Alga bromosesquiterpene compound, preparation thereof and application thereof

A technology of sesquiterpenoids and compounds, applied in seaweed brominated sesquiterpenoids and its preparation and application fields, can solve problems such as ecological imbalance and environmental pollution

Active Publication Date: 2012-09-12
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emergence of chemical pesticides has greatly improved the level of prevention and control of agricultural diseases and insect pests, but a series of problems such as environmental pollution and ecological imbalance caused by long-term use have become increasingly apparent

Method used

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  • Alga bromosesquiterpene compound, preparation thereof and application thereof
  • Alga bromosesquiterpene compound, preparation thereof and application thereof
  • Alga bromosesquiterpene compound, preparation thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Seaweed brominated sesquiterpenoids are shown in formula (I).

[0020]

Embodiment 2

[0022] The preparation method of the seaweed sesquiterpenes shown in formula (I):

[0023] The marine red alga Laurencia composita was dried and crushed, then extracted with chloroform-methanol (volume ratio 1:1), the combined extracts were concentrated to obtain a crude extract; the crude extract was extracted with ethyl acetate Three times and concentrated under reduced pressure to obtain 21.0 g of crude extract after extraction.

[0024] The crude extract was subjected to 100-200 mesh silica gel column chromatography with petroleum ether-ethyl acetate at 100:0, 50:1, 20:1, 10:1, 5:1, 2:1 to 0:100 Gradient elution was carried out, the eluent was collected respectively, and then detected by thin layer chromatography (TLC) (anisaldehyde-sulfuric acid color development), judged according to the Rf value, merged the same or similar parts, and obtained 14 components (1- 14). Fraction 12, which was eluted with petroleum ether-ethyl acetate 10:1 gradient, was separated by gel col...

Embodiment 3

[0029] The difference from Example 2 is that

[0030] Dry and pulverize the marine red algae Pachypsis renaissance, then extract with ethanol, combine the extracts and concentrate to obtain a crude extract; extract the crude extract three times with ethyl acetate and concentrate under reduced pressure to obtain a crude extract after extraction 20.0 g.

[0031] The crude extract was subjected to 100-200 mesh silica gel column chromatography with petroleum ether-acetone at a gradient of 100:0, 60:1, 20:1, 10:1, 5:1, 2:1 to 0:100 Elution, collect the eluate separately, and then detect with thin layer chromatography (TLC) (anisaldehyde-sulfuric acid color development), judge according to the Rf value, combine the same or similar parts, and obtain 14 components (1-14) . Component 12, namely the component eluted with petroleum ether-acetone 10:1 gradient, was separated by gel column, high performance liquid phase and thin layer chromatography. During gel column chromatography, th...

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PUM

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Abstract

The invention relates to fields of insecticides and fungal inhibitors, and concretely relates to an alga bromosesquiterpene compound, a preparation thereof and an application thereof. The concrete structural formula of the compound is represented by formula (I). The preparation method of the compound comprises the following steps: drying and crushing red alga Laurencia composita, and extracting with an organic solvent to obtain crude extracts; and carrying out silica gel column chromatography on the crude extracts, carrying out gradient elution, and separating and purifying components obtained through gradient elution with an eluent volume ratio of 15-10:1 to obtain the target compound (I). Results of insecticidal activity experiments of the bromosesquiterpene compound obtained in the invention show that the lethality of 100mug / ml of the compound to artemia is 87.7%, the median lethal concentration is 37.0mug / ml, and the compound simultaneously has a good antifungal activity.

Description

technical field [0001] The invention relates to the field of insecticides and fungal inhibitors, in particular to a seaweed brominated sesquiterpene compound and its preparation and application. Background technique [0002] my country is a large agricultural country. During the production of food, vegetables and other crops, we often encounter the threat of pests and diseases, resulting in a large area of ​​production reduction. The emergence of chemical pesticides has greatly improved the level of prevention and control of agricultural diseases and insect pests, but a series of problems such as environmental pollution and ecological imbalance caused by long-term use have become increasingly apparent. With the improvement of people's attention to environmental quality and food safety, the demand for developing new types of pollution-free bio-sourced pesticides is gradually increasing. Contents of the invention [0003] The object of the present invention is to provide a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C35/52C07C29/76A01P7/00A01P3/00
Inventor 季乃云李晓栋苗凤萍
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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