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Application of gingerol and cerous oxalate composition to preparation of toxicity-decreasing and efficacy-increasing drugs for cancer chemotherapy

A composition and technology of gingerol, which is applied in the direction of drug combination, digestive system, anti-tumor drugs, etc., can solve the problems of patients with severe vomiting, strong toxic and side effects, and high price, and achieve good anti-emetic and tumor-inhibiting effects

Inactive Publication Date: 2014-04-02
WUHAN KANGLIYUAN MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, intravenous injection of anticancer drug rare metal cisplatin (Pt) can cause severe vomiting in 90% of patients
Frequent vomiting can lead to a large loss of digestive juice, water, electrolyte, acid-base balance disorders, malnutrition, make patients miserable, seriously affect the quality of life of patients, not only affect the curative effect, but even make patients unbearable and interrupt treatment
[0003] At present, antiemetic drugs commonly used in clinic mainly include histamine, acetylcholine, dopamine receptor antagonists and cannabinoids, etc., but these drugs have poor curative effect on post-chemotherapy vomiting, and have strong toxic and side effects, so their application is greatly limited
Newer antiemetics, such as NK 1 Antagonists and 5-HT 3 Receptor antagonist drugs, although effective in antiemetic and antiemetic after chemotherapy, are expensive, have a narrow range of use, and have large toxic and side effects. Clinically, they often need to be used in combination, and there is no anticancer synergistic effect. Therefore, natural anticancer drugs are expected. Development of drugs with attenuated toxicity and enhanced efficacy for cancer

Method used

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  • Application of gingerol and cerous oxalate composition to preparation of toxicity-decreasing and efficacy-increasing drugs for cancer chemotherapy
  • Application of gingerol and cerous oxalate composition to preparation of toxicity-decreasing and efficacy-increasing drugs for cancer chemotherapy
  • Application of gingerol and cerous oxalate composition to preparation of toxicity-decreasing and efficacy-increasing drugs for cancer chemotherapy

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Experimental program
Comparison scheme
Effect test

Embodiment approach

[0019] The first step: preparation of gingerol

[0020] Cut the ginger into thin slices, dry it naturally, grind it into powder with a high-speed universal pulverizer, pass through a 30-mesh sieve, put the sifted fine powder into a 5000mL large grinding bottle, soak it with 6 times the amount of acetone at room temperature for 72 hours; ℃, ultrasonic extraction at 40KHz ultrasonic frequency for 15min; centrifugation to obtain the supernatant, and the residue was discarded; the supernatant was filtered under reduced pressure, and the filtrate was placed in a rotary evaporator for vacuum concentration to obtain a ginger extraction mixture, and then the mixture was Gingerol was obtained by repeated concentration, drying and purification.

[0021] Step 2: preparation of preparation

[0022] (1) Preparation of pharmaceutical composition capsule preparation of the present invention

[0023] Weigh 80 mg of gingerol and 20 mg of cerium oxalate prepared in the above steps, and simult...

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Abstract

Disclosed is application of a gingerol and cerous oxalate composition to preparation of toxicity-decreasing and efficacy-increasing drugs for cancer chemotherapy. The invention relates to a pharmaceutical composition, a preparation method of the pharmaceutical composition, and the application of the pharmaceutical composition to preparation of the toxicity-decreasing and efficacy-increasing drugs for cancer chemotherapy. The natural pharmaceutical composition is composed of gingerol and cerous oxalate according to a ratio of 1-9:1, and has a fine curative effect in vomit caused by cancer chemotherapy and an inhibitory effect in tumor.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, more specifically to a pharmaceutical composition composed of gingerol and cerium oxalate, which is used in the preparation to reduce the side effect of vomiting caused by cancer chemotherapy and has a synergistic effect on the treatment of cancer use in medicines. Background technique [0002] Cancer has become a major killer facing human beings. Although chemotherapy has a certain effect, most patients will experience nausea, vomiting and other gastrointestinal reactions after chemotherapy. For example, intravenous injection of anticancer drug rare metal cisplatin (Pt) can cause severe vomiting in 90% of patients. Frequent vomiting can lead to a large loss of digestive juice, water, electrolyte, acid-base balance disorders, malnutrition, make patients miserable, seriously affect the quality of life of patients, not only affect the curative effect, but even make patients unbearable and in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/194A61K31/12A61P35/00A61P1/08
Inventor 岳川张继国毛晓红刘占涛张景智岳旺
Owner WUHAN KANGLIYUAN MEDICAL SCI & TECH
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