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Sulfadoxine composite nanoemulsion antibacterial medicine and preparation method thereof

A technology of sulfadoxine and antibacterial drugs, which is applied in the field of sulfadoxine composite nanoemulsion antibacterial drugs and preparation thereof, can solve the problems of unsatisfactory treatment effect, unsatisfactory absorption, incomplete absorption and the like, and achieves the improvement of bioavailability, Significant antibacterial effect, rapid absorption effect

Inactive Publication Date: 2012-09-12
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The particle size of these oral dosage forms is too large, the absorption after oral administration is not ideal, the absorption is incomplete, easy to form accumulation effect in the body, and the therapeutic effect is not ideal

Method used

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  • Sulfadoxine composite nanoemulsion antibacterial medicine and preparation method thereof

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Effect test

preparation example Construction

[0029] The beneficial effect of the medicament of the present invention will be further elaborated below through the preparation method, product formula and product use effect test given by the inventor.

[0030] Verification test:

[0031] 1.1 Experiments to verify its curative effect:

[0032] Take monensin, sulfadoxine tablets, cinnamaldehyde nanoemulsion and sulfadoxine composite nanoemulsion as controls.

[0033] Determination of the inhibition zone: Use the filter paper method to draw 0.1 mL of each test bacterial suspension in turn, add it to the LB plate medium, and spread it evenly with a sterile glass triangular coating rod. Use a puncher to punch the filter paper into discs with a diameter of 5 mm. After autoclaving, put them into a flat plate that has been coated with bacteria. Add 10% sulfadoxine tablet suspension and 10% cinnamaldehyde unilaterally to each piece. Essential oil nanoemulsion, 10% monensin, 10% sulfadoxine composite nanoemulsion; each experiment...

Embodiment 1

[0049] 1) Weigh 0.01 g, carvacrol 5.8 g, EL-40 35 g 、 Co-surfactant 1 g, distilled water 58.19 g for subsequent use;

[0050] 2) Add sulfadoxine to the oil phase and stir until completely dissolved, set aside;

[0051] 3) Add the oil containing sulfadoxine into the surfactant or the mixture of surfactant and co-surfactant and stir evenly;

[0052] 4) Slowly add distilled water at room temperature, and stir while adding distilled water, until a transparent and clear liquid, colorless or yellow, liquid with low viscosity and good fluidity is formed.

Embodiment 2

[0054] Composed of sulfadoxine 0.8g, cinnamaldehyde 3.9g, EL-40 35.1g, distilled water 60.2g.

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Abstract

The invention discloses a sulfadoxine composite nanoemulsion antibacterial medicine. The sulfadoxine composite nanoemulsion antibacterial medicine comprises the following components in percentage by mass: 0.01 to 1.4 percent of sulfadoxine, 3 to 5.8 percent of oil, 28 to 35 percent of surfactant, 0 to 8.4 percent of cosurfactant and the balance of distilled water, wherein the mass percentage sum of the components is 100 percent. The sulfadoxine composite nanoemulsion antibacterial medicine is a clear and transparent liquid, has the characteristics of low viscosity, high stability, high dispersibility, quickness in absorption and the like, can improve the bioavailability of the medicine, prolongs the half-life period of the medicine in vivo, enhancea the curative effect, reduces the toxicity, has sustained release and targeted effects, and has the advantages of low energy consumption during manufacturing, low toxicity, high safety and the like.

Description

technical field [0001] The invention belongs to the field of nano-medicines, relates to a new dosage form of antibacterial drugs, in particular to a sulfadoxine composite nano-emulsion anti-bacterial drug and a preparation method thereof. Background technique [0002] Sulfadoxine is a long-acting sulfonamide drug with broad-spectrum antibacterial effect. It can compete with p-amino acid benzoic acid to act on the dihydrofolate synthase in bacteria, prevent the folic acid needed by bacteria, and inhibit the growth and reproduction of bacteria. It is commonly used for bacterial infections such as hemolytic streptococcus, pneumococcus and Shigella; and combined with pyrimethamine, it is effective against chloroquine-resistant malaria parasites. [0003] Cinnamaldehyde, commonly known as cinnamaldehyde, is a colorless to light yellow oily liquid with a strong cinnamon smell. It occurs naturally in essential oils such as Sri Lankan Cinnamon Oil, Cassia Bark Oil, Patchouli Oil, H...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/505A61K47/44A61K47/26A61P31/04A61K31/11A61K31/05
Inventor 欧阳五庆兰莹赵常宇
Owner NORTHWEST A & F UNIV
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