Sulfadoxine composite nanoemulsion antibacterial medicine and preparation method thereof
A technology of sulfadoxine and antibacterial drugs, which is applied in the field of sulfadoxine composite nanoemulsion antibacterial drugs and preparation thereof, can solve the problems of unsatisfactory treatment effect, unsatisfactory absorption, incomplete absorption and the like, and achieves the improvement of bioavailability, Significant antibacterial effect, rapid absorption effect
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[0029] The beneficial effect of the medicament of the present invention will be further elaborated below through the preparation method, product formula and product use effect test given by the inventor.
[0030] Verification test:
[0031] 1.1 Experiments to verify its curative effect:
[0032] Take monensin, sulfadoxine tablets, cinnamaldehyde nanoemulsion and sulfadoxine composite nanoemulsion as controls.
[0033] Determination of the inhibition zone: Use the filter paper method to draw 0.1 mL of each test bacterial suspension in turn, add it to the LB plate medium, and spread it evenly with a sterile glass triangular coating rod. Use a puncher to punch the filter paper into discs with a diameter of 5 mm. After autoclaving, put them into a flat plate that has been coated with bacteria. Add 10% sulfadoxine tablet suspension and 10% cinnamaldehyde unilaterally to each piece. Essential oil nanoemulsion, 10% monensin, 10% sulfadoxine composite nanoemulsion; each experiment...
Embodiment 1
[0049] 1) Weigh 0.01 g, carvacrol 5.8 g, EL-40 35 g 、 Co-surfactant 1 g, distilled water 58.19 g for subsequent use;
[0050] 2) Add sulfadoxine to the oil phase and stir until completely dissolved, set aside;
[0051] 3) Add the oil containing sulfadoxine into the surfactant or the mixture of surfactant and co-surfactant and stir evenly;
[0052] 4) Slowly add distilled water at room temperature, and stir while adding distilled water, until a transparent and clear liquid, colorless or yellow, liquid with low viscosity and good fluidity is formed.
Embodiment 2
[0054] Composed of sulfadoxine 0.8g, cinnamaldehyde 3.9g, EL-40 35.1g, distilled water 60.2g.
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