Preparation method and application of molecularly imprinted polymer for directionally protecting functional groups

Abstract

The invention provides a preparation method of a molecularly imprinted polymer for directionally protecting functional groups. Two molecularly imprinted polymers are synthesized by using 200-400 meshes of macroporous aminomethyl resin microspheres subjected to double-bond modification as a carrier, methacrylic acid as a monomer, and 2-methyl cyclopentanol as a template or 4-vinyl pyridine as a monomer and 5,6,7,8-tetrahydrogen-2-naphthol as a template. The preparation method has the advantages that: 1) the molecularly imprinted polymer prepared by a surface imprinted technology has the characteristic of specific identification, i.e. selectively adsorbing functional groups requiring for protection; 2) the molecularly imprinted polymer has the function of non-covalent protection to active groups under a same chemical environment, has strong practicality and can be used for protecting functional groups in directional organic chemical reaction, so that the functional groups can be protected effectively and the purity of an objective product reaches 100%; and 3) the prepared molecularly imprinted polymers as the protecting groups can be used repeatedly, and the reaction cost can be reduced, thus the molecularly imprinted polymer is applicable for being popularized in production process.

Description

【Technical field】 [0001] The invention belongs to the technical field of synthesis and application of molecularly imprinted polymers, in particular to a preparation method and application of molecularly imprinted polymers with directional protection functional groups. 【Background technique】 [0002] The core of molecular imprinting technology is the preparation of molecularly imprinted polymers. The so-called molecularly imprinted polymer is a polymer with specific recognition and high selectivity for template molecules prepared by molecular imprinting technology. The principle of molecularly imprinted polymer preparation is to form derivatives or complexes of template molecules by covalent or non-covalent interactions between template molecules and functional monomers in a solvent, and then use cross-linking agents to cross-link and polymerize to prepare polymers. polymer. After the template molecule is extracted and removed, the polymer skeleton leaves holes complementar...

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Problems solved by technology

However, this selective protection is generally quite complicated, and sometimes it is necessary to synthesize a reactant protected by a functional group from scratch or from an intermediate.

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