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Chinese medicament for treating chronic catarrhal otitis media and preparation method

A technology for catarrhal and otitis media, which is applied in the field of traditional Chinese medicine for the treatment of chronic catarrhal otitis media. It can solve problems such as intractable effusion, poor eustachian tube function, and difficulty in treatment, and achieves the effect of taking it conveniently.

Inactive Publication Date: 2012-09-19
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Cataract otitis media can be easily cured in the acute stage, but after the acute stage, the inflammation often persists, the effusion is difficult to eliminate, and tissue hyperplasia, so chronic catarrhal otitis media is more difficult to treat than acute catarrhal otitis media
[0005] Western medicine mostly uses systemic antibiotics, glucocorticoids, antihistamines, topical nasal drops of mucosal vasoconstrictors, puncture of the tympanic membrane and catheterization in the treatment of chronic catarrhal otitis media, which have certain curative effects, but are not ideal.
Long-term use of antibiotics and glucocorticoids has certain adverse reactions, and tympanic membrane placement can cause chronic suppurative otitis media, secondary cholesteatoma, permanent tympanic membrane perforation, tympanic sclerosis and other complications, and cannot fundamentally solve the eustachian Problems with poor tube function

Method used

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Examples

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Effect test

preparation example Construction

[0062] The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine, when the dosage form of the traditional Chinese medicine is a decoction, it includes the following steps,

[0063] In the first step, the components are mixed in proportion and pulverized into powder;

[0064] In the second step, the powder obtained in the first step is added to cold water and soaked for 6 hours to 12 hours, decocted with a slow fire for 3 hours to 5 hours, and the decoction is filtered to obtain the first filtrate. The quality of the powder is 2 to 4 times that of the powder obtained in the first step;

[0065] In the third step, add the filter residue obtained by the second step of filtration into cold water again, decoct with a slow fire for 2 hours to 4 hours, and filter to obtain the second filtrate. 4 times;

[0066] In the fourth step, the two filtrates are combined to obtain the decoction.

[0067] The present invention also provides ...

Embodiment 1

[0080] The accumulation toxicity test of embodiment 1 Chinese medicine of the present invention

[0081] Experimental drug:

[0082] Coptidis 110g, fenugreek 20g, genus 30g, Zhizhizi 20g, jiubing 40g, Poria cocos 20g, dandelion 60g, mistletoe 30g, summer no 30g, licorice 40g, Codonopsis 30g, gardenia 50g, yam 30g, Mix 30g of reed rhizome, 20g of sumac, 20g of sapphire, 30g of wild chrysanthemum, 20g of aconite and 30g of Dendrobium, crush them into powder, soak the obtained powder in 2000g of cold water for 12 hours, and decoct with slow fire for 5 hours , the decoction was filtered to obtain the first filtrate; the filtered residue was added to 400g of cold water again, decocted with a slow fire for 4 hours, filtered to obtain the second filtrate, and the two filtrates were combined to obtain the decoction.

[0083] experiment method:

[0084]Select 132 female SD rats for use, SPF grade, body weight 80~100g, provided by Guangdong Medical Experimental Animal Center, be divid...

Embodiment 2

[0085] The Chinese medicine tablet that embodiment 2 present invention prepares

[0086] Coptidis 105g, fenugreek 15g, genus vine 25g, zizhizi 15g, jiubing 35g, tuckahoe 15g, dandelion 55g, mistletoe 25g, summer 25g, licorice 35g, Codonopsis 25g, gardenia 45g, yam 25g, Mix 25g of reed root, 15g of sumac, 15g of sapphire, 25g of wild chrysanthemum, 15g of aconite, 25g of dendrobium, 7g of peach kernel, and 7g of safflower, and grind it into powder. Add the obtained powder to 1800g of cold water and soak for 9 hours, and decoct it over low heat , the decoction time is 5 hours, the decoction is filtered to obtain the first filtrate, the filter residue obtained by filtration is added to 200g cold water again, decocted with a slow fire for 4 hours, the second filtrate is obtained by filtration, the first filtrate obtained and The second filtrate obtained in the third step is mixed, concentrated under reduced pressure to remove water, dried, put into a pulverizer and pulverized into...

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Abstract

The invention provides a Chinese medicament for treating chronic catarrhal otitis media. The Chinese medicament comprises coptis, fenugreek, Chinese starjasmine stem, akebia fruit, holly bark, Tuckahoe, dandelion, mistletoe, corydalis decumbentis, licorice, codonopsis pilosula, gardenia, Chinese yam, reed rhizome, sappan wood, smartweed, wild chrysanthemum, monkshood and dendrobe. The novel Chinese medicament for treating the chronic catarrhal otitis media can effectively prevent the disease from being changed into adhesive otitis media, is convenient to take, and can avoid side effects and sequela due to long-term use of antibiotics and hormones, tympanic cavity tubing and the like.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical engineering, in particular to a traditional Chinese medicine for treating chronic catarrhal otitis media. Background technique [0002] Cataract otitis media, also known as non-suppurative otitis media, effusion otitis media, secretory otitis media, serous otitis media, and glue ear, is a common and frequently-occurring disease in clinical otolaryngology. It is reported that the domestic adult incidence rate is 2.16%, and that of children is 2.15%. Generally, the middle ear exudate is serous, thin, and watery in the early stage of the disease course; in the longer course of the disease, it is mostly mucus, thick, turbid, or even jelly-like; if it persists for a long time, some patients may develop into terminal stage Lesion-adhesive otitis media will cause long-term hearing loss, tinnitus, etc. It is difficult to treat, especially for children who cannot cooperate with the treatment or eve...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P27/16
Inventor 李永团迟晓艳
Owner QINGDAO MUNICIPAL HOSPITAL
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