Composition for protecting lever and achieving sobering function
A composition and technology of sobering up, applied in the direction of drug combination, active ingredients of heterocyclic compounds, food science, etc., can solve the problem of non-specific therapeutic drugs for NAFLD
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Embodiment 1
[0087] Acute Toxicology Experiment
[0088] The acute toxicology experiment was carried out according to the national standard test. Kunming mice were selected, 20-25g, 10 males and 10 males and females. They were fed with standard feed, free to drink water, and entered the experiment after adaptive feeding for 1 week. All mice were fasted before the experiment. After 16 hours of involuntary water, then give the compound according to 10 times of the high-dose group, observe continuously for two weeks, and observe the state and defecation and defecation of the mice (Yuan Bojun. Drug Toxicology Experimental Methods and Techniques [M]. Chemical Industry Press, 2007.).
[0089] The mice were continuously observed for two weeks after administration, and no abnormalities were found. According to the judgment of the acute toxicology test in the national standard test, it can be seen that the compound will not produce any side effects.
Embodiment 2
[0091] Preventive efficacy of compound recipe on ethanol-induced acute alcoholic liver injury
[0092] Hovenia dulcis, also known as longevity fruit, has been reported by many studies to have a good sobering effect, so Hovenia dulcis extract alone was selected as a positive control. Select 84 (18-22g) male mice of SPF grade Kunming, and divide them randomly into 7 groups of A, B, C, D, E, F, and G according to body weight, with 12 mice in each group. The mice in each group are fed with standard diet Feed, drink water freely, and enter the experiment after 1 week of adaptive feeding. Before the experiment, the mice in each group were fasted for 10 hours. Group A (model group) was given distilled water. Group (Hovenia dulcis low-dose group), F group (Hovenia dulcis middle-dose group), G group (Hovenia dulcis high-dose group) were given the medicine of setting dose respectively, after 45min, each group of animals was given 56% ethanol solution (15ml / kg BW). Observe the situati...
Embodiment 3
[0098] Therapeutic Efficacy of Compound on Ethanol-Induced Acute Alcoholic Liver Injury
[0099] Select 84 SPF grade Kunming male mice (18-22g), and divide them randomly into 7 groups of A, B, C, D, E, F and G according to body weight, with 12 mice in each group. The mice in each group are fed with standard diet Feed, drink water freely, and enter the experiment after 1 week of adaptive feeding. Before the experiment, the mice in each group were fasted for 10 hours. Group A (model group) was given distilled water. Group (Hovenia dulcis low-dose group), F group (Hovenia dulcis middle-dose group), G group (Hovenia dulcis high-dose group) were given the medicine of setting dosage respectively, and each group of animals was given 56% ethanol solution (15ml / kg BW). Observe the situation of the mice from intoxication to drunkenness. Whether the mouse is drunk or not is based on the disappearance of the righting reflex (Xu Shuyun, Bian Rulian, Chen Xiu. Pharmacological Experiment...
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