamin injection lamp inspection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A kind of methylcobalamin injection lamp inspection method, it comprises the following steps:

[0023] a. Divide the light sources of the light inspection machine into 4 groups. The first group of light sources T1 and T2 are used for the appearance inspection of methylcobalamin injection, and the second group of light sources T3 and T4 are used for the detection of reflection and refraction foreign objects in methylcobalamin injection. , the third group of light sources T5 and T6 are used for the detection of non-reflective or non-refractive foreign objects in methylcobalamin injection; the fourth group of light sources T7 and T8 are used for the detection of reflective and refractive foreign objects in methylcobalamin injection, and then Each light source of T8 is wrapped with 2 layers of red filters with a thickness of 0.3 mm, and then the illuminance of each light source of the light inspection machine is adjusted within 250 to 500 lux;

[0024] b. If figure 1 Shown...

Embodiment 2

[0027] A kind of methylcobalamin injection lamp inspection method, it comprises the following steps:

[0028] a. Divide the light sources of the light inspection machine into 4 groups. The first group of light sources T1 and T2 are used for the appearance inspection of methylcobalamin injection, and the second group of light sources T3 and T4 are used for the detection of reflection and refraction foreign objects in methylcobalamin injection. , the third group of light sources T5 and T6 are used for the detection of non-reflective or non-refractive foreign objects in methylcobalamin injection; the fourth group of light sources T7 and T8 are used for the detection of reflective and refractive foreign objects in methylcobalamin injection, and then Each light source of T8 is wrapped with 2 layers of red filters with a thickness of 0.3mm, and then adjust the light intensity of the first group of light sources T1 and T2 of the light inspection machine to be 250 to 300 lux, and the l...

Embodiment 3

[0031] Example 3 Screening of the light source filter of the lamp inspection machine

[0032]1. The present invention is screened with filters of different colors on the light source of the lamp inspection machine through a large number of experiments. The specific experimental results are as shown in Table 1. The filters of red, blue and purple are preliminarily determined. The test results show that the composition of methylcobalamin injection will not change if the red filter is selected, and the red filter is selected. At the same time, the present invention has carried out a screening experiment on the thickness of the filter. (1 group), place 1 filter at each light source (2 groups), place 2 filters at each light source (3 groups) for testing, place 3 filters at each light source (4 groups) The test is carried out, and each test is carried out three times in a row, and the test with the selected illuminance within 200-500 lux (LUX) is carried out. The specific experimen...

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Abstract

The invention discloses a methylcobalamin injection lamp inspection method. By adopting the lamp inspection method to inspect methylcobalamin injection, the traditional concept that methylcobalamin cannot be inspected under light is broken through. According to a great number of experiments for selecting the magnitudes of illumination intensity, the types of light sources and the types and the thickness of filters and aiming at different inspection requirements for methylcobalamin preparations, the magnitudes of illumination intensity for methylcobalamin visual inspection, reflective and refractive foreign matter inspection and non-reflective or non-refractive foreign matter inspection are respectively selected. Compared with the traditional manual inspection method, the methylcobalamin injection lamp inspection method has the advantages that the automation level is high, the inspection sensitivity is high, the inspection efficiency is high, the inspection result is accurate and reliable and the quality of the methylcobalamin is not influenced.

Description

[0001] technical field [0002] The invention relates to a drug detection method, in particular to a lamp detection method for methylcobalamin injection. Background technique [0003] In the field of medicine and pharmaceuticals, some drugs that are unstable to light need to be produced under the condition of avoiding light during the production process, such as the methylcobalamin injection product produced by Nanjing Hailing Pharmaceutical Co., Ltd. of Yangzijiang Pharmaceutical Group. The chemical name is: Coα -[α-(5,6)-Dimethylbenzimidazolyl]-Coβ-methylcobalamide, whose trade name is Qixin, is widely used clinically for multiple neuritis and trigeminal neuralgia; sequelae of brain accidents, Neurological disorders caused by traumatic brain injury and arteriosclerosis; insomnia, dreaminess, irritability, irritability; alcoholic neuritis; autonomic nervous disorders, etc. However, methylcobalamin preparations are very unstable to light and are prone to failure under stron...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/90
Inventor 戚小兵曹吉安倪洪旭
Owner YANGTZE RIVER PHARM GRP NANJING HAILING PHARM CO LTD
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