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Novel pharmaceutical formulations against drug misuse

A technology of granules and compounds, applied in the field of new pharmaceutical formulations for preventing drug abuse, can solve the problems of difficulty in preventing the extraction of active ingredients, inability to prevent illegal extraction of active ingredients, etc.

Active Publication Date: 2013-08-21
DEBREGEAS & ASSOCIES PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even with this formulation, it is difficult to prevent the use of solvents to extract the active ingredient
[0012] Therefore, although there are currently some sedatives with different formulations in the world to improve the abuse of such drugs, all these methods cannot prevent the illegal extraction of active ingredients

Method used

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  • Novel pharmaceutical formulations against drug misuse
  • Novel pharmaceutical formulations against drug misuse
  • Novel pharmaceutical formulations against drug misuse

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Example 1 : Tablets based on morphine sulfate

[0113]

[0114]

[0115] Utilize following operating process to both obtain above-mentioned tablet:

[0116] denatonium benzoate Silicone ( 972), talc, sodium bicarbonate (gas-releasing compound), and patent blue (colorant) to make an initial mixture (mixture 1). put these mixtures in Mix in a mixer for 10 minutes.

[0117] The pulverized active ingredient was poured into a mixer to prepare a second mixture (mixture 2). Then, the mixture was stirred and mixed with HPMC for 20 minutes.

[0118] Next, mix 1 was introduced into mix 2 and mixed for an additional 20 minutes.

[0119] The resulting blend was then subjected to direct compression on a Korch3 tablet press, whereby finished tablets were produced.

[0120] Then, this tablet was mixed with The coating solution of LP, pigment and magnesium stearate is used for suspension coating and spraying.

Embodiment 2

[0121] Example 2 : Oxycodone-based granules

[0122]

[0123] Utilize following operation process to both obtain above-mentioned granule:

[0124] First, the active suspension is prepared, i.e. the preparation contains the active ingredient (oxycodone), binder (PVP), coloring and bittering agent suspension.

[0125] Then, the above suspension was sprayed onto the support (mannitol granules in a fluidized air bed), and the granules were dried in a fluidized air bed.

[0126] An initial mixture (mixture 1) was prepared using granules based on mannitol, microcrystalline cellulose and sodium glycine carbonate (a gas-releasing compound).

[0127] A second mixture (mixture 2) was then prepared on the basis of the above-mentioned active ingredient-containing granules. These granules are air-dried, and then the granules are reintroduced into the mixer, and the color and lubricant are added.

[0128] Finally, the mixtures 1 and 2 were stirred and mixed for measurement and qua...

Embodiment 3

[0129] Example 3 : Buprenorphine-based capsules

[0130]

[0131]

[0132] Obtain above-mentioned capsule according to following operating process:

[0133] The neutral carrier (sugar / starch) is placed in a conventional mixer to prepare an aqueous suspension containing the active ingredient (buprenorphine), binder and bittering agent. Sodium bicarbonate (a gas-releasing compound) is attached to the sugar and starch carrier by a pulverization process, alternating pulverization and suspension spraying steps.

[0134] Next, the obtained granules are dried in a blender.

[0135] Then, it is coated with an ethylcellulose aqueous suspension containing plasticizers, pigments and talc.

[0136] The granules are then further dried to harden the film.

[0137] Finally, the capsule granules are subpackaged.

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Abstract

Granules having a solid core on which an active ingredient is supported, the core being chosen preferably from among insoluble supports, the granules also having, supported on said the core, the following compounds: one or more colouring agents, one or more metallic pigments, one or more gas-releasing compounds, and optionally one or more embittering agents.

Description

technical field [0001] The purpose of the present invention is to research out the formula of novel medicament, be used for reducing or avoiding drug abuse phenomenon. Background technique [0002] Substance abuse is the inappropriate use of drugs. Drug abuse is becoming more and more serious and has become a major problem that damages public health. At the root of drug abuse is a vague understanding of certain active ingredients that are both medically sedative and legally prohibited. [0003] There are several purposive explanations for the presence of substance abuse behavior, such as pursuit of psychological or physical stimulation; pleasure-seeking (parties or raves); addiction problems after initial use; pain relief or psychosis; chemical control in some cases (e.g. post-drug sexual abuse); and occasional actual treatment drug misuse or inappropriate use (e.g. due to lack of understanding among some older adults). [0004] The consequences of drug abuse are also var...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K9/20A61K9/48
CPCA61K9/2013A61K9/1652A61K9/2054A61K9/4866A61K9/167A61K9/2018A61K9/2077A61K9/4858A61K9/2009A61K9/1623A61K31/485A61K31/352A61K31/5513A61K31/135A61K31/197A61K31/27A61K9/1676A61K9/0007A61K2800/43A61K2800/22A61P25/00A61P25/04A61P29/00A61P29/02A61K9/16A61K9/20A61K9/48A61K9/1694A61K9/1611A61K33/10A61K8/732A61K8/23A61K8/41A61K51/0489A61K33/08A61K8/29A61K2300/00
Inventor 帕斯卡·祖普利克里斯托弗·勒邦
Owner DEBREGEAS & ASSOCIES PHARMA
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