MicroRNA (ribonucleic acid) specific expression profile and application thereof

A technology of specific expression profile and differential expression, applied in the field of MicroRNA specific expression profile and its application, tumor biomarkers and its clinical application, can solve the problems of tumor recurrence, one-sided prediction, etc., achieve economical rationality, promote reform, reduce The effect of treatment and medical costs
CN102586412AInactive Publication Date: 2012-07-18SHANGHAI FIRST PEOPLES HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI FIRST PEOPLES HOSPITAL
Publication Date
2012-07-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the fields of biological and medical examination, and relates to microRNA (ribonucleic acid) specific expression profile and clinical application thereof. Tumor recurrence after liver transplantation for liver cancer can be judged by five miRNAs or comprehensive indexes of the microRNA specific expression profile, accuracy rate reaches 77%, further, tumor recurrence and prognosis conditions of an integral case group can be judged, tumor recurrence and prognosis conditions can also be judged for patients after Milan delamination of the patients by the aid of the 5 miRNAs or the comprehensive indexes, accordingly, the microRNA specific expression profile can be used for screening patients with high tumor recurrence risks after clinical liver transplantation for liver cancer, assists in judging prognosis and realizing early diagnosis of recurrence, and provides a basis for early intervention treatment and implementation of individualized treatment.
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Description

Technical field

[0001] The present invention belongs to the field of biology and medical testing, and relates to a tumor biomarker and its clinical application, in particular to a MicroRNA specific expression profile and its application. The MicroRNA specific expression profile is related to early tumor recurrence after liver transplantation of liver cancer Diagnosis is related to prognostic judgment. Background technique

[0002] Since 2004, with the continuous progress in the research of tumor molecular markers, microRNA has become a hot spot in the research of molecular markers. The prior art discloses that MicroRNAs (miRNAs) are single-stranded small RNAs of about 21-23 bases, which are made from a single-stranded RNA precursor with a hairpin structure of about 70-90 bases in size through Dicer enzyme. Produced after processing, different from siRNA (double-stranded) but closely related to siRNA. It is speculated that these small non-coding RNAs (miRNAs) are involved in reg...

Claims

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