Polyethylene glycol-niclosamide composite molluscicide

Abstract

The invention discloses a polyethylene glycol-niclosamide composite molluscicide which is composed of polyethylene glycol, niclosamide and dechlorinated tap water, wherein the weight ratio of polyethylene glycol to niclosamide is (5.67-3):1; the weight of niclosamide is 15-25% of total weight of the composite molluscicide; and polyethylene glycol is polyethylene glycol PEG6000. Due to no organic solvent, the composite molluscicide has the characteristics of little stimulation to operators and more safety in production, storing and transportation processes and the like; and the composite molluscicide is also capable of increasing the effect on killing ampullaria gigas of the niclosamide.

Description

technical field [0001] The invention relates to a preparation method of polyethylene glycol (PEG)-niclosamide complex and its application for killing apple snails. Background technique [0002] Niclosamide (Niclosamide), its chemical name is 4'-2', 5-dichloro salicylanilide (see structure figure 1 ), also known as Beiluokill, Mietailing, and Yumosheng, are high-efficiency, low-toxic drugs for repelling tapeworms for humans and livestock, and have been included in the Chinese Pharmacopoeia, the British Pharmacopoeia, and the European Pharmacopoeia. Niclosamide is a salicylanilide derivative, almost insoluble in water (PH6.4, 1.6mg / L), slightly soluble in ethanol, chloroform, ether, ethyl acetate and pyridine, etc. The drug is characterized by good molluscicidal properties and low impact on the environment, so it is the only molluscicidal drug recommended by the World Health Organization (WHO), and the only molluscicidal drug used on-site in my country. However, because nicl...

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Problems solved by technology

[0003] In 2010, Dai Jianrong et al.’s “Research Progress on the Molluscum-killing Drug Niclosamide” introduced the current research on the improvement of niclosamide dosage forms, such as making wettable powders, powders, and suspensions of niclosamide and its ethanolamine salts. The molluscicidal effect of niclosamide, suspoemulsion, nano preparation, slow-release agent, colloidal suspension, etc. is improved. Although these methods solve the solubility of niclosamide, they still need to add a variety of auxiliary agents in the production process. , if you want to add fillers, wetting agents, carriers, auxiliary agents, viscosity regulators, preservatives, antifreeze, etc., some also need to be added to the sand mill for grinding and stirring, which makes the production process more complicated, and some also need to add a large amount of organic solvents, causing environmental pollution, etc.

At present, only Fan Xiaolin's research group of Jiangxi Gannan Normal University published "Synthesis and Structural Characterization of Niclosamide Derivatives" in 2007 and PEG200 with different molecular weights synthesized by different routes in 2008. , PEG400, and PEG600 are three PEG-niclosamide derivatives, but they all focus on the synthesis and structural characterization of PEG-niclosamide derivatives, but they do not develop these PEG-niclosamide derivatives in the laboratory. Or on-site molluscicide research, and the preparation of PEG and niclosamide compound, molluscicide research and application as pesticides have not been reported

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