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Extract containing breviscapine and preparation method thereof

A technology of breviscapine and extract, which is applied in the directions of medical preparations, antiviral agents, and drug combinations containing active ingredients to achieve the effects of abundant resources, sufficient supply, and reduced damage

Inactive Publication Date: 2013-07-31
王祥红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But currently there is only a GAP planting base for Erigeron breviscapus in Luxi, Yunnan

Method used

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  • Extract containing breviscapine and preparation method thereof
  • Extract containing breviscapine and preparation method thereof
  • Extract containing breviscapine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044]The preparation method of the extract of the present invention can adopt organic solvent or alkali extraction, and obtain a crude extract containing scutellarin through acid treatment, for example, obtain a crude extract containing more than 10% scutellarin; then large Further purification by pore resin separation technology or propanol treatment provides a relatively high-purity scutellarin-containing extract, for example, an extract with a scutellarin content range greater than 60%. The acid used in the preparation method of the present invention includes but not limited to hydrochloric acid, sulfuric acid, phosphoric acid, carbonic acid or acetic acid, formic acid; the base includes but not limited to sodium hydroxide, potassium hydroxide, ammonium water, arginine, lysine , histidine, sodium carbonate, sodium bicarbonate, sodium hydrogen phosphate.

[0045] Scutellarin contains scutellarin and a small amount of scutellarin. In the present invention, scutellarin is use...

Embodiment 1

[0048] Example 1: Determination of Fingerprint Spectrum and Scutellarin

[0049] Preparation of the test solution: Take this product, crush it through a No. 2 sieve, accurately take about 1.0g, add methanol to reflux and extract twice, 50ml each time, 30min, filter, combine the filtrates, evaporate to dryness in a water bath, add 60% of the residue Dissolve in methanol and dilute to 10ml, shake well, pass through a 0.45μm membrane filter, and obtain.

[0050] Preparation of reference substance solution: Accurately weigh an appropriate amount of scutellarin reference substance dried at 105°C to constant weight, add methanol to make a solution containing 0.2mg per 1ml, and obtain it.

[0051] Instrument: Agilent 1100 (including quaternary gradient pump, autosampler, column thermostat, diode array detector)

[0052] Chromatographic conditions:

[0053] Chromatographic column: Zorbax SB C18 (4.6×250mm, 5μm)

[0054] Mobile phase: A. 0.5% formic acid, B. acetonitrile, C. meth...

Embodiment 2

[0065] Embodiment 2: Determination of the content of scutellarin in the water flying canopy

[0066] The method is the same as in Example 1, and the results are shown in Table 1.

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Abstract

The invention discloses an extract containing breviscapine and a preparation method thereof. The extract is derived from a compositae erigeron or conyza plant. The invention particularly relates to an extract containing breviscapine which is prepared by performing process steps such as solvent extraction, separation, concentration, drying and the like on an erigeron plant, i.e., annual fleabane herb and conyza plants such as horseweed herb, conyza sumatrensis and conyza bonariensis serving as raw materials. The extract can be prepared into a plurality of dosage forms such as injections, tablets, capsules and the like together with pharmaceutically-acceptable auxiliary materials. The annual fleabane herb, horseweed herb, conyza sumatrensis and conyza bonariensis are biological invasive plant varieties. Due to the adoption of the annual fleabane herb, horseweed herb, conyza sumatrensis and conyza bonariensis to preparation of breviscapine, the source is extremely wide, a plurality of medicinal values are achieved, damages of the annual fleabane herb and the like on biological diversity can be reduced, harm is converted into benefit, and multiple things are achieved at one stroke.

Description

technical field [0001] The present invention relates to an extract containing breviscapine, in particular to an extract containing breviscapine prepared from plants of the genus Asteraceae or Liquor, a method for preparing the extract and a preparation prepared by using the extract . Background technique [0002] There are more than 200 species of plants in the genus Asteraceae, mainly including Erigeron breviscapus, Erigeron annuus, Erigeron elongatus Ledeb, Erigeron molle D Don, etc. . Cold in nature, slightly bitter, sweet and warm, has the functions of dispelling cold and relieving exterior syndrome, expelling wind and dampness, promoting blood circulation and removing blood stasis, reducing inflammation and pain, clearing heat and detoxification, resolving phlegm and relieving cough. Clinically, it is mainly used to treat cardiovascular and cerebrovascular diseases and various inflammations. [0003] There are more than 80 kinds of plants in the genus Liquor, mainly ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P9/10A61P13/12A61P3/10A61P11/00A61P9/00A61P1/16A61P31/20
Inventor 王祥红
Owner 王祥红
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