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Composition for protecting lever and achieving sobering function

A composition and sobering technology, applied in the fields of drug combination, active ingredients of heterocyclic compounds, food science, etc., can solve the problems of non-effective treatment drugs for NAFLD and so on

Active Publication Date: 2012-07-18
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, modern medicine has no specific therapeutic drugs for NAFLD. Therefore, from the perspective of traditional Chinese medicine, it has become a research hotspot to find drugs that can better block the progress of NAFLD or treat and improve patients.

Method used

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  • Composition for protecting lever and achieving sobering function
  • Composition for protecting lever and achieving sobering function
  • Composition for protecting lever and achieving sobering function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Acute Toxicology Experiment

[0088] The acute toxicology experiment was carried out according to the national standard test. Kunming mice were selected, 20-25g, 10 males and 10 males and females. They were fed with standard feed, free to drink water, and entered the experiment after adaptive feeding for 1 week. All mice were fasted before the experiment. After 16 hours of involuntary water, then give the compound according to 10 times of the high-dose group, observe continuously for two weeks, and observe the state and defecation and defecation of the mice (Yuan Bojun. Drug Toxicology Experimental Methods and Techniques [M]. Chemical Industry Press, 2007.).

[0089] The mice were continuously observed for two weeks after administration, and no abnormalities were found. According to the judgment of the acute toxicology test in the national standard test, it can be seen that the compound will not produce any side effects.

Embodiment 2

[0091] Preventive efficacy of compound recipe on ethanol-induced acute alcoholic liver injury

[0092] Hovenia dulcis, also known as longevity fruit, has been reported by many studies to have a good sobering effect, so Hovenia dulcis extract alone was selected as a positive control. Select 84 (18-22g) male mice of SPF grade Kunming, and divide them randomly into 7 groups of A, B, C, D, E, F, and G according to body weight, with 12 mice in each group. The mice in each group are fed with standard diet Feed, drink water freely, and enter the experiment after 1 week of adaptive feeding. Before the experiment, the mice in each group were fasted for 10 hours. Group A (model group) was given distilled water. Group (Hovenia dulcis low-dose group), F group (Hovenia dulcis middle-dose group), G group (Hovenia dulcis high-dose group) were given the medicine of setting dose respectively, after 45min, each group of animals was given 56% ethanol solution (15ml / kg BW). Observe the situati...

Embodiment 3

[0098] Therapeutic Efficacy of Compound on Ethanol-Induced Acute Alcoholic Liver Injury

[0099] Select 84 SPF grade Kunming male mice (18-22g), and divide them randomly into 7 groups of A, B, C, D, E, F and G according to body weight, with 12 mice in each group. The mice in each group are fed with standard diet Feed, drink water freely, and enter the experiment after 1 week of adaptive feeding. Before the experiment, the mice in each group were fasted for 10 hours. Group A (model group) was given distilled water. Group (Hovenia dulcis low-dose group), F group (Hovenia dulcis middle-dose group), G group (Hovenia dulcis high-dose group) were given the medicine of setting dosage respectively, and each group of animals was given 56% ethanol solution (15ml / kg BW). Observe the situation of the mice from intoxication to drunkenness. Whether the mouse is drunk or not is based on the disappearance of the righting reflex (Xu Shuyun, Bian Rulian, Chen Xiu. Pharmacological Experiment...

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Abstract

The invention discloses a composition for protecting lever and achieving a sobering function as well as a preparation method and application of the composition. The composition contains 30-180 parts by weight of sesamin, 1-6 parts by weight of schisandrin B, 150-900 parts by weight of semen hoveniae extract, 150-900 parts by weight of pueraria lobata extract, 0.0012-0.0072 parts by weight of vitamin B12 and 14-84 parts by weight of vitamin E.

Description

technical field [0001] The present invention relates to liver protection, in particular to a liver-promoting and protective composition. Background technique [0002] Alcoholic liver disease (ALD) refers to liver damage caused by long-term and heavy drinking of alcoholic beverages. It usually manifests as fatty liver at the initial stage, and then can develop into alcoholic hepatitis, alcoholic liver fibrosis and Alcoholic cirrhosis. Alcoholism has become a worldwide public health problem, but so far there is no specific drug for the prevention and treatment of alcoholic liver disease, and traditional Chinese medicine has shown more and more advantages. At the same time, with the changes in lifestyle and diet structure in recent years, the incidence of nonalcoholic fatty liver disease (NAFLD) is increasing all over the world, and it is getting younger and younger. As one of the causes of end-stage liver disease, it has been paid more and more attention clinically. However...

Claims

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Application Information

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IPC IPC(8): A61K36/752A23L1/29A61P1/16A61P25/32A61K31/355A61K31/36A61K31/714A23L33/00
Inventor 王福俤周玉付郭艳红
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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