Application of sea-buckthorn seed oil to preparation of medicament for preventing and/or treating depression

A technology of sea buckthorn seed oil and depression, applied in the application, food preparation, drug combination and other directions, can solve problems such as no literature reports, and achieve the effects of low price, small adverse reactions and obvious efficacy

Inactive Publication Date: 2013-10-30
山西盈科正欣生物科技有限公司
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Seabuckthorn seed oil extracted from seabuckthorn seeds is rich in a variety of biologically active ingredients, including organic acids such as malic acid and oxalic acid, as well as active ingredients such as flavonoids, vitamin C, vitamin E, unsaturated fatty acids, and sterols. Cerebrovascular disease, hypertension, hyperlipidemia, and liver disease have good preventive or therapeutic effects, but the effect of seabuckthorn seed oil on nervous and mental system diseases, especially depression, has not been reported in the literature

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of sea-buckthorn seed oil to preparation of medicament for preventing and/or treating depression
  • Application of sea-buckthorn seed oil to preparation of medicament for preventing and/or treating depression
  • Application of sea-buckthorn seed oil to preparation of medicament for preventing and/or treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Forced swimming test in mice

[0017] 1.1 Experimental equipment and reagents

[0018] Animal behavior video analysis system (Chengdu Taimeng Technology Co., Ltd.), thermometer, timer, plexiglass cylinder, 50mL graduated centrifuge tube (Corning company), animal gastric device (Beijing Jiandel Technology Co., Ltd.). Edible soybean salad oil (Golden Dragon Fish brand), sea buckthorn seed oil (Inner Mongolia Yuhangren High-tech Industry Co., Ltd.), venlafaxine hydrochloride (Chengdu Southwest Pharmaceutical Co., Ltd.).

[0019] 1.2 Experimental animals and administration

[0020] Male ICR mice (Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd., license number: SCXK (京) 2006-0008), 18-22g, after 1 week of adaptive feeding, were randomly divided into 5 groups, each with 12 mice. The dosage of venlafaxine is 0.05g / kg, and the high, medium and low doses of seabuckthorn seed oil are 2.0g / kg, 1.0g / kg and 0.5g / kg. Dilute with salad oil before use (concentration of ...

Embodiment 2

[0032] Example 2 Mouse tail suspension test

[0033] 2.1 Experimental equipment and reagents

[0034] Animal behavior video analysis system (Chengdu Taimeng Technology Co., Ltd.), mouse tail suspension hook, timer, 50mL graduated centrifuge tube (Corning), animal gastric device (Beijing Jiandel Technology Co., Ltd.). Edible soy salad oil (Golden Dragon Fish brand), sea buckthorn seed oil (Inner Mongolia Yuhangren High-tech Industry Co., Ltd.), venlafaxine hydrochloride (Chengdu Southwest Pharmaceutical Co., Ltd.).

[0035] 2.2 Experimental animals and administration

[0036] The experimental animals and the administration were the same as in Example 1.

[0037] 2.3 Experimental method

[0038] 1h after the last administration, stick the mouse tail tip 1cm on the hanging hook, and hang the mouse into the observation box of the animal behavior video analysis system, record the desperate behavior of the mouse within 6min, 4min after analysis The immobile time of the mouse within.

[0039] ...

Embodiment 3

[0044] Example 3 Mouse opening test

[0045] 3.1 Experimental equipment and reagents

[0046] Animal behavior video analysis system (Chengdu Taimeng Technology Co., Ltd.), opening experiment box (homemade), 50mL graduated centrifuge tube (Corning company), animal gastric device (Beijing Jiandel Technology Co., Ltd.). Edible soy salad oil (Golden Dragon Fish brand), sea buckthorn seed oil (Inner Mongolia Yuhangren High-tech Industry Co., Ltd.), venlafaxine hydrochloride (Chengdu Southwest Pharmaceutical Co., Ltd.).

[0047] 3.2 Experimental animals and administration

[0048] The experimental animals and the administration were the same as in Example 1.

[0049] 3.3 Experimental method

[0050] One hour after the last administration, the mice were placed in a 50×50×50cm black open field experiment box (the bottom was divided into 25 grids with white lines evenly), and the animal behavior video analysis system was used to record the autonomy of the mice in the box within 4 minutes The ac...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides new application of sea-buckthorn seed oil extracted from sea-buckthorn seeds, i.e., application of the sea-buckthorn seed oil to preparation of a medicament or a health-care food for preventing and / or treating depression, and application of the sea-buckthorn seed oil serving as a raw material to preparation of the medicament or the health-care food for preventing and / or treating the depression. Test results prove that the immobility time in forced swimming tests of mice and tail suspension tests of the mice can be obviously reduced by the sea-buckthorn seed oil and the sea-buckthorn seed oil has an obvious depression suppression effect. The sea-buckthorn seed oil is a natural anti-depression effective substance which has the advantages of easiness and convenience in preparation, obvious effect, safety, reliability and easiness for industrial production. The sea-buckthorn seed oil can be prepared into formulations such as soft capsules, dropping pills and emulsion for anti-depression medicaments or health care foods.

Description

Technical field [0001] The invention relates to a new use of sea buckthorn seed oil, specifically the application of sea buckthorn seed oil in medicines or health foods for the prevention and / or treatment of depression. Background technique [0002] Depression is a common affective mental illness, which is mainly manifested as a significant and lasting depression. Patients with mild depression show poor mood and lack of interest. In severe cases, they show pessimism and despair. They are worried all day long and live like years. , Often suicidal. Depression has the characteristics of high incidence, high recurrence rate and high disability rate. The World Health Organization has listed it as one of the top ten serious diseases. With the rapid development of society and economy, the pace of life has accelerated, people's pressure has increased, and various emotional shocks have increased, causing the incidence of depression to increase year by year. According to WHO's prediction...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P25/24A23L1/29A61K131/00A23L33/00
Inventor 田俊生张丽增郭晓擎史碧云秦雪梅
Owner 山西盈科正欣生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap