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Application of hesperetin in preparation process of drugs for treating allergic asthma

A technology of allergic asthma and hesperetin, which is applied in the direction of drug combination, pharmaceutical formula, organic active ingredients, etc., can solve the problems that have not been found in the report of the application of hesperetin, and achieve the inhibition of tracheal smooth muscle contraction response and no toxic side effects Effect

Inactive Publication Date: 2012-07-18
李康
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the application of tangeretin in allergic asthma medicines

Method used

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  • Application of hesperetin in preparation process of drugs for treating allergic asthma
  • Application of hesperetin in preparation process of drugs for treating allergic asthma
  • Application of hesperetin in preparation process of drugs for treating allergic asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The following will illustrate the inhibitory effect of tangeretin on His-induced contraction of isolated guinea pig tracheal strips in combination with specific experiments.

[0016] 1. Drugs and reagents

[0017] Theophylline sustained-release tablets (Guangzhou Maite Xinghua Pharmaceutical Factory Co., Ltd., batch number: 20101008, specifications: 100mg / tablet, dissolved in ethanol); histamine phosphate (His, Guangzhou Qiyun Biotechnology Co., Ltd., dissolved in distilled water); Kirkner solution (K-H): NaCl 7.5g, KCl 0.35g, NaH 2 PO4 0.1 g, NaHCO 3 1.0 g, MgCl 2 0.05 g, CaCl 2 0.24 g (the above reagents are from Guangzhou Chemical Reagent Factory), glucose 1 g (Tianjin Damao Chemical Reagent Factory), and CaCl 2 Dissolve completely with distilled water, then add the remaining 6 substances to dissolve, transfer to a volumetric flask, and dilute to 1000 ml with distilled water, all the above reagents are of analytical grade.

[0018] 2. Preparation of Tangereti...

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PUM

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Abstract

The invention discloses the application of hesperetin in the preparation process of drugs for treating allergic asthma. The application proves that hesperetin achieves an antagonistic histamine effect, is H1 receptor blockers, achieves obvious inhibitory action to tracheal smooth muscle contraction response caused by His (histidine), applies the dose less than the dose of theophylline sustained-release tablets when achieving the same inhibition rate (50 percent) compared with the theophylline sustained-release tablets that are positive control drugs, is 1 / 4.5 of the dose of the theophylline sustained-release tablets approximately, has no toxic and side effect approximately, and is a drug that has development prospect and treats allergic asthma.

Description

technical field [0001] The invention relates to a new application of tangeretin, in particular to the application of tangeretin in the preparation of medicines for treating allergic asthma. Background technique [0002] Tangeretin, chemically named 5,6,7,8,4'-pentamethoxyflavone, is a published compound whose structure is: [0003] . The compound is a white crystal, which is used as a bittering agent. It can also be used as a sweetener through hydrolysis and hydrogenation to obtain naringin dihydrochalcone. The sweetness is about 150 times that of sucrose. Tangeretin also has antifungal effects, and can inhibit the proliferation of subtype tumor cells in vitro. [0004] CN101257911A discloses a method for controlling fat accumulation in adipocytes, which discloses that orange peel has the effect of controlling fat accumulation in adipocytes. [0005] CN101947215A Application of flavonoids in tangerine peel in the preparation of drugs for inhibiting angiogenesis disclose...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P11/06
Inventor 李康
Owner 李康